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Phio Pharmaceuticals Announces Participation in the Renmark Financial Communications Live Virtual Non-Deal Roadshow Series

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Phio Pharmaceuticals (NASDAQ: PHIO) will participate in Renmark Financial Communications’ Live Virtual Non-Deal Roadshow Series on Thursday, May 28, 2026 at 12 PM EDT. CEO and Chairman Robert Bitterman will present the company’s INTASYL siRNA gene silencing platform and lead candidate PH-762 for cutaneous carcinomas, followed by a live Q&A.

PH-762, which silences the PD-1 gene, is in a Phase 1b trial (NCT# 06014086) for cutaneous squamous cell carcinoma, melanoma and Merkel cell carcinoma as a potential non-surgical skin cancer treatment.

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AI-generated analysis. Not financial advice.

Positive

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Negative

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News Market Reaction – PHIO

-0.92%
1 alert
-0.92% News Effect

On the day this news was published, PHIO declined 0.92%, reflecting a mild negative market reaction.

Data tracked by StockTitan Argus on the day of publication.

Key Figures

Roadshow date/time: May 28, 2026, 12 PM EDT Trial phase: Phase 1b Clinical trial ID: NCT# 06014086
3 metrics
Roadshow date/time May 28, 2026, 12 PM EDT Renmark Virtual Non-Deal Roadshow presentation and Q&A
Trial phase Phase 1b PH-762 trial in cutaneous squamous cell carcinoma, melanoma, Merkel cell carcinoma
Clinical trial ID NCT# 06014086 Identifier for Phase 1b PH-762 skin cancer trial

Market Reality Check

Price: $1.0800 Vol: Volume 115,858 is close t...
normal vol
$1.0800 Last Close
Volume Volume 115,858 is close to the 20-day average of 134,784 (relative volume 0.86). normal
Technical Shares at $1.09 are trading below the 200-day MA of $1.49 and 73.99% under the 52-week high.

Peers on Argus

PHIO was flat on the day while momentum names like PHGE showed strong upside mov...
2 Up

PHIO was flat on the day while momentum names like PHGE showed strong upside moves, indicating this investor-relations event was stock-specific rather than part of a broad biotech move.

Historical Context

5 past events · Latest: May 12 (Positive)
Pattern 5 events
Date Event Sentiment Move Catalyst
May 12 Fireside chat announced Positive +1.9% Virtual Force Family Office chat on PH-762 data and skin cancer innovations.
May 07 Q1 2026 earnings Neutral -6.1% Q1 results with higher R&D, wider net loss, and PH-762 progress update.
Apr 23 Renmark roadshow Positive -1.6% April Renmark virtual roadshow on INTASYL platform and PH-762 progress.
Apr 13 Fireside chat Positive +2.5% ‘Nobel Prize Winning Science’ virtual chat highlighting Phase 1b PH-762 data.
Apr 09 Conference presentation Neutral -3.9% Centri Capital Conference talk on INTASYL and PH-762 immuno-oncology program.
Pattern Detected

Recent IR- and event-focused news often had mixed or negative price reactions despite generally positive clinical messaging on PH-762.

Recent Company History

Over the past few months, PHIO has repeatedly highlighted its INTASYL siRNA platform and lead candidate PH-762, including fireside chats on April 15 and May 19, 2026, multiple conference and roadshow appearances, and completion of a Phase 1b trial with favorable safety and pathology signals. Q1 2026 results on May 7, 2026 showed higher R&D spend and a wider net loss. Today’s non-deal roadshow notice continues this pattern of outreach centered on PH-762 and its Phase 1b program in skin cancers.

Regulatory & Risk Context

Active S-3 Shelf · $24.5 million
Shelf Active
Active S-3 Shelf Registration 2025-11-20
$24.5 million registered capacity

An effective S-3 shelf filed on 2025-11-20 registers up to 11,763,800 warrant shares for resale by existing holders. Phio would only receive cash upon warrant exercise, with potential proceeds of about $24.5 million earmarked for working capital and PH-762 development. The company is not selling primary shares under this resale prospectus.

Market Pulse Summary

This announcement highlights another investor-relations touchpoint focused on Phio’s INTASYL siRNA p...
Analysis

This announcement highlights another investor-relations touchpoint focused on Phio’s INTASYL siRNA platform and lead candidate PH-762, now in a Phase 1b trial (NCT# 06014086) across several skin cancers. It follows a series of fireside chats, conference talks, and financial updates in 2026 centered on the same program. Investors may watch for forthcoming FDA interactions, later-stage trial design decisions, and any balance sheet or capital-raising moves disclosed in future filings.

