Vaping Expected to Increase COPD Health and Economic Burden by 2050

Rhea-AI Summary

ResMed presented 18 supported studies at ERS 2024, including research projecting the impact of vaping, smoking, and air pollution on COPD in Western Europe. Key findings include:

- 88.7 million new COPD hospitalizations projected across Western Europe between 2019-2050
- Vaping projected to incur almost €30 billion additional costs by 2050
- €4.9 trillion projected cumulative cost to support COPD lung conditions by 2050
- 16% projected reduction in risk of death after severe exacerbation for COPD patients using home NIV support

The research highlights the significant health and economic burden of COPD, exacerbated by environmental and behavioral factors. Home non-invasive ventilation (NIV) was found to reduce mortality risk in COPD patients.

Positive

• ResMed-supported research presented at ERS 2024 provides valuable projections on COPD burden
• Home non-invasive ventilation (NIV) shown to reduce mortality risk in COPD patients by 16% following severe exacerbations
• Study involved nearly 50,000 adults with COPD treated via home NIV, providing robust data

Negative

• Vaping projected to incur almost €30 billion additional direct and indirect costs by 2050
• 88.7 million new COPD hospitalizations projected across Western Europe between 2019-2050
• Annual direct and indirect costs of COPD projected to reach over €170 billion by 2050
• Cumulative cost to support COPD lung conditions projected to reach €4.9 trillion by 2050
• Vaping expected to increase number of COPD exacerbations by 1.6 million cumulatively by 2050

Insights

Medical Research Analyst

This study projects a significant increase in COPD burden due to vaping, smoking and air pollution in Western Europe. Key findings include:

• 88.7 million new COPD hospitalizations projected by 2050
• Vaping alone expected to incur €30 billion in additional costs
• €4.9 trillion cumulative cost for COPD support by 2050
• 16% reduction in mortality risk for COPD patients using home NIV

These projections highlight the urgent need for public health interventions targeting risk factors like vaping and air pollution. The potential economic impact is substantial, emphasizing the importance of preventive measures and early intervention strategies for COPD management.

Health Economist

The projected economic burden of COPD in Western Europe is alarming. By 2050, annual costs are expected to reach €170 billion, with a cumulative cost of €4.9 trillion. Vaping alone is forecast to add €3.78 billion annually in medical and societal costs. This substantial financial impact underscores the need for:

• Increased investment in COPD prevention programs
• Development of cost-effective treatment strategies
• Policy measures to reduce vaping and improve air quality

The economic implications extend beyond healthcare, affecting productivity and overall economic growth. Policymakers and healthcare systems must prioritize COPD prevention and management to mitigate these projected costs.

Public Health Expert

This research highlights the growing public health crisis of COPD in Western Europe. Key concerns include:

• Vaping's emerging role in COPD burden, previously underestimated
• Projected 0.3% increase in exacerbations due to vaping (1.6 million cases)
• 0.2% increase in hospitalizations (190,000 cases) attributed to vaping
• Positive impact of home NIV in reducing mortality risk

These findings call for urgent action in public health policy, including stricter regulation of vaping products, enhanced air quality measures and increased access to home NIV for COPD patients. Education campaigns on COPD risks and early symptom recognition are crucial. The projected burden necessitates a comprehensive, multi-faceted approach to COPD prevention and management.

New ResMed-supported research presented at ERS 2024 projects future Chronic Obstructive Pulmonary Disease (COPD) burden in Western Europe, accounting for increased air pollution, tobacco smoking, and vaping, with Non-Invasive Ventilation (NIV) enhancing survival rates.

• 88.7 million new COPD hospitalizations projected across Western Europe between 2019 - 2050
• Vaping projected to incur almost €30 billion additional direct and indirect costs by 2050
• €4.9 trillion projected cumulative cost to support COPD lung conditions by 2050
• 16% projected reduction in risk of death after a severe exacerbation for COPD patients using home NIV support

SAN DIEGO and VIENNA, Sept. 10, 2024 (GLOBE NEWSWIRE) -- ResMed presented 18 supported studies at ERS 2024, including research that projects vaping, smoking, and air pollution will substantially increase the economic and public health burden of COPD in Western Europe. Annual direct and indirect costs are projected to reach over €170 billion by 2050, costing Western European economies over €4.9 trillion cumulatively by 2050. Vaping alone is forecast to require an additional €3.78 billion annually to support its impact on medical care and societal costs.

COPD poses a significant health and economic burden, further exacerbated by environmental and behavioral changes such as air pollution and vaping. Previous modeling work has focused on quantifying the burden of COPD across North America, accounting for tobacco smoking and air pollution¹. The ResMed-supported research aimed to extend this US modeling by also accounting for the effects of vaping on the COPD burden in Western Europe².

The results of this pertinent research were presented at ERS 2024 by Elroy Boers, PhD, Lead Health Research Scientist, ResMed. The model projected that, in addition to smoking and air pollution, vaping is going to have a notable economic and health impact on the burden of COPD into 2050, both cumulatively and annually.

2050 outcomes describing the relative increase associated with vaping (vs. the scenario without vaping) were concluded to be:

• Direct costs are projected to relatively increase by 0.5% (cumulative) and 2.1% (annual) – representing a cumulative increase of €10 billion.
• Indirect costs are projected to relatively increase by 0.7% (cumulative) and 2.3% (annual) – representing a cumulative increase of €20 billion.
• The number of exacerbations is estimated to relatively increase by 0.3% or 1.6 million (cumulative) and 1.8% (annual)
• The number of hospitalizations is projected to increase by 0.2% or 190,000 (cumulative) and 3.3% (annual).

