Welcome to our dedicated page for Summit Therapeutics news (Ticker: SMMT), a resource for investors and traders seeking the latest updates and insights on Summit Therapeutics stock.
Summit Therapeutics Inc. (NASDAQ: SMMT) is a biopharmaceutical oncology company whose news flow is closely tied to the development of its lead investigational therapy, ivonescimab (SMT112 in Summit’s territories). Ivonescimab is described by the company as a potential first-in-class bispecific antibody targeting PD-1 and VEGF in a single molecule, and it is being evaluated in multiple Phase III clinical trials in non-small cell lung cancer (NSCLC) and colorectal cancer (CRC).
News about Summit frequently covers clinical milestones for ivonescimab, including updates from the global Phase III HARMONi trial in EGFR-mutated NSCLC after third-generation EGFR TKI therapy, as well as HARMONi-3 and HARMONi-7 in first-line metastatic NSCLC and HARMONi-GI3 in first-line unresectable metastatic CRC. Company announcements have highlighted progression-free survival and overall survival data, hazard ratios, response rates, and safety profiles, along with presentations at major conferences such as the World Conference on Lung Cancer, SITC, and ESMO.
Investors following SMMT news will also see regulatory and corporate updates, including Summit’s submission of a Biologics License Application to the U.S. FDA for ivonescimab plus chemotherapy in EGFR-mutated NSCLC, Fast Track designation for the HARMONi setting, and summaries of Akeso’s HARMONi-A trial in China, which demonstrated a statistically significant overall survival benefit for ivonescimab plus chemotherapy versus chemotherapy alone.
Additional news items cover financing activities such as private placements and at-the-market offerings, inducement stock option grants under Nasdaq Listing Rule 5635(c)(4), and collaboration announcements. Notably, Summit has reported a clinical trial collaboration with GSK plc to evaluate ivonescimab in combination with GSK’s investigational B7-H3-targeting antibody-drug conjugate, risvutatug rezetecan (GSK’227), across multiple solid tumor settings including small cell lung cancer.
For readers tracking SMMT, the news stream provides insight into Summit’s late-stage oncology pipeline, regulatory interactions, capital-raising efforts, and partnerships that shape the company’s development path.
Summit Therapeutics (NASDAQ: SMMT) has announced inducement grants of stock options to nine new employees. The options collectively allow for the purchase of up to 94,050 shares of common stock at an exercise price of $22.75 per share, which was the closing price on May 14, 2025. The options have a ten-year term and will vest in equal annual installments over a four-year period. These grants were approved by Summit's Compensation Committee and were awarded in accordance with Nasdaq Listing Rule 5635(c)(4), which allows for inducement grants to new employees.
Summit Therapeutics (NASDAQ: SMMT) reports positive interim overall survival analysis results for ivonescimab from the HARMONi-2 Phase III trial in China. The study, conducted by Akeso, compared ivonescimab monotherapy to pembrolizumab in patients with PD-L1 positive advanced non-small cell lung cancer (NSCLC).
Key findings include:
- Overall survival hazard ratio of 0.777 favoring ivonescimab at 39% data maturity, suggesting a potential 22% reduction in death risk versus pembrolizumab
- Previously reported primary endpoint showed statistically significant improvement in progression-free survival with hazard ratio of 0.51 (p<0.0001)
- Chinese NMPA has approved ivonescimab for this second indication
Summit is currently conducting HARMONi-7, a global Phase III trial evaluating ivonescimab against pembrolizumab in similar patient population, with registrational intent for the US and other regions.
Summit Therapeutics (NASDAQ: SMMT) has announced it will release its first quarter 2025 financial results and provide an operational update after market close on Thursday, May 1, 2025. The company will host a live webcast earnings conference call at 4:30 PM ET on the same day. Investors and interested parties can access the webcast through the company's website at www.smmttx.com. A recorded version of the conference call will be made available on the website for those unable to attend the live session.
Summit Therapeutics (NASDAQ: SMMT) announced positive results from Akeso's Phase III HARMONi-6 clinical trial, where ivonescimab plus chemotherapy demonstrated statistically significant superiority in progression-free survival (PFS) compared to tislelizumab plus chemotherapy in first-line treatment of squamous non-small cell lung cancer (NSCLC).
The trial, conducted in China, showed meaningful PFS benefits across both PD-L1 positive and negative tumors, with no new safety concerns identified. This marks the first known Phase III trial showing significant improvement over PD-(L)1 inhibitor therapy combined with chemotherapy in NSCLC.
Following the success of HARMONi-2, this is the second instance where ivonescimab-based regimens have shown superior results versus standard-of-care PD-(L)1 inhibitor treatments. Summit is currently enrolling patients in HARMONi-3, a global Phase III trial comparing ivonescimab plus chemotherapy against pembrolizumab plus chemotherapy in first-line metastatic NSCLC.
Summit Therapeutics (NASDAQ: SMMT) has announced the granting of inducement stock options to ten new employees. The awards, approved by the Company's Compensation Committee, allow the purchase of up to 176,915 shares of common stock at an exercise price of $19.29 per share, matching the closing price on March 31, 2025.
The options, granted in accordance with Nasdaq Listing Rule 5635(c)(4), feature a ten-year term and will vest in equal annual installments over four years. These awards were drawn from an equity incentive pool established on January 22, 2025, specifically designated for new employee inducements.
Summit Therapeutics (NASDAQ: SMMT) has announced the granting of inducement stock options to seven new employees. The options allow for the purchase of up to 147,500 shares of common stock at an exercise price of $20.13 per share, which was the closing price on March 17, 2025.
The options, approved by Summit's Compensation Committee, have a ten-year term and will vest in equal annual installments over a four-year period. These awards were granted as inducement material under Nasdaq Listing Rule 5635(c)(4) and were drawn from an equity incentive pool established on January 22, 2025.
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