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Atrium Therapeutics develops RNA therapeutics designed for targeted delivery to heart tissue. The biopharmaceutical company focuses on precision cardiology programs for rare genetic cardiomyopathies, including candidates ATR 1072 for PRKAG2 syndrome and ATR 1086 for PLN cardiomyopathy, and uses ligand-based targeting approaches with oligonucleotide-based therapies.
Recurring Atrium news covers RNA delivery-platform development, cardiology research collaborations, clinical and regulatory preparation, capital-structure updates and governance matters such as equity inducement grants. Company updates also include milestone activity under its global cardiovascular collaboration with Bristol Myers Squibb and public-company developments following Atrium's launch as an independent Nasdaq-listed issuer.
Avidity Biosciences (Nasdaq: RNA) announced its participation in several virtual scientific meetings to present advancements in its novel Antibody Oligonucleotide Conjugates (AOCs™) platform. Key presentations include:
- TIDES USA 2020 on Sept. 16
- OTS 2020 on Sept. 28
- Next Generation Protein Therapeutics Summit on Nov. 5
- TIDES Europe on Nov. 13
- Neuromuscular Drug Development Summit on Dec. 3
CEO Art Levin highlighted AOC 1001's expected entry into Phase 1/2 trials for myotonic dystrophy type 1, aiming to address serious genetic diseases.
Avidity Biosciences (Nasdaq: RNA) announced a collaboration to support END-DM1, a natural history study aimed at understanding disease progression in myotonic dystrophy type 1 (DM1). The study will enroll approximately 650 participants across the U.S. and Europe, helping inform the development of Avidity's lead program, AOC 1001. This program aims to provide a disease-modifying treatment for DM1 by reducing harmful DMPK mRNA levels. AOC 1001 is scheduled for a Phase 1/2 clinical trial initiation in 2021.
Avidity Biosciences, Inc. (Nasdaq: RNA) announced that CEO Sarah Boyce will participate in a fireside chat at the 2020 Wells Fargo Virtual Healthcare Conference on September 10 at 9:00 am PT. The event will be held virtually, with a live webcast available on Avidity's website. A replay of the chat will be archived for 60 days. Avidity is focused on developing Antibody Oligonucleotide Conjugates (AOCs) aimed at treating serious diseases, including myotonic dystrophy type 1 and other muscle conditions.
Avidity Biosciences, Inc. (Nasdaq: RNA) reported significant progress in Q2 2020, following its IPO on June 16, 2020, which raised $298.1 million. The company is advancing its pipeline of Antibody Oligonucleotide Conjugates (AOCs™), aiming to initiate three first-in-human studies by 2022. As of June 30, 2020, cash and cash equivalents reached $352.4 million, up from $94.6 million at the end of 2019. Collaboration revenue rose to $1.5 million in Q2 2020, compared to $0.2 million in Q2 2019. R&D expenses increased to $9.0 million, reflecting intensified research efforts.
Avidity Biosciences (Nasdaq: RNA) announced the appointment of Jae Kim, M.D., as Chief Medical Officer on July 27, 2020. Dr. Kim will oversee the expansion of Avidity's Antibody Oligonucleotide Conjugates (AOCs™) pipeline, adding his extensive experience in monoclonal antibody and oligonucleotide development. Previously, he held senior roles at Alnylam Pharmaceuticals and MyoKardia, contributing significantly to clinical developments. Avidity aims to leverage AOCs for treating serious diseases, with a focus on muscle-related disorders, through innovative RNA-targeted therapies.
Avidity Biosciences, Inc. (Nasdaq: RNA) announced the successful closing of its initial public offering, issuing 16,560,000 shares of common stock at $18.00 per share, garnering approximately $298.1 million in gross proceeds. This amount includes the full exercise of an underwriters' option for an additional 2,160,000 shares. The offering was facilitated by Cowen, SVB Leerink, Credit Suisse, and Wells Fargo Securities. Avidity is developing a new class of therapies called Antibody Oligonucleotide Conjugates, with a focus on treating serious diseases, including myotonic dystrophy type 1.