Arcus Bioscience Stock Price, News & Analysis

Arcus Biosciences (NYSE:RCUS) reported promising Q3 2024 results, highlighting significant progress in its cancer therapy pipeline. Key developments include positive data from the Phase 1/1b ARC-20 study of casdatifan, showing a 34% objective response rate in renal cell carcinoma patients. The company announced a new collaboration with AstraZeneca for combination therapy studies. Financial position remains strong with $1.1 billion in cash and equivalents, providing runway into mid-2027. Revenue reached $48 million for Q3 2024, up from $32 million in Q3 2023, though net loss increased to $92 million from $71 million year-over-year.

Arcus Biosciences (NYSE:RCUS) announced positive results from Part 1 of ARC-10 study evaluating domvanalimab plus zimberelimab (DZ) in non-small cell lung cancer patients. The combination demonstrated a 36% reduction in death risk compared to zimberelimab alone, with median overall survival not yet reached versus 24.4 months for zimberelimab. The DZ combination showed improved progression-free survival of 11.5 months versus 6.2 months, and higher objective response rate of 44.7% versus 35%. Treatment-related adverse events leading to discontinuation were lower in the DZ group (10.5%) compared to chemotherapy (23.5%).

Arcus Biosciences (NYSE:RCUS) announced four accepted abstracts for presentation at the Society for Immunotherapy of Cancer (SITC) Annual Meeting in Houston, November 6-10, 2024. The key highlight is a late-breaking poster presenting data from ARC-10, including overall survival results for domvanalimab plus zimberelimab in front-line NSCLC patients. The study evaluates this combination versus zimberelimab or chemotherapy in patients with PD-L1-high locally advanced or metastatic NSCLC.

Additionally, an oral presentation will showcase data from an Investigator Sponsored Trial examining domvanalimab and zimberelimab in anti-PD-1 refractory hepatocellular carcinoma. The company will discuss ARC-10 results during its earnings call on November 6, 2024.

Arcus Biosciences (NYSE:RCUS), a clinical-stage biopharmaceutical company focused on cancer therapies, has granted equity awards to six new employees. The Compensation Committee approved stock options to purchase 28,600 shares at $17.33 per share (the closing price on October 23, 2024) and restricted stock units for 14,300 shares. These awards were granted under the company's 2020 Inducement Plan, which was approved under NYSE Listed Company Manual Rule 303A.08's inducement exception.

Arcus Biosciences presented promising first clinical data for casdatifan, their HIF-2a inhibitor, in treating metastatic kidney cancer. The Phase 1/1b study (ARC-20) showed a 34% objective response rate (2 responses pending confirmation) and 25% confirmed response rate in the 100mg daily dose expansion cohort of 32 patients. The treatment demonstrated an 81% disease control rate with only 19% primary progression. Safety profile was manageable, with Grade 3 treatment-related adverse events at 42%, mainly including anemia (36%) and hypoxia (9%). The company plans to initiate PEAK-1, their first Phase 3 study, in the first half of 2025.

Arcus Biosciences (NYSE:RCUS), a clinical-stage, global biopharmaceutical company focusing on cancer therapies, has announced a conference call and webcast scheduled for November 6th, 2024, at 2 PM PT / 5 PM ET. The call will discuss the company's third-quarter 2024 financial results and provide a pipeline update for the quarter ended September 30th, 2024.

Investors can join the call by dialing +1 (404) 975-4839 (local) or +1 (833) 470-1428 (toll-free), using Access Code: 940081. Online registration is also available. A live webcast and slide presentation will be accessible through the "Investors & Media" section of the Arcus Biosciences website. A replay of the webcast will be made available after the event.

Arcus Biosciences (NYSE:RCUS), a clinical-stage global biopharmaceutical company focusing on cancer treatments, has announced new employment inducement grants. The Compensation Committee of the company's Board of Directors has granted four new employees options to purchase a total of 24,100 shares of common stock at an exercise price of $17.47 per share, which was the closing price on October 8, 2024. Additionally, these employees received restricted stock units to acquire a total of 12,050 shares of common stock.

These equity awards were granted under the company's 2020 Inducement Plan, which was approved by the Board of Directors in January 2020 in accordance with the "inducement exception" under NYSE Listed Company Manual Rule 303A.08.

Arcus Biosciences (NYSE:RCUS) will present first clinical data from the ARC-20 study at the 2024 EORTC-NCI-AACR Symposium. The oral presentation will highlight data from the 100mg daily monotherapy expansion cohort of ARC-20, a Phase 1/1b study evaluating casdatifan in late-line clear cell renal cell carcinoma (ccRCC). Data will include safety, efficacy, objective response rate, and rate of primary progression.

Arcus is pursuing a broad development program for casdatifan in ccRCC, including the planned initiation of their first Phase 3 study, PEAK-1, in the first half of 2025. The company will also present posters on casdatifan's preclinical evaluation, human pharmacokinetics/pharmacodynamics, and AB801, Arcus's AXL inhibitor.

A conference call to discuss the ARC-20 results will be held on October 24, 2024, at 5:00 AM PT / 8:00 AM ET.

Arcus Biosciences (NYSE:RCUS) has announced a clinical trial collaboration agreement with AstraZeneca to evaluate casdatifan (AB521), Arcus's investigational HIF-2a inhibitor, in combination with volrustomig, AstraZeneca's investigational PD-1/CTLA-4 bispecific antibody, in patients with clear cell renal cell carcinoma (ccRCC). This marks the second clinical collaboration between the two companies.

The study, sponsored and operationalized by AstraZeneca, aims to assess the safety and early efficacy of the combination therapy in advanced ccRCC patients. Arcus believes casdatifan has best-in-class potential based on observed PK and PD profiles and emerging clinical data from their ARC-20 study. The collaboration seeks to improve outcomes for ccRCC patients by combining HIF-2a inhibition with volrustomig.

Under the Gilead and Arcus collaboration agreement, Gilead retains the right to opt-in to development and commercialization for casdatifan after Arcus delivers a qualifying data package.