SCYNEXIS Reports First Quarter 2026 Financial Results and Provides Corporate Update
Rhea-AI Summary
SCYNEXIS (NASDAQ:SCYX) reported Q1 2026 results and a major pipeline expansion. The company acquired SCY-770, an oral AMPK activator for ADPKD with FDA Orphan Drug designation, and plans a Phase 2 study starting Q4 2026 with early efficacy data expected in H2 2027.
SCYNEXIS advanced antifungal SCY-247, completed oral Phase 1, began IV Phase 1 dosing, and opened an expanded access program. A March private placement delivered about $37.2 million net, supporting a cash runway to mid-2029. GSK’s planned BREXAFEMME relaunch could generate up to approximately $146 million in annual net sales milestones.
Positive
- Private placement raised approximately $37.2 million net, with up to $52.2 million more if warrants exercised
- Quarter-end cash, cash equivalents and investments of $72.4 million, plus about $16 million received April 1
- Cash runway extended to mid-2029, surpassing planned SCY-770 Phase 2 completion
- Acquisition of SCY-770, an AMPK activator for ADPKD with FDA Orphan Drug designation
- Planned Phase 2 proof-of-concept study for SCY-770 in Q4 2026 with H2 2027 readout
- SCY-247 granted FDA QIDP, Fast Track and Orphan Drug designations
- Completion of Phase 1 oral SCY-247 and initiation of IV Phase 1 with topline data expected Q3 2026
- Expanded access program opened for oral SCY-247 for patients with limited or no options
- Potential to receive up to approximately $146 million in annual net sales milestones from BREXAFEMME relaunch by GSK
Negative
- Research and development expenses rose to $12.4 million, up 140% from $5.1 million year over year
- Includes $8.0 million IPR&D expense for the SCY-770 acquisition in Q1 2026
- SG&A expenses increased 23% to $4.6 million, including a $0.8 million write-off of offering costs
- Total other line swung to $4.4 million expense from $3.2 million income in Q1 2025
- Fair value adjustment on warrant liabilities resulted in a $5.2 million loss versus a $2.9 million gain a year earlier
News Market Reaction – SCYX
In the May 12 session, SCYX declined 5.35%, reflecting a notable negative market reaction. Argus tracked a peak move of +2.4% during that session. Argus tracked a trough of -14.1% from its starting point during tracking. Our momentum scanner triggered 6 alerts that day, indicating moderate trading interest and price volatility.
Data tracked by StockTitan Argus on the day of publication.
Key Figures
Previous Earnings Reports
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Mar 04 | Full-year results | Neutral | +2.3% | Reported 2025 results, highlighted $24.8M GSK payment and $56.3M cash. |
| Nov 05 | Q3 2025 earnings | Neutral | -5.5% | Outlined Q3 2025 metrics and GSK payment expectations, with cash runway over two years. |
| Aug 13 | Q2 2025 earnings | Neutral | -5.2% | Reported Q2 2025 results and MARIO Phase 3 progress plus SCY‑247 plans. |
| May 15 | Q1 2025 earnings | Neutral | -19.3% | Detailed Q1 2025 loss, cash runway into Q3 2026, and ibrexafungerp developments. |
| Mar 12 | Full-year 2024 | Neutral | -5.9% | Full-year 2024 loss, $75.1M cash, and SCY‑247 Phase 1 progress outlined. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Tag-specific earnings history shows an average move of -6.71%, suggesting SCYX often trades lower around financial updates, though reactions have varied in magnitude.
Over the last year, SCYNEXIS earnings releases have combined financial updates with pipeline milestones. Prior events highlighted cash balances of $75.1M at 2024 year-end and $56.3M at 2025 year-end, along with a GSK $24.8M payment and advancing SCY‑247. Today’s Q1 2026 release extends this trajectory with the SCY‑770 acquisition, larger R&D spend of $12.4M, and a strengthened cash position of $72.4M plus private placement proceeds targeting runway into mid‑2029.
Key Terms
autosomal dominant polycystic kidney disease medical
amp-activated protein kinase medical
orphan drug designation regulatory
expanded access program regulatory
qualified infectious disease product regulatory
fast track regulatory
warrant liabilities financial
net sales milestones financial
AI-generated analysis. How Rhea-AI works. Not financial advice.
- Completed transformative acquisition of PXL-770, (now SCY-770), an innovative, highly selective, direct AMPK activator for the treatment of autosomal dominant polycystic kidney disease (ADPKD)
- A Phase 2 proof-of-concept study of SCY-770 in ADPKD patients is anticipated to begin in Q4 2026 with an early efficacy readout anticipated in the second half of 2027
- Completed a private placement with net proceeds of approximately
$37.2 million , after deducting placement agent fees and other transaction related expenses, with certain new and existing institutional and accredited investors. Approximately$24 million of the proceeds were received on March 31st with the balance received on April 1st - SCYNEXIS announced dosing of the first patient using the intravenous (IV) formulation of SCY-247 in a Phase 1 study and plans to report topline data in the third quarter of 2026; SCYNEXIS is accepting requests for granting access to oral SCY-247 via expanded access program
- GSK is committed to the relaunch of Brexafemme which has the potential to provide up to approximately
$146 million in annual net sales milestones. - SCYNEXIS ended Q1 2026 with cash, cash equivalents and investments of
$72.4 million , this coupled with the approximately$16.0 million in proceeds received on April 1st extends SCYNEXIS’ cash runway to mid-2029
JERSEY CITY, N.J., May 11, 2026 (GLOBE NEWSWIRE) -- SCYNEXIS, Inc. (NASDAQ: SCYX), a clinical-stage biotechnology company dedicated to advancing innovative solutions for severe rare diseases, today reported financial results for the first quarter ended March 31, 2026.