Key Terms

sirna, gene silencing, immuno-oncology, phase 1b, +4 more
8 terms
sirna medical
"Phio Pharmaceuticals Corp. ... is a clinical-stage siRNA biopharmaceutical company"
Small interfering RNA (siRNA) is a short strand of genetic material that binds to and destroys the messenger RNA that carries instructions for making a specific protein, effectively switching that gene off. Investors care because siRNA is a platform for precise medicines: successful trials or approvals can create high-value drugs, while delivery challenges, manufacturing complexity, patent positions and regulatory risk can sharply affect a biotech company's prospects.
gene silencing medical
"using its proprietary INTASYL gene silencing technology to eliminate cancer"
Gene silencing is a biological process that turns down or shuts off the activity of a specific gene so it stops making its product, like dimming or muting a single light in a room instead of cutting power to the whole house. Investors care because therapies or products that intentionally silence harmful genes can become new drugs, diagnostics, or royalties, affecting a company’s future revenue, risk profile, and valuation.
immuno-oncology medical
"INTASYL represents a differentiated and promising approach in immuno-oncology"
Immuno-oncology is a field of medicine focused on using the body's immune system to fight cancer. It involves developing treatments that help the immune system recognize and attack cancer cells more effectively. For investors, advancements in immuno-oncology can signal promising new therapies that may lead to improved patient outcomes and potentially significant commercial opportunities.
phase 1b medical
"The Phase 1b trial (NCT# 06014086) is evaluating PH-762"
"Phase 1b" is an early stage in testing a new medical treatment or vaccine, where it is given to a small group of people to evaluate its safety and determine the right dose. For investors, this phase signals progress in development, indicating the treatment is advancing through initial safety checks, which can influence expectations for future success and potential market impact.
cutaneous squamous cell carcinoma medical
"evaluating PH-762 for the treatment of cutaneous squamous cell carcinoma, melanoma"
A common form of skin cancer that starts in the thin, outer layer of the skin and can grow or, in some cases, spread to nearby tissue or organs. For investors, it matters because diagnosis rates, available treatments, and regulatory approvals shape demand for therapies, influence clinical trial results, and affect potential revenue for companies developing drugs, devices, or diagnostics — like spotting a stubborn weed that may require different tools to remove.
merkel cell carcinoma medical
"melanoma and Merkel cell carcinoma. PH-762 is a potential non-surgical treatment"
Merkel cell carcinoma is a rare, fast-growing form of skin cancer that starts in cells near the base of the skin and often spreads quickly to nearby tissues and organs. For investors, it matters because treatments for this aggressive disease can create high-value opportunities or risks: successful drugs or tests can unlock significant revenue and partnerships, while failed trials or regulatory setbacks can sharply affect a biotech company’s prospects — like a single critical test determining whether a new product succeeds or stalls.
pd-1 medical
"PH-762, that silences the PD-1 gene implicated in various forms of skin cancer"
PD-1 is a protein found on certain immune cells that acts like a brake, signaling the immune system to slow down and avoid damaging healthy tissue. Drugs that block PD-1 release that brake so immune cells can better attack cancer cells; because such therapies can produce large clinical benefits, regulatory approvals, trial outcomes, pricing and market uptake for PD-1 drugs can materially affect a drugmaker’s prospects and investor returns.
nct# 06014086 medical
"The Phase 1b trial (NCT# 06014086) is evaluating PH-762"
NCT# 06014086 is a unique registry number assigned to a specific clinical trial on ClinicalTrials.gov, the U.S. database that tracks medical studies. Think of it like a tracking number or license plate for a trial: it lets investors and analysts find the trial’s details—purpose, design, enrollment, status and reported results—which matter because those facts show how far a drug or treatment is from approval and how much commercial or regulatory risk remains.

AI-generated analysis. Not financial advice.

Live Presentation and Q&A: Thursday, May 28, 2026 12 PM EDT

King of Prussia, Pennsylvania--(Newsfile Corp. - May 26, 2026) - Phio Pharmaceuticals Corp. (NASDAQ: PHIO) is a clinical-stage siRNA biopharmaceutical company developing therapeutics using its proprietary INTASYL® gene silencing technology to eliminate cancer. Phio Pharmaceuticals announced today that Robert Bitterman, CEO and Chairman of the Board, will present an overview of the Company's INTASYL® siRNA platform, including its lead clinical candidate PH-762 for the treatment of cutaneous carcinomas. The presentation will be followed by a live Q&A session.

"We look forward to participating in the Renmark Virtual Non-Deal Roadshow, where we will discuss why we believe INTASYL represents a differentiated and promising approach in immuno-oncology," said Robert Bitterman, CEO and Chairman of Phio Pharmaceuticals.

Phio's presentation and live Q&A will take place on Thursday May 28, 2026, at 12 PM EDT in the live Virtual Non-Deal Roadshow Series hosted by Renmark Financial Communications Inc.

REGISTER HERE: Renmark Virtual Non-Deal Roadshow NASDAQ - PHIO | Event Registration | Renmark Financial Communications

Please Note: If the link does not work, please copy and paste into your browser. To ensure smooth connectivity, please access the link above using the latest version of Google Chrome.

A replay of the event may be accessed on the Renmark Financial Communications Inc. website at https://www.renmarkfinancial.com/vndrs.

