Solid Bioscience Stock Price, News & Analysis

Solid Biosciences (SLDB) reported significant progress in its Duchenne muscular dystrophy (Duchenne) therapies during Q3 2021. They announced plans to dose more patients with SGT-001 in the IGNITE DMD trial starting Q4 2021. Financially, the company ended Q3 with approximately $229.8 million in cash, ensuring a runway into Q2 2023. Collaboration revenue rose to $3.5 million, compared to none last year, while R&D expenses decreased to $14.4 million. The net loss narrowed to $18 million from $21.2 million in 2020, indicating improved fiscal management.

The Pathway Development Consortium (PDC), initiated by REGENXBIO and Solid Biosciences, released a draft white paper outlining a framework for the accelerated approval of AAV gene therapies. This initiative aims to unite stakeholders to expedite the development of effective treatments for rare diseases. The publication coincides with the PDC's formal launch, emphasizing collaboration among patients, regulators, and industry for meaningful discussions. Feedback is encouraged to refine this framework to support FDA approval of AAV gene therapies.

Solid Biosciences Inc. (Nasdaq: SLDB) announced its participation in the Jefferies Gene Therapy/Editing Summit on October 28, 2021, at 2:00 p.m. ET. Co-Founder and CEO Ilan Ganot, along with Chief Scientific Officer Carl Morris, will engage in a fireside chat. Investors can access a live webcast on the company’s investor relations website, with a replay available afterward. The company focuses on developing therapies for Duchenne muscular dystrophy, particularly through its gene therapy candidate, SGT-001.

Solid Biosciences (NASDAQ: SLDB) has partnered with Forge Biologics to enhance the development and manufacturing of SGT-003, a next-generation gene therapy aimed at Duchenne muscular dystrophy. The collaboration will leverage Forge's Blaze Vector™ production platform, focusing on AAV vector process and cGMP manufacturing at Forge's facility in Columbus, Ohio. This partnership is expected to accelerate clinical development and improve the production process, potentially offering new treatment avenues for patients suffering from Duchenne.

Solid Biosciences (Nasdaq: SLDB) has reported positive results from its ongoing IGNITE DMD Phase I/II clinical trial of SGT-001, aimed at treating Duchenne muscular dystrophy. Data presented at the Child Neurology Society 50th Annual Meeting indicated improvements in pulmonary function in patients receiving SGT-001 compared to untreated controls. Specifically, patients showcased significant percentage increases in peak expiratory flow and forced expiratory volume one year post-administration. These findings suggest the potential clinical benefit of SGT-001 in enhancing patient outcomes.

Solid Biosciences (Nasdaq: SLDB) reports positive findings from the ongoing IGNITE DMD Phase I/II trial of SGT-001, a gene therapy for Duchenne muscular dystrophy. The data, presented at the World Muscle Society 2021 Virtual Congress, shows sustained functional benefits and patient-reported outcomes 1.5 years post-treatment. Key metrics include a mean decrease of 1.7 points in North Star Ambulatory Assessment (NSAA) compared to a projected decline of 4.5 points, and a 15.3-meter increase in the 6-Minute Walk Test (6MWT). No new safety concerns were reported over 3.5 years.

Solid Biosciences Inc. (Nasdaq: SLDB) announced the upcoming presentation of long-term data from patients 4-6 in the IGNITE DMD Phase I/II clinical trial of SGT-001 for Duchenne muscular dystrophy. The data will be presented by Dr. Vamshi Rao at the World Muscle Society 2021 Virtual Congress on September 23, 2021. SGT-001 aims to address the genetic cause of Duchenne by delivering a synthetic dystrophin gene via an adeno-associated viral vector. The therapy has received multiple designations from regulatory authorities, reflecting its potential in treating Duchenne.

Solid Biosciences (Nasdaq: SLDB) announces participation of Dr. Joel Schneider and Dr. Carl Morris at the SVB Leerink CybeRx Series and Chardan's 5th Annual Genetic Medicines Conference. The fireside chat from the Chardan conference will be available via live webcast on October 5, 2021, at 2:30 p.m. ET on the company's investor relations website. Solid Biosciences is committed to developing transformative therapies for Duchenne muscular dystrophy and is advancing its lead gene therapy candidate, SGT-001.

Solid Biosciences (Nasdaq: SLDB) will showcase its advanced AAV gene therapy manufacturing capabilities at the 11th Annual World Orphan Drug Congress USA 2021 on August 27 at 11:15 AM ET. Chief Operating Officer Joel Schneider, PhD, will discuss the scalable approach to producing AAV gene therapies targeting Duchenne muscular dystrophy (Duchenne). Following his talk, he will join a panel discussion on manufacturing strategies at 11:55 AM ET. Solid’s gene therapy candidate, SGT-001, aims to address the genetic cause of Duchenne and has received several designations to expedite development.