Prime Medicine Stock Price, News & Analysis

Prime Medicine (PRME) announced a strategic restructuring and leadership transition. Allan Reine, M.D., the company's CFO, will succeed Keith Gottesdiener as CEO, while Jeff Marrazzo becomes Executive Chair. The company is implementing significant changes, including: • Deprioritizing Chronic Granulomatous Disease programs • Focusing on Wilson's Disease and Alpha-1 Antitrypsin Deficiency (AATD) liver programs • Reducing workforce by ~25% • Continuing Cystic Fibrosis program with CF Foundation support • Maintaining partnership with Bristol Myers Squibb for CAR-T products The company plans to file IND/CTA for Wilson's Disease in 1H 2026 and AATD in mid-2026, with initial clinical data expected in 2027. The restructuring aims to cut operating expenses and cash burn by almost half through 2027. Current cash runway extends into 1H 2026.

Prime Medicine (NASDAQ: PRME) has announced groundbreaking clinical data from its first patient treated with PM359, a Prime Editor therapy for Chronic Granulomatous Disease (CGD). The Phase 1/2 trial showed that a single infusion of PM359 restored NADPH oxidase activity to 58% by Day 15 and 66% by Day 30, significantly exceeding the 20% threshold for clinical benefit. The therapy demonstrated rapid engraftment in neutrophils (Day 14) and platelets (Day 19), nearly twice as fast as existing gene editing technologies. The treatment was well-tolerated with no serious adverse events related to PM359. Despite these promising results, Prime Medicine plans to seek external partners for PM359's continued development while focusing its resources on advancing its in vivo liver franchise, including programs for Wilson's Disease and Alpha-1 Antitrypsin Deficiency, as well as its Cystic Fibrosis program and CAR-T development partnership with Bristol Myers Squibb.

Prime Medicine (PRME) reported Q1 2025 financial results and provided pipeline updates. The company's net loss widened to $51.9M from $45.8M year-over-year, with cash position at $158.3M. Key pipeline developments include expected initial data from Phase 1/2 trial of PM359 for p47phox CGD in 2025, advancement of PM577 for Wilson's Disease with IND/CTA filing planned for 1H 2026, and unveiling of a new AATD program targeting mid-2026 for IND/CTA filing. R&D expenses increased to $40.6M from $37.8M, while G&A expenses rose to $13.3M from $11.2M. The company expects current cash runway to extend into first half of 2026. Prime Medicine's pipeline focuses on developing Prime Editors across hematology, immunology, oncology, liver, and lung diseases, including partnerships with Bristol Myers Squibb for T-cell therapies.

Prime Medicine (Nasdaq: PRME) has unveiled a preclinical program for treating alpha-1 antitrypsin deficiency (AATD), marking their second liver franchise program. The company plans to file an IND/CTA in mid-2026.

The program utilizes Prime's proprietary universal liver lipid nanoparticle (LNP) to edit the E342K (Pi*Z) mutation in the SERPINA1 gene. Initial in vivo data showed up to 72% precise correction of the SERPINA1 gene in hepatocytes of humanized mice, restoring over 95% of serum AAT to the corrected isoform with healthy AAT protein levels above 20µM.

Preclinical studies using unoptimized surrogate Prime Editors in non-human primate models demonstrated greater than 50% editing with an excellent safety profile and no detectable off-target edits. The company expects to advance both AATD and Wilson's Disease programs toward clinical data in 2027.

Prime Medicine (NASDAQ: PRME) has reported its full year 2024 financial results and provided key business updates. The company is progressing with its Phase 1/2 clinical trial of PM359 for p47phox CGD, with initial data expected in 2025. Their Wilson's Disease program (PM577) is advancing through IND-enabling studies, targeting IND/CTA filing in 1H 2026.

Financial highlights for 2024 include:

• R&D expenses increased to $155.3 million (from $147.9M in 2023)
• G&A expenses rose to $50.2 million (from $43.4M in 2023)
• Net loss was $195.9 million (improved from $198.1M in 2023)
• Cash position strengthened to $204.5 million (up from $135.2M in 2023)

The company expects its current cash position to fund operations into the first half of 2026.

Prime Medicine (Nasdaq: PRME), a biotechnology company focused on developing one-time curative genetic therapies, has announced its participation in the TD Cowen 45th Annual Health Care Conference. The company's President and CEO, Keith Gottesdiener, M.D., will engage in a fireside chat on Monday, March 3, 2025, at 11:10 a.m. ET in Boston, MA.

The presentation will be accessible through a live audio webcast in the 'Events & Presentations' section of Prime Medicine's website. Interested parties can access the replay of the webcast on the company's website for 30 days after the presentation.

Prime Medicine, a biotechnology company specializing in one-time curative genetic therapies, has announced that its President and CEO, Keith Gottesdiener, M.D., will present at the 43rd Annual J.P. Morgan Healthcare Conference. The presentation is scheduled for Tuesday, January 14, 2025, at 3:00 p.m. PT (6:00 p.m. ET) in San Francisco, CA.

A live audio webcast of the presentation will be accessible under the “Events & Presentations” section on the company’s website, www.primemedicine.com. Additionally, a replay of the webcast will be available on the website for 30 days after the presentation.

Prime Medicine reported Q3 2024 financial results and business updates. The company presented initial in vivo data for its Wilson's Disease program and universal liver-targeted LNP at ESGCT, showing up to 80% precise mutation correction. A strategic collaboration with Bristol Myers Squibb brought $110 million upfront with potential for $3.5 billion in milestone payments. The company reported a net loss of $52.5 million and pro-forma cash position of $244.6 million, expected to fund operations into 1H 2026. Prime Medicine remains on track to file IND/CTA for Wilson's Disease in 1H 2026 and report initial data from Phase 1/2 trial of PM359 for CGD in 2025.

Prime Medicine (Nasdaq: PRME) has announced its participation in three upcoming investor conferences in November 2024. The company will engage in fireside chats at Guggenheim's Inaugural Healthcare Innovation Conference in Boston on November 13 at 3:00 p.m. ET, the Stifel 2024 Healthcare Conference in New York on November 18 at 1:15 p.m. ET, and the Jefferies London Healthcare Conference in London on November 19 at 2:30 p.m. GMT. Live audio webcasts will be available on Prime Medicine's website, with replays accessible for 90 days after each event.