Phio Pharmaceuticals Corp. (NASDAQ: PHIO) is a clinical-stage biopharmaceutical company advancing its proprietary INTASYL® siRNA gene silencing technology to eliminate cancer. Phio's INTASYL compounds are designed to enhance the body's immune cells to more effectively kill cancer cells. Phio's lead clinical development program is an INTASYL compound, PH-762, that silences the PD-1 gene implicated in various forms of skin cancer. The Phase 1b trial (NCT# 06014086) is evaluating PH-762 for the treatment of cutaneous squamous cell carcinoma, melanoma and Merkel cell carcinoma. PH-762 is a potential non-surgical treatment for skin cancers.

For additional information, visit the Company's website, www.phiopharma.com.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as "intends," "believes," "anticipates," "indicates," "plans," "expects," "suggests," "may," "would," "should," "potential," "designed to," "will," "ongoing," "estimate," "forecast," "target," "predict," "could" and similar references, although not all forward-looking statements contain these words. These statements, which include statements, among other things, regarding the anticipated benefits of our INTASYL™ RNAi platform, the results from our ongoing clinical trials, our expectations that our cash runway will extend into the first half of 2027, our expectations regarding timing of FDA submissions intended to propose and seek guidance for next steps in clinical study design for PH-762, our expectations that such FDA submissions and any related FDA meetings will clarify next steps in advancing the PH-762 development program, details regarding our planned non-clinical toxicology study, and our ability to support ongoing clinical development, operational requirements and strategic initiatives with the capital we currently have on hand, are based only on our current beliefs, expectations and assumptions and are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results may differ materially from those indicated in the forward-looking statements as a result of a number of important factors, including, but not limited to, the impact of future FDA interactions on the development of our product candidates; the impact to our business and operations by inflationary pressures; recession fears; the development of our product candidates, results from our nonclinical, preclinical and clinical activities, our ability to execute on business strategies, our ability to develop our product candidates with collaboration partners, and the success of any such collaborations, the timeline and duration for advancing our product candidates into clinical development, the timing or likelihood of regulatory filings and approvals, the success of our efforts to commercialize our product candidates if approved, our ability to manufacture and supply our product candidates for clinical activities, and for commercial use if approved, the scope of protection we are able to establish and maintain for intellectual property rights covering our technology platform, our ability to obtain future financing, market and other conditions and those risks identified in our most recent Annual Report on Form 10-K and subsequent Quarterly Reports on Form 10-Q under the caption "Risk Factors" and in other filings the Company periodically makes with the U.S. Securities and Exchange Commission. Readers are urged to review these risk factors and to not act in reliance on any forward-looking statements, as actual results may differ from those contemplated by our forward-looking statements. Phio does not undertake to update forward-looking statements to reflect a change in its views, events or circumstances that occur after the date of this release, except as required by law.

Contact:
Phio Pharmaceuticals Corp.
Jennifer Phillips: jphillips@phiopharma.com
Corporate Affairs

Renmark Financial Communications Inc.
James R. Kautz: jkautz@renmarkfinancial.com
Tel: (416)-644-2020 or (212)-812-7680
www.renmarkfinancial.com

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/298745

FAQ

When is Phio Pharmaceuticals (NASDAQ: PHIO) presenting at the Renmark Virtual Non-Deal Roadshow in May 2026?

Phio Pharmaceuticals presents on Thursday, May 28, 2026, at 12 PM EDT. According to Phio, the session includes an overview of its INTASYL siRNA platform, details on lead candidate PH-762, and a live investor Q&A.

How can investors register for the Phio Pharmaceuticals (PHIO) Renmark Virtual Non-Deal Roadshow?

Investors can register through the Renmark Virtual Non-Deal Roadshow event page for NASDAQ: PHIO. According to Phio, attendees should use the latest version of Google Chrome and may access a replay later on Renmark’s website.

Will there be a replay of the Phio Pharmaceuticals (PHIO) Renmark virtual roadshow event?

Yes, a replay may be accessed on Renmark Financial Communications’ website. According to Phio, investors who cannot attend the May 28, 2026 live event can later view the presentation and Q&A through Renmark’s vNDRS platform.

What is Phio Pharmaceuticals’ INTASYL siRNA gene silencing technology for cancer?

INTASYL is Phio’s proprietary siRNA gene silencing platform aimed at eliminating cancer. According to Phio, INTASYL compounds are designed to enhance the body’s immune cells so they can more effectively kill cancer cells in various tumor settings.

What is Phio Pharmaceuticals’ lead candidate PH-762 and what cancers is it targeting?

PH-762 is an INTASYL compound that silences the PD-1 gene linked to skin cancers. According to Phio, a Phase 1b trial (NCT# 06014086) evaluates PH-762 in cutaneous squamous cell carcinoma, melanoma and Merkel cell carcinoma as a potential non-surgical option.

What stage is the PH-762 clinical trial and what is its primary focus for PHIO?

PH-762 is in a Phase 1b clinical trial targeting several cutaneous carcinomas. According to Phio, the study assesses PH-762 in cutaneous squamous cell carcinoma, melanoma and Merkel cell carcinoma as a potential non-surgical treatment for skin cancers.