“Following our recent acquisition of SCY-770, we plan to initiate a Phase 2 proof-of-concept study in ADPKD patients in Q4 2026 to demonstrate the potential of this highly differentiated molecule, which targets multiple key drivers of disease progression,” said David Angulo, M.D., President and Chief Executive Officer. “We would like to thank our existing and new investors who participated in our recent private placement financing. Combined with our existing cash position, this additional capital significantly extends our cash runway to the middle of 2029 approximately one year beyond the anticipated completion of the Phase 2 study for SCY-770.”
“As we move ahead with the SCY-770 clinical program, we also continue to make progress with our second generation fungerp, SCY-247. After completion of the Phase 1 studies with the oral formulation of SCY-247, we are now accepting requests for access to this innovative antifungal for patients with limited or no other treatment options via our expanded access program. We also anticipate announcing topline Phase 1 data of the IV formulation of SCY-247 in the third quarter of 2026.”
Corporate Update:
- On March 31, 2026, SCYNEXIS announced that it entered into a securities purchase agreement with certain new and existing institutional and accredited investors for net proceeds of approximately
$37.2 million , after deducting placement agent fees and transaction-related expenses, and up to an additional$52.2 million in gross proceeds if associated common warrants are fully exercised. The private placement closed on April 1, 2026.
SCY-770 Development Program Update
- On March 31, 2026, SCYNEXIS announced that it entered into a definitive agreement with Poxel S.A. to acquire PXL-770 (now SCY-770). SCY-770 is a novel, highly selective, direct AMP-activated protein kinase (AMPK) activator for the treatment of ADPKD, the leading genetic cause of end-stage renal failure. SCY-770 is designed to address many of the underlying drivers of ADPKD by reducing cyst growth and disease progression. SCY-770 is an oral therapy that has been evaluated in eight clinical trials, with a favorable safety profile. SCYNEXIS expects to begin a Phase 2 proof-of-concept study in ADPKD patients in Q4 2026, with an anticipated early efficacy readout in the second half of 2027. SCY-770 has been granted Orphan Drug Designation by the U.S. Food and Drug Administration (FDA).
SCY-247 Development Program Update
- Presented 9 papers at the European Society of Clinical Microbiology and Infectious Diseases Conference (ESCMID) in Munich in April, highlighting the positive pre-clinical and Phase 1 clinical data for SCY-247.
- In response to patients’ needs and physicians’ requests, and now with a completed Phase 1 study confirming adequate tolerability and achievement of preliminary target exposures with oral SCY-247, SCYNEXIS is accepting requests under the expanded access program to facilitate access to this innovative antifungal for patients with limited or no other treatment options.
- On February 26th, SCYNEXIS announced the initiation of dosing in a Phase 1 study with the IV formulation of SCY-247, with topline data expected in the third quarter of 2026. SCYNEXIS continues to explore non-dilutive funding opportunities to support the further development of SCY-247.
- SCYNEXIS presented data highlighting SCY-247 at the inaugural Interdisciplinary Meeting on Antimicrobial Resistance and Innovation (IMARI), which took place from January 28-30, 2026, in Las Vegas, Nevada. An oral presentation was included in the Plenary session “New Antimicrobial Agents in The Pipeline: Early Clinical Development”.
- The U.S. Food and Drug Administration (FDA) granted the Company Qualified Infectious Disease Product (QIDP) Fast Track and Orphan Drug Designations for SCY-247.
Ibrexafungerp / GSK Update
- GSK is committed to the relaunch of BREXAFEMME, and following its relaunch, SCYNEXIS has the potential to receive up to approximately
$146 million in annual net sales milestones.
First Quarter 2026 Financial Results
Research and development expenses for the three months ended March 31, 2026, were
SG&A expenses for the three months ended March 31, 2026, increased to
Total other expenses was
Cash Balance
Cash, cash equivalents and investments totaled
About SCYNEXIS
SCYNEXIS, Inc. (NASDAQ: SCYX) is a clinical stage biotechnology company dedicated to advancing innovative solutions for severe rare diseases. SCY-770 is being developed for the treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) and has been granted Orphan Drug designation. SCYNEXIS’s proprietary antifungal platform “fungerps” includes BREXAFEMME® (ibrexafungerp tablets), the first approved representative of this novel class, which has been licensed to GSK, and SCY-247, currently in clinical stages of development. For more information, visit www.scynexis.com.
