Welcome to our dedicated page for Relief Hldg news (Ticker: RLFTF), a resource for investors and traders seeking the latest updates and insights on Relief Hldg stock.
Relief Therapeutics Holding SA (OTCQB: RLFTF), historically known as Relief Therapeutics, regularly issues news updates covering its biopharmaceutical pipeline, corporate milestones, and, more recently, its transformation into MindMaze Therapeutics Holding SA through a business combination with NeuroX Group SA. Company press releases describe a focus on rare dermatological, metabolic, and respiratory diseases, along with digital neurotherapeutics and an AI-powered brain health platform following the combination.
News items for RLFTF include clinical and regulatory developments such as FDA designations and meeting outcomes for RLF-TD011 in epidermolysis bullosa, and pivotal bioequivalence study results for RLF-OD032, a liquid sapropterin formulation for phenylketonuria. Investors and observers can also find updates on corporate governance events like annual general meetings, half-year and annual report publications, and shareholder approvals for strategic transactions.
Coverage further extends to transaction-related announcements, including the proposed and completed business combination with NeuroX, details on share exchanges, and the renaming of the company to MindMaze Therapeutics Holding SA. Subsequent communications describe the combined company’s activities in digital neurorehabilitation and neurological care, while noting that it continues to manage Relief’s preexisting biopharmaceutical assets.
By following RLFTF news, readers can track the evolution of Relief’s rare disease programs, its regulatory interactions, and the integration of its portfolio into the broader MindMaze Therapeutics platform. This news stream provides context on how the company positions its therapies and digital technologies within the rare disease and neurology landscapes.
Relief Therapeutics has appointed Christopher Wick as the Senior Director, Head of U.S. Sales, to strengthen its U.S. expansion efforts. Wick, with over 20 years in pharmaceutical sales, previously led successful teams at Alexion Pharmaceuticals and held key roles at GlaxoSmithKline and Novartis. His experience will support the planned launch of pharmaceutical treatments, including ACER-001 for Urea Cycle Disorders, with a PDUFA date of June 5, 2022. The company aims to boost its U.S. market presence driven by its recent acquisitions and strategic collaborations.
Relief Therapeutics announced the filing of Amendment No. 1 to its Registration Statement on Form 20-F with the SEC. This aims to register the company as a reporting entity under the Securities Exchange Act of 1934 and convert its Level 1 ADR program to Level 2, facilitating a future Nasdaq listing. However, there is no assurance that the registration will be effective or that the Nasdaq listing will occur. Notably, the filing does not involve any securities offering, hence no proceeds will be received from this ADR program.
Relief Therapeutics has reported results from its clinical trial of Sentinox, a nasal spray intended for SARS-CoV-2 infected patients. Although the primary endpoint was not met due to a small sample size, a positive trend in efficacy was observed, with a near 90% viral load reduction in patients treated three times daily. Negativization rates were significantly higher in the treatment group at day six. Overall, Sentinox demonstrated a favorable safety profile, suggesting its potential as a therapeutic option against viral infections.
Relief Therapeutics has signed a binding term sheet with Meta Healthcare Ltd. to acquire worldwide commercialization rights (excluding the UK and Ireland) for a novel dosage form of a prescription drug approved by the FDA for treating phenylketonuria (PKU). This agreement, expected to enhance Relief's PKU GOLIKE(R) product portfolio, includes responsibilities for bioequivalence studies and regulatory submissions. The product's launch in the U.S. and Europe is anticipated in the first half of 2024, following necessary regulatory approvals.
Relief Therapeutics announced that its collaboration partner, NRx Pharmaceuticals, received approval from the National Institutes of Health to continue the phase 3 trial of aviptadil for critical COVID-19 patients. The review by the Data Safety and Monitoring Board revealed no new safety concerns, allowing enrollment to expand from 448 to 640 patients. The trial's success could lead to a New Drug Application for aviptadil. Relief's diverse pipeline also includes partnerships for other treatments.
Relief Therapeutics has filed for a trademark of RLF-100 with the USPTO, expected to be registered by late April. This trademark will protect the drug's use in treating a variety of diseases, including respiratory and viral infections. The application faced no opposition, allowing for swift registration. RLF-100 is currently in late-stage clinical trials for COVID-19 related acute respiratory distress syndrome, having received FDA Fast Track Designation. This signifies progress in potential therapeutic applications amid ongoing health challenges.
Relief Therapeutics announces the appointment of Michelle Lock to its Board of Directors. Lock brings nearly 30 years of biopharmaceutical sales and commercialization experience from her roles at Covis Pharma, Acceleron Pharma, and Bristol-Myers Squibb. Her expertise aims to bolster Relief's growth strategy and advance its product pipeline, which includes RLF-100 for respiratory issues and ACER-001 for Urea Cycle Disorders. This addition increases the Board to five members, highlighting Relief's commitment to enhancing its operational leadership.
Relief Therapeutics announced that its collaboration partner Acer Therapeutics received a new patent (11,202,767) for ACER-001, covering methods of use related to this treatment for Urea Cycle Disorders (UCDs) and Maple Syrup Urine Disease (MSUD). This adds to a previous patent (11,154,521) for the pharmaceutical composition of ACER-001, with both patents expiring in 2036. Acer's New Drug Application (NDA) for ACER-001 is under review, with a target action date of June 5, 2022.
Relief Therapeutics Holding SA announced key resolutions approved at its Extraordinary General Meeting on January 28, 2022, with over 85% support. Notably, Michelle Lock was elected to the Board of Directors, bringing extensive experience from Acceleron Pharma. The meeting also approved a total compensation of CHF 2,500,000 for board members for the current term and revised the Articles of Association. Relief's lead drug candidate, RLF-100, is in late-stage testing for COVID-19 respiratory issues, while partnerships expand its pipeline for rare diseases.
Relief Therapeutics Holding SA announced that its partner, NRx Pharmaceuticals, received a safety report on aviptadil use in COVID-19 patients under the Federal Right to Try Law. Out of 19 treated patients, three died while 16 (84%) were alive by January 22, 2022. The report noted no serious adverse events during the Omicron surge. Relief focuses on developing therapies for serious conditions, with aviptadil in late-stage testing for respiratory failure due to COVID-19, alongside other pipeline projects including ACER-001.