Rafael Holdings Reports Fourth Quarter and Full Year Fiscal 2025 Financial Results

Rhea-AI Summary

Rafael Holdings (NYSE: RFL) reported fourth-quarter and full-year fiscal 2025 results for the period ended July 31, 2025. Key facts: cash and cash equivalents $52.8M, completion of a $25.0M rights offering (closed June 4, 2025) with a $21.0M backstop by the Jonas family, and consolidation of Cyclo following its March 2025 acquisition. The Data Monitoring Committee recommended continuing Cyclo's pivotal Phase 3 TransportNPC™ study of Trappsol® Cyclo™ after a 48-week review. Fiscal Q4 net loss attributable to Rafael Holdings was $12.1M ($0.28/sh); full-year net loss was $30.5M ($1.04/sh). R&D and G&A expenses increased year over year due to Cyclo and prior consolidations.

Positive

• Cash and cash equivalents of $52.8M as of July 31, 2025
• Closed $25.0M rights offering on June 4, 2025
• Jonas family funded $21.0M backstop commitment
• DMC recommended continuation of Phase 3 TransportNPC study

Negative

• Q4 net loss widened to $12.1M (Q4 prior year $4.5M)
• Full-year net loss of $30.5M for FY2025
• R&D expenses rose to $12.8M for FY2025 from $4.2M
• G&A expenses increased to $13.8M for FY2025 from $8.9M

Insights

Life Sciences / Financial Analyst

DMC continuation and a $25 million rights offering bolster program funding; near-term losses widen due to consolidation.

Cyclo Therapeutics' Phase 3 TransportNPC™ study continued after a 48‑week DMC review, which preserves the pivotal path for Trappsol® Cyclo™ and keeps regulatory timelines intact. The company reported $52.8 million in cash and closed a $25 million rights offering in June, including a $21.0 million backstop by the Jonas family, providing explicit funding to advance the program.

The recent quarter showed a larger net loss of $12.1 million versus $4.5 million year‑ago, driven by consolidation of Cyclo and higher R&D and G&A spend; however, full‑year net loss improved to $30.5 million from $34.4 million last year, helped by non‑recurring items disclosed. These are concrete financials that clarify the current burn profile and capital runway.

Watch the Phase 3 efficacy and safety readouts and milestone timing tied to the TransportNPC™ study, alongside quarterly cash burn and any further financing; near‑term horizon: next clinical milestones and quarterly reports (months ahead). The facts support continued program advancement with funded runway, while short‑term financials reflect acquisition‑related consolidation and higher development costs.

Cyclo Therapeutics’ TransportNPC™ Phase 3 clinical trial for Trappsol^® Cyclo™ for the treatment of Niemann-Pick Disease Type C1, a rare and fatal genetic disease, is continuing at the recommendation of the Data Monitoring Committee (DMC) following their review of prespecified safety and efficacy date at 48 weeks

On August 4, 2025, Joshua Fine was elected as the Company’s Chief Operating Officer

NEWARK, N.J., Oct. 29, 2025 (GLOBE NEWSWIRE) -- Rafael Holdings, Inc. (NYSE: RFL; NYSE American: RFL-W), today reported its financial results for the fourth quarter and full fiscal year 2025 ended July 31, 2025.

“We are pleased with the continued progress of our pivotal Phase 3 TransportNPC™ study evaluating Trappsol^® Cyclo™ for the treatment of Niemann-Pick Disease Type C1, which we believe could provide an important new treatment for option for patients suffering from this rare and fatal genetic disease,” said Howard Jonas, Chief Executive Officer, Executive Chairman and Chairman of the Board of Rafael Holdings. Mr. Jonas added, “We enhanced our financial position with the closing of a $25 million rights offering in June, which positions our Company well to advance the Trappsol^® Cyclo™ program and invest in additional opportunities we may identify. I would also like to take this opportunity to congratulate Joshua Fine on his appointment as the Company’s Chief Operating Officer, Alan Grayson on his addition to our Board of Directors and Markus Sieger on being named as Chair of our Audit Committee. I look forward to their important contributions towards advancing the Company and driving value for all stakeholders.”

Rafael Holdings, Inc. Fourth Quarter Fiscal Year 2025 Financial Results

As of July 31, 2025, we had cash and cash equivalents of $52.8 million. On June 4, 2025, the Company closed a $25 million rights offering, which included the funding of the backstop commitment in the amount of $21.0 million by the Jonas family.

For the three months ended July 31, 2025, we recorded a net loss attributable to Rafael Holdings of $12.1 million, or $0.28 per share, versus a net loss of $4.5 million, or $0.19 per share in the year ago period. The year over year increase in net loss is attributable to the consolidation of Cyclo Therapeutic’s expenses following the acquisition of Cyclo in March 2025 and the activity of Cornerstone and Day Three which were consolidated with Rafael Holdings during fiscal 2024.