Forward-Looking Statements
Statements contained in this press release regarding expected future events or results are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, including but not limited to statements regarding: the anticipated initiation of the SCY-770 Phase 2 study in Q4 of 2026 and the anticipated early efficacy readout in the second half of 2027, the plans to report topline data from the Phase 1 IV trial of SCY-247 in the second half of 2026 and the statements concerning expected extension of the company’s cash runway to the middle of 2029, and other statements identified by words such as “will,” “potential,” “could,” "can,” “believe,” “intends,” “continue,” “plans,” “expects,” “anticipates,” “estimates,” “may,” other words of similar meaning or the use of future dates. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to, risks inherent in regulatory and other costs in developing products. For the Company, this includes the future prospects of the Company’s SCY-770 program, the timing and results of the Company’s anticipated Phase 2 proof-of-concept clinical study evaluating SCY-770, stock price volatility and uncertainties relating to the financial markets, the medical community and the global economy, and the impact of instability in general business and economic conditions, including changes in inflation and interest rates. These and other risks are described more fully in the Company’s filings with the Securities and Exchange Commission (the “SEC”), including without limitation, its most recent Annual Report on Form 10-K filed on March 4, 2026, including under the caption "Risk Factors,” and in other filings the Company makes with the SEC from time to time. All forward-looking statements contained in this press release speak only as of the date on which they were made. The Company undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.
CONTACT:
Investor Relations
John Fraunces
LifeSci Advisors
Tel: 917-355-2395
jfraunces@lifesciadvisors.com
SCYNEXIS, INC.
UNAUDITED CONDENSED CONSOLIDATED BALANCE SHEETS
(in thousands, except share and per share data)
| March 31, 2026 | December 31, 2025 | |||||||
| Assets | ||||||||
| Current assets: | ||||||||
| Cash and cash equivalents | $ | 36,671 | $ | 21,259 | ||||
| Short-term investments | 22,592 | 18,772 | ||||||
| Prepaid expenses and other current assets | 919 | 263 | ||||||
| Restricted cash | 80 | 80 | ||||||
| Deferred offering costs | 2,429 | — | ||||||
| Total current assets | 62,691 | 40,374 | ||||||
| Investments | 13,153 | 16,247 | ||||||
| Deferred offering costs | — | 533 | ||||||
| Restricted cash | 109 | 109 | ||||||
| Operating lease right-of-use asset | 1,673 | 1,764 | ||||||
| Total assets | $ | 77,626 | $ | 59,027 | ||||
| Liabilities and stockholders’ equity | ||||||||
| Current liabilities: | ||||||||
| Accounts payable | $ | 5,632 | $ | 2,225 | ||||
| Accrued expenses | 1,529 | 2,791 | ||||||
| Asset Purchase Agreement payable | 8,000 | — | ||||||
| Deferred revenue | 235 | 235 | ||||||
| Operating lease liability, current portion | 504 | 483 | ||||||
| Total current liabilities | 15,900 | 5,734 | ||||||
| Warrant liabilities | 18,862 | 2,225 | ||||||
| Operating lease liability | 1,557 | 1,692 | ||||||
| Total liabilities | 36,319 | 9,651 | ||||||
| Commitments and contingencies | ||||||||
| Stockholders’ equity: | ||||||||
| Preferred stock, | — | — | ||||||
| Common stock, | 64 | 46 | ||||||
| Additional paid-in capital | 447,686 | 434,474 | ||||||
| Accumulated deficit | (406,443 | ) | (385,144 | ) | ||||
| Total stockholders’ equity | 41,307 | 49,376 | ||||||
| Total liabilities and stockholders’ equity | $ | 77,626 | $ | 59,027 | ||||
SCYNEXIS, INC.
UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
(in thousands, except share and per share data)
| Three Months Ended March 31, | ||||||||
| 2026 | 2025 | |||||||
| License agreement revenue | $ | — | $ | 257 | ||||
| Operating expenses: | ||||||||
| Research and development | 12,351 | 5,141 | ||||||
| Selling, general and administrative | 4,588 | 3,726 | ||||||
| Total operating expenses | 16,939 | 8,867 | ||||||
| Loss from operations | (16,939 | ) | (8,610 | ) | ||||
| Other (income) expense: | ||||||||
| Amortization of debt issuance costs and discount | — | 312 | ||||||
| Interest income | (535 | ) | (776 | ) | ||||
| Interest expense | — | 173 | ||||||
| Other income | (354 | ) | — | |||||
| Warrant liability fair value adjustment | 5,249 | (2,928 | ) | |||||
| Total other expense (income) | 4,360 | (3,219 | ) | |||||
| Net loss | $ | (21,299 | ) | $ | (5,391 | ) | ||
| Net loss per share – basic and diluted | $ | (0.42 | ) | $ | (0.11 | ) | ||
| Weighted average common shares outstanding – basic and diluted | 50,957,191 | 49,435,500 | ||||||
CONTACT:
Investor Relations
John Fraunces
LifeSci Advisors
Tel: 917-355-2395
jfraunces@lifesciadvisors.com
