Silence Therapeutics plc develops siRNA therapies through its proprietary mRNAi GOLD platform and trades in the U.S. through American Depositary Shares under SLN. Company news commonly covers clinical and preclinical updates for RNA-silencing programs in cardiovascular disease, hematology and rare diseases, along with financial results, research presentations and collaboration activity.
Recurring pipeline coverage centers on divesiran, a wholly owned siRNA candidate targeting TMPRSS6 for polycythemia vera, including SANRECO study updates and its FDA Fast Track and Orphan Drug designations. Updates also address platform-derived programs such as SLN312, AstraZeneca collaboration matters, balance-sheet commentary and board or executive changes.
On December 1, 2021, Silence Therapeutics plc (Nasdaq: SLN) announced a significant investment from Deep Track Capital, totaling approximately $22 million in American Depositary Shares from existing shareholders. This investment is seen as a vote of confidence in Silence's promising pipeline, particularly its proprietary mRNAi GOLD™ platform. The company anticipates key data from its SLN360 program in early 2022, aiming to address cardiovascular risks associated with high lipoprotein(a). This marks Silence's first day of exclusive trading on Nasdaq and a continued expansion of its U.S. institutional shareholder base.
Silence Therapeutics, a leader in RNA interference therapeutics, has successfully transitioned its trading from AIM to the Nasdaq Global Market under the ticker symbol SLN as of November 30, 2021. This move aims to enhance investor access, particularly targeting U.S. institutional funds. The last trading day on AIM was November 29, 2021, and the company encourages shareholders to convert their Ordinary Shares into American Depositary Shares (ADSs) for Nasdaq trading. Silence continues to advance its mRNAi GOLD™ platform with ongoing collaborations and product candidates addressing significant medical needs.
Silence Therapeutics will present at the Jefferies London Healthcare Conference from November 16-18, 2021. The on-demand presentation will be available starting November 18 at 8:00am GMT / 3:00am ET via the company's website. Silence Therapeutics focuses on developing siRNA therapeutics targeting diseases with significant unmet medical needs. Their proprietary mRNAi GOLD™ platform aims to treat conditions like high lipoprotein(a) levels and iron-loading anemia. Archived webcasts will also be accessible post-conference.
Silence Therapeutics plc (AIM: SLN, Nasdaq: SLN) announced that Frazier Life Sciences has acquired approximately $20 million worth of ordinary shares, becoming a 3% shareholder. This partnership underscores Silence’s potential in RNA interference technology and enhances its financial backing as it progresses with two clinical stage programs and expands its pre-clinical pipeline using its mRNAi GOLD™ platform. The move aligns with Silence's strategy to attract institutional investors, particularly after its delisting from AIM.
Silence Therapeutics (AIM:SLN, Nasdaq:SLN) announced updates on its mRNAi GOLD™ platform during its R&D Day on October 21, 2021. Key highlights include plans to initiate a Phase 1 study for polycythemia vera (PV) using SLN124, targeting a market of 3.5 million individuals. SLN360 is on track for topline data in Q1 2022, while the company aims to deliver 2-3 INDs annually from 2023. The FDA has accepted SLN124's IND for myelodysplastic syndrome (MDS), and ongoing studies in thalassemia are expected to yield topline results in Q3 2022.
Silence Therapeutics has announced plans to cancel the admission of its ordinary shares to trading on AIM and transition the primary trading venue to Nasdaq. This AIM Delisting is set to take effect on 30 November 2021, with the last trading day on AIM being 29 November 2021. The company aims to enhance liquidity for its American Depositary Shares (ADSs) and streamline operations. A general meeting is scheduled for 1 November 2021 to seek shareholder approval. This significant change is expected to attract more US-based investors and reduce compliance costs.
Silence Therapeutics (AIM:SLN, Nasdaq: SLN) and Hansoh Pharma (3692.HK) have announced a collaboration to develop therapeutics using Silence’s mRNAi GOLD™ platform. Hansoh will make an upfront cash payment of $16 million, with Silence eligible for up to $1.3 billion in milestone payments. The partnership enables exclusive rights to two targets for Silence in regions excluding China, while Hansoh retains rights in China and global rights to a third target. Silence anticipates that this collaboration will advance its proprietary programs and provide access to the significant Chinese pharmaceutical market.
Silence Therapeutics plc (AIM: SLN, Nasdaq: SLN) will host its R&D Day on October 21, 2021, in New York City, featuring presentations on its mRNAi GOLD™ platform programs. This includes insights into lead clinical programs SLN360, targeting cardiovascular disease from high lipoprotein(a), and SLN124, aimed at treating thalassemia and myelodysplastic syndrome. The event will run from 9:00 a.m. to 11:30 a.m. EDT and will be available via a live webcast. Attendees must pre-register and provide proof of COVID-19 vaccination to enter.
Silence Therapeutics (AIM: SLN, Nasdaq: SLN) will participate in a fireside chat during the Chardan Virtual Genetic Medicines Conference on October 5 at 8:30 a.m. EDT. The event highlights the company's innovative siRNA therapeutics aimed at addressing diseases with significant unmet medical needs. A live webcast will be available on their website, and an archived replay will follow. Silence's ongoing projects include SLN360 for cardiovascular risk and SLN124 for iron-loading anemia.
Silence Therapeutics has appointed Dr. John Strafford as Senior Vice President of Business Development, Alliance Management, and New Product Development, effective immediately. Dr. Strafford, who has been with the company since 2018 and previously served as Vice President, will continue to advance business development efforts and lead the new product development function. His past collaborations with major firms like AstraZeneca have generated over $100 million in upfront payments, with total potential deal values exceeding $6 billion.