Praxis Precision Medicines, Inc. Stock Price, News & Analysis

Praxis Precision Medicines (NASDAQ: PRAX), a clinical-stage biopharmaceutical company focused on developing CNS disorder therapies, has announced its participation in five major investor conferences in March 2025:

• 45th Annual TD Cowen Health Care Conference in Boston (March 5, 9:10 AM EDT)
• Leerink Partners Global Healthcare Conference in Miami (March 10, 3:40 PM EDT)
• Jefferies Biotech on the Bay Summit in Miami (March 11)
• Barclays 27th Annual Global Healthcare Conference in Miami (March 12, 2:30 PM EDT)
• UBS Virtual CNS Day (March 17, 9:30 AM EDT)

The company will present corporate overviews, participate in fireside chats, and offer one-on-one investor meetings. Live webcasts will be available for most events, with 90-day replay access through the company's website.

Praxis Precision Medicines (NASDAQ: PRAX) announced that the Independent Data Monitoring Committee (IDMC) recommended stopping Study 1 of the Essential3 program for futility, as it's unlikely to meet primary efficacy endpoints. Despite this, Praxis will continue both Study 1 and 2 to completion, with topline results expected in Q3 2025.

The company provided updates on multiple pipeline programs including:

• Vormatrigine trials RADIANT and POWER1 for focal onset seizures with results expected in 2025
• Relutrigine development for epilepsies with EMERALD study initiation by mid-2025
• Elsunersen EMBRAVE3 trial for SCN2A-DEE starting mid-2025

Financial highlights show $469.5 million in cash and equivalents as of December 31, 2024, expected to fund operations into 2028. Q4 2024 net loss was $58.7 million, with full-year 2024 net loss at $182.8 million.

Praxis Precision Medicines (Nasdaq: PRAX) has announced new equity grants under its 2024 Inducement Plan. The company's Compensation Committee approved stock options to purchase 4,050 shares and restricted stock unit awards covering 3,038 shares for three new non-executive employees on February 3, 2025.

The stock options were granted at an exercise price of $80.26 per share, matching the closing price of Praxis' common stock on the grant date. The options will vest over four years, with 25% vesting after the first year and the remainder vesting monthly over three years. The restricted stock units will vest in four equal annual installments. These grants were made as employment inducements in accordance with Nasdaq Listing Rule 5635(c)(4).

Praxis Precision Medicines (NASDAQ: PRAX), a clinical-stage biopharmaceutical company focused on developing CNS disorder therapies, has announced its participation in two upcoming investor conferences in February 2025.

The company will participate in a fireside chat at the Guggenheim Securities SMID Cap Biotechnology Conference in New York City on February 6, 2025, at 2:30 p.m. EST, and at the Oppenheimer 35th Annual Healthcare Life Sciences Conference, taking place virtually on February 11, 2025, at 11:20 a.m. EST.

One-on-one meetings with investors will be available during both conferences through respective representatives. Live webcasts will be accessible through provided links and the company's website, with replays available for 90 days under the 'Events and Presentations' page in the 'Investors + Media' section.

Praxis Precision Medicines (NASDAQ: PRAX) outlined its 2025 corporate strategy, highlighting three late-stage clinical trials with blockbuster potential and four pivotal readouts expected in 2025. The company anticipates four commercial assets by 2028.

Key developments include: Study 1 of Essential3 program for ulixacaltamide in essential tremor with Q1 2025 interim analysis; EMBOLD study of relutrigine progressing towards 2026 NDA filing; vormatrigine ENERGY program advancing with RADIANT and POWER1 readouts in 2025. UCB has exercised its option to license the KCNT1 small molecule candidate.

The company reports approximately $470 million in cash and investments at the end of 2024, supporting operations into 2028. Multiple clinical programs are advancing, including treatments for essential tremor, epilepsies, and developmental and epileptic encephalopathies (DEEs).

Praxis Precision Medicines (NASDAQ: PRAX) has announced its participation in the 43rd Annual J.P. Morgan Healthcare Conference. The company, which focuses on developing therapies for central nervous system (CNS) disorders, will present a corporate overview at the conference on January 15, 2025, at 2:15pm PST at the Westin St. Francis Hotel in San Francisco.

The presentation will be accessible through a live webcast, and a replay will remain available for 30 days through the company's website at www.praxismedicines.com in the Investors + Media section under 'Upcoming & Recent Events'.

Praxis Precision Medicines (NASDAQ: PRAX) has received Rare Pediatric Disease Designation (RPDD) from the FDA for relutrigine in treating Dravet syndrome, a genetic developmental and epileptic encephalopathy. This marks the third RPDD for relutrigine, following previous designations for SCN2A and SCN8A DEEs.

The company plans to initiate an all-DEE trial (EMERALD) in 1H2025. Recent clinical results from the EMBOLD study showed promising outcomes, including a 46% placebo-adjusted monthly motor seizure reduction, over 30% of patients achieving seizure freedom, and a 77% reduction in median seizure rate during long-term extension. Praxis is currently enrolling patients in a second, registrational cohort for SCN2A and SCN8A patients, with topline results expected in 1H2026.

Praxis Precision Medicines (NASDAQ: PRAX) has announced its participation in two major investor conferences in December 2024. The company will present at the Piper Sandler 36th Annual Healthcare Conference in New York on December 4, featuring a fireside chat at 2:00pm ET. Additionally, Praxis will participate in the Oppenheimer Movers in Rare Disease Summit on December 12, where management will join a panel discussing rare disease companies with near-term catalysts.

Both events will take place in New York, with one-on-one meeting opportunities available for interested investors. A live webcast of the Piper Sandler presentation will be accessible through the company's website, with a replay available for 90 days afterward.

Praxis Precision Medicines (NASDAQ: PRAX) announced its participation in the 2024 American Epilepsy Society Annual Meeting, where it will present data from three epilepsy programs. The company will showcase updates through five poster presentations featuring their clinical-stage assets, including relutrigine and vormatrigine, described as the most potent and selective anti-seizure medications developed to date. The presentations will focus on preclinical and clinical data, including results from the EMBOLD study in childhood epilepsies. The event will be held from December 6-10, 2024, in Los Angeles, with Praxis exhibiting at booth #1235 and hosting a scientific exhibit.