“To avoid escalating costs to public finances, additional strain on health services, and reduce loss of life from COPD, much greater action is required. Public health and advocacy efforts targeting known risk factors such as smoking, vaping, and ambient and household air pollution may be critical to prevent this anticipated burden,” said ResMed Chief Medical Officer Carlos M. Nunez, M.D.

In a separate ResMed-supported study presented by Professor Jean-Louis Pépin, Grenoble Alpes University, France, the role of home non-invasive Ventilation (NIV) support in managing COPD was explored. The study found that continued use of home NIV significantly reduces risk of death from COPD flare-ups (exacerbations), with a 16% reduction in mortality risk following severe exacerbations and a 12% reduction for those without exacerbations. The study involved nearly 50,000 adults with COPD who were treated via home NIV. The multistate model analysis estimated the impact of NIV continuation versus cessation on transitions between three different disease states (without severe exacerbation, severe exacerbation, and death).

“The positive impact of home NIV in reducing risk of death offers some comfort for those millions of people already suffering from COPD and those who will suffer in years to come. However, proactive work now on the part of potential patients and their loved ones to learn and recognize symptoms early, as well as preventative steps to reduce risk factors, will go a long way toward positively impacting hundreds of millions of lives worldwide,” Nunez continued. “Education and meaningful action are essential to curbing the number of people impacted by COPD and life-threatening events caused by these conditions.”

Complete list of ResMed-supported studies presented at ERS 2024:

• The modified Baveno classification for obstructive sleep apnoea management
• Impact of home NIV on severe exacerbations and survival in COPD: a French nationwide cohort study using multistate models
• Light, latitude and Epworth Sleepiness Scale in the European Sleep Apnea database - a daring proposal
• The economic and health burden of COPD in Western Europe through 2050: a scenario analysis based on two large data sources
• Role of Partnership in PAP Therapy Adoption in Obstructive Sleep Apnoea
• A negative effect by ATC N-class treatment in OSA patients with concomitant psychiatric disease: an ESADA cohort study.
• Association of sleep-related hypoxia with survival in patients with non-small cell lung cancer – the NEOSAS-GFPC study group
• Adaptive servo-ventilation (ASV) in patients with central or complex sleep apnea and associated cardiovascular comorbidities: the READ-ASV registry
• Effect of adaptive servo-ventilation on cardiac repolarization in patients with myocardial infarction and sleep-disordered breathing
• Effect of non-respiratory arousals on residual sleepiness in CPAP-treated OSA patients
• The association between behavioural clusters and short-term PAP usage in OSA
• PAP use in OSA patients with and without insomnia
• Usage of adaptive servo-ventilation (ASV): results from the READ-ASV registry
• A scenario-based modelling study to project the future burden of COPD in Western Europe accounting for air pollution, tobacco smoking, and e-cigarette vaping
• Obstructive Sleep Apnoea and C-reactive protein levels: Data from the ESADA
• Preserved ratio impaired spirometry and OSA may contribute to cardio-metabolic complications: evidence from the ESADA cohort
• Comparisons of cardiovascular risk scores in patients with obstructive sleep apnea - the European Sleep Apnea Database (ESADA)
• Effect of CPAP on circulating levels of MPO and MMP-9 in adults with coronary artery disease and obstructive sleep apnoea: the RICCADSA randomized controlled trial

About ResMed
At ResMed (NYSE: RMD, ASX: RMD) we pioneer innovative solutions that treat and keep people out of the hospital, empowering them to live healthier, higher-quality lives. Our digital health technologies and cloud-connected medical devices transform care for people with sleep apnea, COPD, and other chronic diseases. Our comprehensive out-of-hospital software platforms support the professionals and caregivers who help people stay healthy in the home or care setting of their choice. By enabling better care, we improve quality of life, reduce the impact of chronic disease, and lower costs for consumers and healthcare systems in more than 140 countries. To learn more, visit ResMed.com and follow @ResMed.

For Media                                                                                
Emily Yandle                                                
ResMedUK@teamlewis.com                                

Julia Moser                                                
news@resmed.com                                        

¹ E. Boers, A. Allen, A. Benjafield, M. Barrett, and A. Malhotra. The Economic and Health Burden of COPD in North America: Forecasting Through 2050 (abstract). Am J Respir Crit Care Med2023;207:A3593.

² E. Boers, A. Allen, A. Benjafield, L.E. Crotty Alexander, A. Malhotra and M. Barrett. A scenario-based modeling study to project the future burden of COPD in Western Europe accounting for air pollution, tobacco smoking, and e-cigarette vaping. (abstract). ERS 2024.

FAQ

What is the projected economic impact of vaping on COPD in Western Europe by 2050?

According to the ResMed-supported research presented at ERS 2024, vaping is projected to incur almost €30 billion in additional direct and indirect costs related to COPD in Western Europe by 2050.

How many new COPD hospitalizations are expected in Western Europe between 2019 and 2050?

The research projects 88.7 million new COPD hospitalizations across Western Europe between 2019 and 2050.

What is the cumulative cost projected to support COPD lung conditions in Western Europe by 2050?

The cumulative cost to support COPD lung conditions in Western Europe is projected to reach €4.9 trillion by 2050.

How does home non-invasive ventilation (NIV) affect mortality risk in COPD patients?

According to the ResMed-supported study, home NIV support reduces the risk of death by 16% following severe exacerbations in COPD patients.

What factors are contributing to the increased COPD burden in Western Europe, according to the RMD research?

The ResMed-supported research indicates that vaping, smoking, and air pollution are substantially increasing the economic and public health burden of COPD in Western Europe.