Welcome to our dedicated page for Sonnet Biotherapeutc Hldng news (Ticker: SONN), a resource for investors and traders seeking the latest updates and insights on Sonnet Biotherapeutc Hldng stock.
Sonnet BioTherapeutics Holdings Inc (NASDAQ: SONN) is a clinical-stage biotechnology innovator developing targeted immunotherapies through its proprietary FHAB platform. This page serves as the definitive source for verified company announcements, including clinical trial updates, regulatory milestones, and strategic developments in immuno-oncology.
Investors and researchers will find timely updates on SONN's pipeline progress, including its lead candidates targeting cancer and immune-mediated conditions. Our curated news collection features press releases about FHAB technology advancements, partnership announcements, and financial disclosures – all essential for tracking this innovative biotech's trajectory.
The repository systematically organizes updates across key categories: new patent filings, preclinical data publications, Phase 1 trial results, and executive team developments. Each entry maintains strict editorial standards to ensure compliance with financial reporting regulations.
For those monitoring advancements in bispecific antibody therapies and tumor microenvironment modulation, this resource offers structured access to SONN's scientific and corporate developments. Bookmark this page for efficient tracking of how the company's platform-based approach translates to clinical progress and strategic positioning within the competitive oncology landscape.
Sonnet BioTherapeutics (NASDAQ: SONN) has received a Notice of Allowance from the USPTO for a patent covering its modified version of Interleukin-18 (IL-18BPR). The patent specifically covers variant human IL-18 proteins with amino acid substitutions at positions Y1W, Y1K, M51Y, M51S, M60W, S105E, and D110Y.
The company's IL-18BPR demonstrates wild-type binding to the IL-18 receptor while showing undetectable binding to the inhibitory IL-18 Binding Protein, potentially making it more effective. This development strengthens Sonnet's intellectual property position and opens up licensing opportunities independent of their FHAB platform.
Sonnet has developed two drug candidates utilizing this technology: SON-1411, a bifunctional fusion protein combining IL-18BPR with IL-12, and SON-1400, a monofunctional fusion protein. Both are linked to Sonnet's Fully Human Albumin Binding (FHAB) platform, which extends half-life and targets the tumor microenvironment.
Sonnet BioTherapeutics Holdings (NASDAQ: SONN), a clinical-stage company focused on developing targeted immunotherapeutic drugs, has participated in the Virtual Investor 'Top 5 for '25' On-Demand Conference on March 11, 2025.
During the event, Founder and CEO Pankaj Mohan, Ph.D. presented the top five reasons why investors and industry colleagues should focus on Sonnet in 2025. The presentation is now available for viewing on-demand through the conference platform and on the Events page in the Investors section of Sonnet's website.
Sonnet BioTherapeutics (NASDAQ: SONN) presented data at the 2025 AACR:IO Conference showcasing their SON-1010 immunotherapy platform. The presentation highlighted their Fully Human Albumin Binding (FHAB®) technology, which enhances tumor targeting and extends the half-life of interleukin-12.
Key clinical findings revealed a 48% clinical benefit rate in advanced solid tumor patients, including a partial response at the highest dose in a clear cell sarcoma patient. The company is conducting multiple trials, including combinations with atezolizumab for platinum-resistant ovarian cancer and planned studies with NALIRIFOX for pancreatic cancer.
The FHAB platform addresses traditional cytokine therapy limitations by improving drug delivery to the tumor microenvironment (TME) and reducing toxicity risks. The technology demonstrates enhanced targeting through albumin binding to FcRn, GP60, and SPARC, resulting in increased activation of various immune cells and conversion of pro-tumor M2 MDSCs to inflammatory M1 APCs.
Sonnet BioTherapeutics (NASDAQ: SONN) announced the advancement of its proprietary Antibody Drug Conjugate (ADC) platform for drug discovery partnerships. The platform leverages the company's FHAB targeting domain and flexible docking peptides, offering controllable drug-antibody ratios (DAR).
Their initial proof-of-concept construct, SON-5010, demonstrated comparable performance to Kadcyla® and trastuzumab-MMAE in preclinical studies. SON-5010 comprises an anti-HER2-FHAB-anti-HER2 targeting scaffold linked to MMAE, showing similar tumor reduction activity at 10mg/kg in the BT-474 HER2+ carcinoma breast tumor mouse model.
The platform's key advantages include stable structural integrity, extended conjugation site flexibility, potential for enhanced tumor penetration, and the ability to select various payloads with different mechanisms of action for targeting cancer cells.
