Welcome to our dedicated page for Prothena news (Ticker: PRTA), a resource for investors and traders seeking the latest updates and insights on Prothena stock.
Prothena Corporation plc (NASDAQ: PRTA) is described in its own press releases as a late-stage clinical biotechnology company focused on protein dysregulation in neurodegenerative and rare peripheral amyloid diseases. The PRTA news feed on Stock Titan aggregates these company communications, giving investors and observers a single place to follow Prothena’s disclosures and milestones.
In its recent news, Prothena has highlighted progress across a pipeline that includes both wholly-owned and partnered programs. Updates have covered clinical development for Parkinson’s disease through the prasinezumab collaboration with Roche, ATTR amyloidosis with cardiomyopathy via coramitug (formerly PRX004) now being developed by Novo Nordisk, and Alzheimer’s disease programs such as BMS-986446 (formerly PRX005) with Bristol Myers Squibb, PRX012, and the dual Aβ/tau vaccine PRX123. The company has also issued releases on its CYTOPE technology platform, workforce restructuring, and financial results.
Readers of the PRTA news page can review press releases on topics such as Phase 2 and Phase 3 trial plans, Fast Track designations, preclinical data from the TDP-43 CYTOPE program, and corporate actions including an Extraordinary General Meeting to approve a capital reduction to create distributable reserves. Governance and leadership updates, such as changes to the Board of Directors, are also disclosed through these announcements.
By following this curated stream of Prothena’s own news, users can see how the company presents the status of its investigational therapeutics, collaborations with partners like Roche, Novo Nordisk and Bristol Myers Squibb, and its capital and cost structure decisions. The PRTA news page is intended as a convenient starting point for reviewing Prothena’s publicly released information over time.
Prothena Corporation (NASDAQ:PRTA) presented promising data on its Alzheimer’s disease programs at the Alzheimer’s Association International Conference 2021. Highlights include the late-breaking poster on PRX012, demonstrating effective clearance of Aβ plaque in brain tissue, and a dual Aβ-tau vaccine that generates antibodies to target both amyloid and tau pathologies. PRX012 is noted for its high potency and potential for subcutaneous administration, promising improved patient compliance. The Investigational New Drug Application for PRX012 is anticipated in Q1 2022, enhancing Prothena's robust Alzheimer’s portfolio.
Dublin, Ireland, July 20, 2021 - Prothena Corporation plc (NASDAQ:PRTA) announced it will present preclinical data on its Alzheimer’s disease programs at the Alzheimer’s Association International Conference 2021 (July 26-30). The presentations will cover PRX012, a next-generation anti-amyloid beta antibody, and a dual Aβ-tau vaccine. PRX012 aims for improved efficacy and safety, with an IND expected in Q1 2022. The dual vaccine is designed to tackle both Aβ plaques and tau tangles, presenting significant therapeutic potential in addressing Alzheimer's, which currently affects over 5.8 million Americans.
Prothena Corporation and Novo Nordisk announced a definitive agreement for Novo Nordisk to acquire Prothena's clinical stage antibody, PRX004, aimed at treating ATTR cardiomyopathy. This deal includes milestone payments totaling up to $1.2 billion, with $100 million in upfront payments. PRX004, which has completed Phase 1 studies, is designed to deplete amyloid deposits linked to this rare heart disease. Novo Nordisk will focus on advancing PRX004 to address unmet medical needs in cardiac patients.
Prothena Corporation has entered a significant collaboration with Bristol Myers Squibb, receiving $80 million for the exclusive U.S. license of its anti-tau antibody, PRX005, aimed at treating Alzheimer's disease. This agreement marks the initiation of the Phase 1 study for PRX005, which specifically targets the microtubule binding region of tau—key to the progression of Alzheimer’s. With this licensing deal, Prothena's total income from this collaboration rises to $230 million, potentially leading to up to $2.2 billion in future milestone payments.
Dublin-based Prothena Corporation plc (NASDAQ:PRTA) announced participation in a fireside chat at the JMP Securities Life Sciences Conference on June 16, 2021, at 3:00 PM ET. The chat will be accessible via a live webcast on the company’s investor relations website, with a replay available for 90 days post-event. Prothena focuses on developing therapies targeting protein dysregulation related to rare peripheral amyloid and neurodegenerative diseases, including AL amyloidosis, ATTR amyloidosis, Alzheimer’s, and Parkinson’s disease.
Prothena Corporation plc (NASDAQ:PRTA) has appointed Sanjiv K. Patel, MBBS, MA, MBA, to its Board of Directors. With extensive leadership experience, including roles at Relay Therapeutics and Allergan, Patel is expected to guide Prothena through its transition to a fully integrated biotechnology company. The Chairman, Lars Ekman, expressed optimism about Patel's contributions during this transformational phase. Prothena focuses on protein dysregulation and has a promising pipeline targeting various neurodegenerative diseases, including amyloidosis and Alzheimer’s disease.
Prothena Corporation reported a net loss of $36.7 million for Q1 2021, widening from a loss of $23.6 million in Q1 2020. Total revenue reached $0.2 million, a slight increase from $0.1 million year-over-year. R&D expenses rose to $21.1 million, primarily due to higher clinical trial costs for birtamimab and prasinezumab. With cash and equivalents of $345.7 million, the company expects to utilize $51 to $74 million in cash for the full year while revising year-end cash guidance to approximately $316 million. Significant clinical developments include advancements in Phase 3 AFFIRM-AL study and a $60 million milestone from Roche.
Prothena Corporation (NASDAQ:PRTA) has secured a $60 million milestone from Roche following the first patient dosing in the Phase 2b PADOVA study of prasinezumab, targeting early Parkinson's disease. This adds to the $75 million previously received, totaling $135 million in milestone payments from Roche. Prasinezumab, an anti-alpha-synuclein antibody, is in late-stage development after showing efficacy in the Phase 2 PASADENA study. The PADOVA study will enroll about 575 patients, aiming to assess the drug's efficacy and safety, marking a significant advancement in treatment for Parkinson's disease.
Dublin, Ireland—May 7, 2021—Prothena Corporation plc (NASDAQ:PRTA) announced the hiring of two new employees, accompanied by the grant of options to purchase 155,000 ordinary shares at an exercise price of $27.04, based on the closing price on May 3. The options, part of the 2020 Employment Inducement Incentive Plan, will vest over four years, with a quarter vesting after one year and the rest monthly thereafter. Prothena focuses on developing therapeutics for rare peripheral amyloid and neurodegenerative diseases, leveraging extensive scientific expertise.
Prothena Corporation plc (NASDAQ:PRTA) will report its Q1 2021 financial results on May 11, 2021, after U.S. market close. Consistent with past practices, the company will not host a conference call for this release. Prothena specializes in treating rare peripheral amyloid and neurodegenerative diseases, leveraging decades of research in protein dysregulation. Its pipeline includes candidates targeting AL amyloidosis, ATTR amyloidosis, Alzheimer's, Parkinson's, and other related diseases.