SHUTTLE PHARMACTCLS HLDGS INC Stock Price, News & Analysis

Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH) announced a research agreement with Georgetown University to evaluate its lead HDAC6 inhibitor candidate, SP-2-225. The collaboration will focus on the anti-tumor effects of SP-2-225 in combination with radiation therapy (RT) using a breast cancer model. The research aims to support IND-enabling studies in 2023 with plans for a Phase I clinical trial in 2024. SHPH's pipeline includes Ropidoxuridine, aimed at enhancing cancer cell sensitivity to RT, which is progressing towards Phase II testing in brain cancer patients. This partnership underscores SHPH's commitment to improving cancer treatment outcomes.

Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH) reported a corporate update on March 15, 2023, in conjunction with its Annual Report on Form 10-K for the fiscal year ending December 31, 2022. The company raised $11.5 million through its IPO and $4.3 million through a private placement. It is preparing for a Phase II clinical trial of its lead drug candidate, Ropidoxuridine, aimed at enhancing outcomes for glioblastoma patients undergoing radiation therapy. With a cash balance of $8.4 million as of December 31, 2022, and recent funding, Shuttle anticipates sufficient capital to support operations through Q4 2025.

Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH) announced a partnership with the University of Iowa Pharmaceuticals for the formulation development and clinical batch manufacturing of Ropidoxuridine. This step is crucial for their upcoming Phase II clinical trial aimed at glioblastoma treatment, expected to be submitted to the FDA by Q2 2023. The company has manufactured approximately 10,000 capsules for the trial, working alongside TCG GreenChem, Inc. With over 800,000 patients annually receiving radiation therapy in the U.S., Shuttle's focus on radiation sensitizers positions it to address significant market needs in oncology.

Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH) announced that it will lease new laboratory and office space in Gaithersburg, Maryland, starting in June 2023. This expansion aims to support the development of its lead drug candidate, Ropidoxuridine, which is designed to sensitize cancer cells during radiation therapy. The company is advancing a Phase II clinical trial for brain cancer patients and plans to submit an Investigational New Drug application to the FDA by Q2 2023. Shuttle's platform seeks to address clinical needs for radiation sensitizers and has received NIH funding for related research.

Shuttle Pharmaceuticals Holdings, Inc. (NASDAQ: SHPH), a pharmaceutical company dedicated to enhancing cancer treatment outcomes, announced that CEO Anatoly Dritschilo will present at the Lytham Partners Investor Select Conference on January 31, 2023. This virtual event will include one-on-one meetings with investors, providing a platform for discussion on the company's mission to improve radiation therapy efficacy while minimizing side effects. A webcast of the presentation will be available at 9:00 AM ET on the same day, with a replay option afterward. For more details, visit their website.

Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH) announced that its Chairman and CEO, Anatoly Dritschilo, will ring the Nasdaq opening bell on January 18, 2023. This event marks the company's recent IPO and highlights its commitment to developing therapies aimed at improving cancer treatment outcomes through radiation therapy. Dritschilo expressed excitement about their lead product candidate and the company's mission to enhance the effectiveness of radiation therapy while reducing side effects, aiming to benefit thousands of patients currently lacking effective treatment options.

Shuttle Pharmaceuticals Holdings, Inc. (NASDAQ: SHPH) announced a private placement of a $4.3 million senior secured convertible note and warrant. The company will receive $4.0 million initially, with a potential for an additional $2.4 million if warrants are exercised at $2.35 per share. Monthly amortizations can be settled in cash or stock and the deal has a 5% annual interest rate.

This initiative aims to support Shuttle's mission to enhance cancer treatment outcomes while minimizing radiation side effects.

Shuttle Pharmaceuticals Holdings (Nasdaq: SHPH) announced the publication of a manuscript that discusses immune responses in cancer patients post-radiation therapy. The study, authored by Dr. Amrita K Cheema, reveals how radiation therapy induces innate immune responses in patients with prostate cancer. Key findings include an increase in DNA Damage Response (DDR) shortly after treatment, and sustained immune signaling for up to three months. The research may inform the development of biomarkers and therapeutic strategies for better cancer treatment outcomes. The publication is available in Clinical Cancer Research.