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Plus Therapeutics reports news on its CNS oncology business, which combines precision diagnostics with targeted radiopharmaceutical development for central nervous system cancers. Recurring updates cover REYOBIQ™ (rhenium Re186 obisbemeda), a radiotherapeutic program for indications including leptomeningeal metastases and recurrent glioblastoma, as well as clinical and translational presentations, regulatory designations, manufacturing technology transfer and supply-chain partnerships.
The company’s news also covers the commercial expansion of CNSide®, including payer coverage, Medicare enrollment and reimbursement work for its cerebrospinal fluid assay platform. Corporate updates include leadership appointments, equity inducement grants under Nasdaq rules, financial results, capital actions and listing-compliance matters tied to its Nasdaq-traded common stock.
Plus Therapeutics (Nasdaq: PSTV) began manufacturing activities and technology transfer with SpectronRx under a Master Services Agreement to support GMP late-stage clinical supply of REYOBIQ and Rhenium-186.
The agreement adds SpectronRx as a second GMP site, centralizes isotope processing and drug manufacture in one Indiana facility, and aims to advance manufacturing scale-up toward a 2026 target milestone for late-stage clinical supply.
Plus Therapeutics (Nasdaq: PSTV) granted inducement equity awards to Eric J Daniels, M.D., who joined as Chief Development Officer on April 20, 2026. The awards include 20,000 stock options and 20,000 restricted stock units (RSUs), approved under Nasdaq Rule 5635(c)(4).
Options have a 10-year term with an exercise price of $7.30 (fair market value at grant). Options vest over four years; RSUs vest over three years, each subject to continued service.
Plus Therapeutics (Nasdaq: PSTV) announced it has regained compliance with Nasdaq's minimum bid price rule. Nasdaq confirmed the company's closing bid price was at or above $1.00 per share for 10 consecutive business days from April 6, 2026 to April 17, 2026.
Nasdaq advised the matter is closed, restoring full compliance with Listing Rule 5550(a)(2).
Plus Therapeutics (Nasdaq: PSTV) appointed Randy H. Goodman, PhD, MHA, as Vice President, Value Strategy & HEOR, effective April 13, 2026. Dr. Goodman brings 20+ years of payer strategy, HEOR, and policy experience to support CNSide adoption and commercialization of REYOBIQ.
The company granted inducement equity: 4,500 options (10-year term, $5.41 exercise) and 4,500 RSUs, with standard multi-year vesting schedules approved under Nasdaq Rule 5635(c)(4).
Plus Therapeutics (Nasdaq: PSTV) appointed Eric J. Daniels, M.D., MBA as Chief Development Officer, effective April 20, 2026. Dr. Daniels brings more than two decades of clinical development, regulatory strategy, and corporate operations experience to advance REYOBIQ and the company’s CNS-focused radiopharmaceutical pipeline.
The hire follows senior roles including CDO at Kiora Pharmaceuticals, co-founder of Bayon Therapeutics, and CEO of OccuRx, and is positioned to strengthen Plus’s development execution as it advances clinical programs.
Plus Therapeutics (Nasdaq: PSTV) announced the U.S. FDA granted Orphan Drug Designation to REYOBIQ (rhenium Re186 obisbemeda) for the treatment of pediatric malignant gliomas, with the designation scope broadened to include progressive pediatric ependymoma. The company also noted FDA IND clearance for pediatric high-grade glioma and ependymoma and ongoing Phase 1/2 studies.
The designation offers potential benefits including seven years of market exclusivity, tax credits, and regulatory fee exemptions.
Plus Therapeutics (Nasdaq: PSTV) received an AMA PLA CPT code (0640U) for its CNSide® CSF Tumor Cell Enumeration (TCE) test, effective July 1, 2026.
This dedicated billing code establishes a unique reimbursement identifier to support payer claims processing, clinician adoption, national utilization tracking, and the Company’s ongoing U.S. commercial launch of CNSide diagnostics.
Plus Therapeutics (Nasdaq: PSTV) announced Highmark coverage for its CNSide® CSF Tumor Cell Enumeration (TCE) assay, effective April 1, 2026, expanding total covered lives from ~67 million to ~75 million.
The agreement supports patient access, may accelerate clinical adoption, and advances the company toward its 2026 objective of 150 million covered lives.
Plus Therapeutics (Nasdaq: PSTV) granted inducement equity awards on March 26, 2026 to two new employees under its 2015 New Employee Incentive Plan.
The awards total 300,000 stock options (10-year term, $0.243 exercise price) and 300,000 RSUs. Options vest over four years; RSUs vest over three years.
Plus Therapeutics (NASDAQ: PSTV) announced a 1-for-25 reverse stock split effective 12:01 a.m. ET on April 2, 2026, to increase its per-share trading price and comply with Nasdaq's $1.00 minimum bid requirement.
Outstanding shares will be reduced from ~171,550,698 to ~6,862,027, a new CUSIP 72941H806 will be assigned, fractional shares will be paid in cash, and equity awards and warrants will be adjusted.