Sonnet BioTherapeutics (NASDAQ: SONN) announced that its abstract has been accepted for poster presentation at the 2025 American Association for Cancer Research (AACR) IO Conference. The conference will be held from February 23-26, 2025, at the JW Marriott in Los Angeles.
The presentation, scheduled for Tuesday, February 25, 2025 (1:45-4:45 PM PT), will focus on combination immunotherapy with an albumin-binding interleukin-12 fusion protein. The research explores how this protein extends cytokine half-life, targets the tumor microenvironment, and enhances therapeutic efficacy.
Sonnet BioTherapeutics (NASDAQ:SONN) has appointed Stephen J. McAndrew, Ph.D., as Chief Business Officer, effective February 17, 2025. Dr. McAndrew, who brings over 30 years of experience in biologics transactions, has been serving as Vice President and Senior Vice President of Business Development at Sonnet, managing partnering strategy, research partnerships, and the global IP portfolio.
The appointment aims to strengthen Sonnet's business development initiatives as their FHAB assets advance in clinical development. Dr. McAndrew's extensive experience includes senior roles at Oncobiologics (now Outlook Therapeutics) and Bristol-Myers Squibb, where he managed business development, licensing, and marketing functions.
Sonnet BioTherapeutics (NASDAQ: SONN) has reported key developments in its clinical programs and financial results for Q1 FY2025. The company completed the Phase 1 SB101 trial dose escalation for SON-1010, showing stable disease in 48% of evaluable monotherapy patients and one partial response with 45% tumor reduction. Clinical trials are progressing for SON-1010 combinations with Atezolizumab and trabectedin.
The company secured a licensing agreement with Alkem Laboratories for SON-080 in India and reported Q1 FY2025 financial results with a net loss of $3.2 million ($1.56 per share), compared to $1.2 million loss in Q1 FY2024. Cash position stands at $4.9 million as of December 31, 2024. The company recently raised $3.9 million through a registered direct offering.
Leadership changes include Stephen McAndrew's promotion to Chief Business Officer and Donald Griffith's appointment as new CFO, replacing Jay Cross.
Sonnet BioTherapeutics (NASDAQ: SONN) has secured European Patent No. EP3583125 B1 for its Fully Human Albumin Binding (FHAB®) technology, effective until February 20, 2038. The patent covers therapeutic fusion proteins utilizing FHAB for tumor targeting and extended pharmacokinetics.
The company's FHAB platform consists of a single, fully human construct with high affinity to bind to human albumin, providing an off-the-shelf solution for rapid therapeutic biologics development. This EU patent adds to Sonnet's existing global IP protection in China, Japan, Russia, and New Zealand.
Preclinical studies have demonstrated that FHAB-derived drug candidates show extended pharmacokinetics, enhanced tumor payload delivery, and improved efficacy compared to wild type cytokines. The platform enables both mono- and bi-functional mechanisms of action, potentially allowing for biological synergy between cytokines.
Sonnet BioTherapeutics (NASDAQ: SONN), a clinical-stage company focused on developing targeted immunotherapeutic drugs, has announced its participation in an upcoming healthcare investment webinar. Dr. Pankaj Mohan, the company's CEO, will present at the LIVE! with Webull Corporate Connect: Healthcare Investment Webinar on Wednesday, January 29th, 2025 at 2:40 PM ET.
The virtual biotech investment event provides an opportunity for investors to learn more about Sonnet's developments in the immunotherapeutics space. Interested participants can access the presentation through the provided registration link.
Sonnet BioTherapeutics (NASDAQ:SONN) announced the expansion of its Phase 1 SB101 clinical study of SON-1010 to evaluate its combination with trabectedin in soft-tissue sarcoma patients. The expansion follows successful monotherapy dose escalation and will explore SON-1010's immune-oncology impact at the maximum tolerated dose of 1200 ng/kg.
The study will enroll up to 18 patients with unresectable, metastatic liposarcoma or leiomyosarcoma. Enrollment is expected to complete in H1 2025, with topline safety data anticipated in H2 2025. The trial's primary outcomes include safety, tolerability, pharmacokinetics, and pharmacodynamics of SON-1010.
SON-1010, Sonnet's proprietary version of IL-12, is configured using the FHAB platform to extend half-life and bioactivity. The company believes combining SON-1010 with trabectedin could enhance local immune response in the tumor microenvironment and potentially improve treatment outcomes for soft-tissue sarcoma patients.
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