Research and development expenses were $7.5 million for the three months ended July 31, 2025, compared to $1.5 million in the year ago period. The year over year increase relates to the inclusion in the current year period of spending at Cyclo following the March 2025 acquisition and the activity of Cornerstone and Day Three which were consolidated with Rafael Holdings during fiscal 2024.

General and administrative expenses were $5.5 million for the three months ended July 31, 2025, compared to $2.3 million in the year ago period. The year over year increase relates to the inclusion of expenses at Cyclo following closing of the acquisition, and the activity of Cornerstone and Day Three, following their consolidation.

Rafael Holdings, Inc. Full Year Fiscal Year 2025 Financial Results

For the twelve months ended July 31, 2025, we recorded a net loss attributable to Rafael Holdings of $30.5 million, or $1.04 per share, versus a net loss of $34.4 million, or $1.45 per share in the year ago period. The year over year decrease in net loss is attributable to in-process R&D expense of $89.9 million related to the acquisition (when we increased our ownership position) of Cornerstone netted with a $31.3 million recovery of receivables from Cornerstone in the year ago period, $5.9 million in unrealized gains on the Company’s investment in Cyclo equity and the inclusion of Cyclo following closing of the acquisition in March 2025 and the activity of Cornerstone and Day Three, following their consolidation.

Research and development expenses were $12.8 million for the twelve months ended July 31, 2025, compared to $4.2 million in the year ago period. The year over year increase relates to the inclusion of spending at Cyclo following the March 2025 acquisition of with Cyclo, and the activity of Cornerstone and Day Three, which were consolidated with Rafael Holdings during fiscal 2024.

For the twelve months ended July 31, 2025, general and administrative expenses were $13.8 million compared to $8.9 million in the same period in the prior year. The year over year increase relates to spending at Cyclo following the acquisition, and the activity of Cornerstone and Day Three, following their consolidation.

About Rafael Holdings, Inc.

Rafael Holdings, Inc. is a biotechnology company that develops pharmaceuticals and holds interests in clinical and early stage companies that develop pharmaceuticals and medical devices. Our lead candidate is Trappsol® Cyclo™, which is being evaluated in clinical trials for the potential treatment of Niemann-Pick Disease Type C1 (“NPC1”), a rare, fatal and progressive genetic disorder. We also hold interests in other clinical-stage and early-stage pharmaceutical development companies and an orthopedic-focused medical device company developing instruments to advance minimally invasive surgeries. Our lead candidate, Trappsol® Cyclo™, is the subject of an ongoing pivotal Phase 3 clinical trial.

Forward Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including without limitation statements regarding our expectations surrounding the potential, safety, efficacy, and regulatory and clinical progress of our product candidates; plans regarding the further evaluation of clinical data; and the potential of our pipeline, including our internal cancer metabolism research programs. These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including, but not limited to, those disclosed under the caption “Risk Factors” in our Annual Report on Form 10-K for the year ended July 31, 2024, and our other filings with the SEC. These factors could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent management’s estimates as of the date of this press release. While we may elect to update such forward-looking statements at some point in the future, we disclaim any obligation to do so, even if subsequent events cause our views to change.

Contact:
Barbara Ryan
Barbara.ryan@rafaelholdings.com
(203) 274-2825

RAFAEL HOLDINGS, INC.
CONSOLIDATED BALANCE SHEETS
(in thousands, except share and per share data)
		July 31, 2025				July 31, 2024
ASSETS
CURRENT ASSETS
Cash and cash equivalents		$	52,769			$	2,675
Available-for-sale securities			—				63,265
Prepaid clinical trial costs			1,045				—
Interest receivable			—				515
Convertible notes receivable, due from Cyclo			—				5,191
Other receivables			1,206				—
Accounts receivable, net of allowance for credit losses of $245 at July 31, 2025 and July 31, 2024			627				426
Inventory			281				—
Prepaid expenses and other current assets			786				430
Total current assets			56,714				72,502
Property and equipment, net			1,596				2,120
Investments – Hedge Funds			—				2,547
Investments – Cyclo			—				12,010
Convertible notes receivable classified as available-for-sale			1,858				1,146
Goodwill			19,939				3,050
Intangible assets, net			994				1,847
In-process research and development			31,575				1,575
Non-current prepaid clinical trial costs			1,399				—
Other assets			34				35
TOTAL ASSETS		$	114,109			$	96,832
LIABILITIES AND EQUITY
CURRENT LIABILITIES
Accounts payable		$	6,893			$	2,556
Accrued expenses			3,304				1,798
Convertible notes payable			614				614
Other current liabilities			66				113
Due to related parties			723				733
Installment note payable			—				1,700
Total current liabilities			11,600				7,514
Accrued expenses, noncurrent			3,895				2,982
Convertible notes payable, noncurrent			78				73
Other liabilities			27				5
Deferred income tax liability			138				—
TOTAL LIABILITIES		$	15,738			$	10,574
COMMITMENTS AND CONTINGENCIES
EQUITY
Class A common stock, $0.01 par value; 35,000,000 shares authorized, 787,163 shares issued and outstanding as of July 31, 2025 and July 31, 2024			8				8
Class B common stock, $0.01 par value; 200,000,000 shares authorized, 50,789,697 issued and outstanding (excluding treasury shares of 101,487) as of July 31, 2025, and 24,142,535 issued and 23,819,948 outstanding (excluding treasury shares of 101,487) as of July 31, 2024			508				238
Additional paid-in capital			322,161				280,048
Accumulated deficit			(232,263	)			(201,743	)
Treasury stock, at cost; 101,487 Class B shares as of July 31, 2025 and July 31, 2024			(168	)			(168	)
Accumulated other comprehensive income related to unrealized income on available-for-sale securities			358				111
Accumulated other comprehensive income related to foreign currency translation adjustment			3,787				3,691
Total equity attributable to Rafael Holdings, Inc.			94,391				82,185
Noncontrolling interests			3,980				4,073
TOTAL EQUITY			98,371				86,258
TOTAL LIABILITIES AND EQUITY		$	114,109			$	96,832

