Sonnet BioTherapeutics Holdings Inc. develops immunotherapeutic biologic drugs for oncology using its FHAB Fully Human Albumin-Binding platform. The platform uses a fully human single-chain antibody fragment designed to bind human serum albumin and transport large-molecule therapies toward tumor and lymphatic tissue, supporting constructs that include cytokines, peptides, antibodies and vaccines.
Company news centers on clinical and regulatory updates for targeted oncology programs, including SON-1010 or IL-12-FHAB in solid tumors and platinum-resistant ovarian cancer, as well as scientific conference presentations, shareholder voting matters, financing activity, capital-structure disclosures and governance developments.
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Sonnet BioTherapeutics Holdings (NASDAQ:SONN) reported progress in its Phase 1 clinical trials for SON-1010, an immunotherapeutic drug. The company is enrolling the final dose cohort for the cancer trial (SB101) which has dosed 15 patients, with 36% showing clinical benefit based on stable disease results. No dose-limiting toxicities were observed, and adverse events were mostly mild and transient. SON-1010 demonstrated a prolonged half-life, with pharmacokinetic data suggesting effective targeting of tumors. The next steps include investigating SON-1010's impact on platinum-resistant ovarian cancer. Sonnet's current financial position allows for operational activities into 2024. A webinar discussing these results is scheduled for today at 5 pm ET.
Sonnet BioTherapeutics Holdings (NASDAQ:SONN), a clinical-stage biopharmaceutical firm, announced a webcast on April 18, 2023, at 5:00 pm ET to present data from its SB101 study with SON-1010 involving oncology patients (NCT05352750). Presenters include Richard Kenney, M.D. and Pankaj Mohan, Ph.D.. The webcast will offer a detailed overview of the clinical trial and will be available for later access on the company's website. Also, a poster presentation titled Clinical development of a novel form of interleukin-12 will occur during the AACR 2023 Annual Meeting on April 18, from 1:30 pm to 5:00 pm ET. Sonnet's FHB technology aims to enhance the efficacy of immunotherapeutic drugs by targeting tumor tissues effectively, which is essential for its ongoing clinical applications.
Sonnet BioTherapeutics Holdings (NASDAQ:SONN) announced it will present data from the SB101 multiple-dose clinical trial of SON-1010 (IL12-FHAB) at the AACR Annual Meeting 2023 in Orlando, Florida, from April 14-19. The presentation, titled "Clinical development of a novel form of interleukin-12 with extended pharmacokinetics," is scheduled for April 18, 2023, from 1:30 PM to 5:00 PM. SON-1010 is designed for treating adult patients with advanced solid tumors and utilizes FHAB technology for improved targeting of tumor and lymphatic tissues. This marks a significant step in Sonnet's commitment to advancing oncology treatments.