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Silo Pharma Advances Intellectual Property Portfolio with Provisional Patent Filing for PTSD Treatment

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Silo Pharma (NASDAQ: SILO) has filed a provisional patent application with the USPTO for its lead asset SPC-15, targeting treatments for stress-induced psychiatric disorders, including PTSD. The patent covers the chronic, combinatorial targeting of N-methyl-D-aspartate receptors (NMDARs) and serotonin type IV receptors (5-HT4Rs) to extend behavioral effects against stress-induced perseverative behavior and hyponeophagia.

This filing enhances Silo's intellectual property portfolio for SPC-15 technology, which was originally licensed through a collaboration with Columbia University. The exclusive agreement grants Silo global rights to develop, manufacture, and commercialize SPC-15.

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  • Filed new provisional patent application for PTSD treatment technology
  • Holds exclusive global rights for SPC-15 development and commercialization through Columbia University agreement

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The filing of a provisional patent application for SPC-15 marks a important step in Silo Pharma's IP strategy, particularly given the company's modest $8.8M market capitalization. A provisional patent provides 12 months of protection while allowing the company to refine its claims before submitting a full patent application, effectively extending the potential protection period.

The dual-targeting mechanism of SPC-15, focusing on both NMDARs and 5-HT4Rs, represents a novel approach in the PTSD treatment landscape. This combinatorial strategy could potentially offer improved efficacy compared to single-target treatments, addressing both the immediate stress response and longer-term behavioral modifications.

The exclusive global rights secured through the Columbia University collaboration significantly enhance Silo's competitive position. This partnership with a prestigious research institution not only provides technological validation but also offers potential access to additional research resources and expertise. However, investors should note that the path from provisional patent to commercialization typically requires substantial capital investment and successful clinical trials.

For a micro-cap biotech company like Silo, building a robust IP portfolio is essential for creating shareholder value and attracting potential strategic partnerships or licensing agreements. The provisional patent filing, while promising, represents an early stage in the drug development process, with significant clinical and regulatory milestones still ahead.

SARASOTA, FL, Jan. 22, 2025 (GLOBE NEWSWIRE) -- Silo Pharma, Inc. (Nasdaq: SILO) (“Silo” or the “Company”), a developmental stage biopharmaceutical company focused on novel therapeutics and drug delivery systems, today announced the filing of a provisional patent application with the U.S. Patent and Trademark Office (USPTO). This application, focused on its lead asset SPC-15, highlights Silo’s commitment to advancing treatments for stress-induced psychiatric disorders, including post-traumatic stress disorder (PTSD).

The provisional patent covers the chronic, combinatorial targeting of N-methyl-D-aspartate receptors (NMDARs) and serotonin type IV receptors (5-HT4Rs) to extend behavioral effects against stress-induced perseverative behavior and hyponeophagia. This filing adds to Silo’s growing portfolio of pending patents for SPC-15 technology, originally licensed through a collaboration with Columbia University. This exclusive agreement enables Silo to develop, manufacture, and commercialize SPC-15 globally.

“Silo Pharma’s intellectual property strategy continues to be a cornerstone of our growth,” said Eric Weisblum, CEO of Silo Pharma. “We believe this latest provisional patent application reinforces our strong IP protection for SPC-15 and further positions us to deliver innovative therapies for patients with PTSD and other stress-induced disorders.”

About SPC-15
SPC-15 is an intranasal serotonin 5-HT4 receptor agonist aimed at treating stress-induced psychiatric disorders such as PTSD and anxiety. With its potential eligibility for the FDA’s streamlined 505(b)(2) regulatory pathway, SPC-15 offers a promising approach to accelerate the approval process. Silo Pharma is collaborating with Columbia University to conduct preclinical studies and has exclusive global rights to the development and commercialization of SPC-15.

About Silo Pharma
Silo Pharma Inc. (Nasdaq: SILO) is a developmental stage biopharmaceutical company focused on addressing underserved conditions, including stress-induced psychiatric disorders, chronic pain, and central nervous system (CNS) diseases. The Company’s portfolio includes innovative programs such as SPC-15 for PTSD, SP-26 for fibromyalgia and chronic pain, and preclinical assets targeting Alzheimer’s disease and multiple sclerosis. Silo’s research is conducted in collaboration with leading universities and laboratories. silopharma.com

Forward-Looking Statements 
This news release contains "forward-looking statements" within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. These statements are identified using words “could”, “believe”, “anticipate”, “intend”, “estimate”, “expect”, “may”, “continue”, “predict”, “potential”, and similar expressions that are intended to identify forward-looking statements. Such statements involve known and unknown risks, uncertainties, and other factors that could cause the actual results of Silo Pharma, Inc. (“Silo” or “the Company”) to differ materially from the results expressed or implied by such statements, including changes to anticipated sources of revenues, future economic and competitive conditions, difficulties in developing the Company’s technology platforms, retaining and expanding the Company’s customer base, fluctuations in consumer spending on the Company’s products and other factors. Accordingly, although the Company believes that the expectations reflected in such forward-looking statements are reasonable, there can be no assurance that such expectations will prove to be correct. The Company disclaims any obligations to publicly update or release any revisions to the forward-looking information contained in this press release, whether as a result of new information, future events, or otherwise, after the date of this press release or to reflect the occurrence of unanticipated events except as required by law.

Contact

800-705-0120 
investors@silopharma.com


FAQ

What is the latest patent application filed by Silo Pharma (SILO) in January 2024?

Silo Pharma filed a provisional patent application with the USPTO for SPC-15, targeting treatments for stress-induced psychiatric disorders, including PTSD.

What medical conditions does Silo Pharma's SPC-15 target?

SPC-15 targets stress-induced psychiatric disorders, specifically PTSD, through the targeting of N-methyl-D-aspartate receptors (NMDARs) and serotonin type IV receptors (5-HT4Rs).

What is the relationship between Silo Pharma and Columbia University regarding SPC-15?

Silo Pharma has an exclusive license agreement with Columbia University that allows them to develop, manufacture, and commercialize SPC-15 globally.

What are the key components of Silo Pharma's new provisional patent for SPC-15?

The patent covers the chronic, combinatorial targeting of NMDARs and 5-HT4Rs to extend behavioral effects against stress-induced perseverative behavior and hyponeophagia.
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Biotechnology
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SARASOTA