RAFAEL HOLDINGS, INC.
CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (LOSS)
(in thousands, except share and per share data)
	Three Months Ended July 31,								Year Ended July 31,
		2025				2024				2025				2024
Revenues	$	350			$	165			$	917			$	637
Cost of infusion Technology revenue		-				69				106				154
Cost of product revenue		19				-				28				-
G&A Expenses		5,497				2,330				13,781				8,854
R&D Expenses		7,547				1,543				12,823				4,170
In-process research and development expense		-				-				-				89,861
Depreciation and amortization		50				68				288				225
Loss on impairment of goodwill		-				-				3,050				-
Operating Loss		(12,763	)			(3,845	)			(29,159	)			(102,627	)
Interest income		467				606				1,996				2,383
Loss on initial investment in Day Three upon acquisition		-				-				-				(1,633	)
Realized gain on available-for-sale securities		-				251				178				1,772
Realized loss on investment in equity securities		-				-				-				(46	)
Realized gain on investment - Cyclo		-				-				-				424
Unrealized (loss) gain on investment - Cyclo		-				(3,162	)			(5,144	)			37
Unrealized (loss) gain on convertible notes receivable, due from Cyclo		-				1,191				(719	)			1,191
Unrealized gain on investment - Hedge Funds		-				181				-				63
Recovery of receivables from Cornerstone		-				-				-				31,305
Interest expense		(168	)			(163	)			(658	)			(248	)
Other income, net		236				-				310				118
Loss before incomes taxes		(12,228	)			(4,941	)			(33,196	)			(67,261	)
Benefit from taxes		174				87				2,553				2,680
Equity in loss of Day Three		-				-				-				(422	)
Consolidated net loss		(12,054	)			(4,854	)			(30,643	)			(65,003	)
Consolidated net loss		(12,054	)			(4,854	)			(30,643	)			(65,003	)
Net loss attributable to noncontrolling interests		40				(386	)			(123	)			(30,593	)
Net loss attributable to Rafael Holdings, Inc.	$	(12,094	)		$	(4,468	)		$	(30,520	)		$	(34,410	)
Loss per share attributable to common stockholders
Basic and diluted	$	(0.28	)		$	(0.19	)		$	(1.04	)		$	(1.45	)
Weighted average number of shares used in calculation of loss per share - basic and diluted		43,011,360				23,916,839				29,422,221				23,745,516

FAQ

What were Rafael Holdings (RFL) cash balances as of July 31, 2025?

Rafael Holdings reported $52.8 million in cash and cash equivalents as of July 31, 2025.

How much did Rafael Holdings raise in the June 4, 2025 rights offering (RFL)?

The company closed a $25.0 million rights offering on June 4, 2025, including a $21.0 million backstop by the Jonas family.

What is the status of Cyclo Therapeutics' Phase 3 TransportNPC study for Trappsol Cyclo (RFL)?

The Data Monitoring Committee recommended continuing the pivotal Phase 3 TransportNPC study after a 48-week safety and efficacy review.

What were Rafael Holdings' reported net losses for Q4 and FY2025 (RFL)?

RFL reported a Q4 net loss of $12.1M ($0.28 per share) and a full-year net loss of $30.5M ($1.04 per share) for fiscal 2025.

Why did Rafael Holdings' R&D and G&A expenses increase in fiscal 2025?

Expenses rose due to consolidation of Cyclo after the March 2025 acquisition and the continued activity of Cornerstone and Day Three following prior consolidations.