Spero Therapeuti Stock Price, News & Analysis

Spero Therapeutics (Nasdaq: SPRO) reported its Q1 2022 financial results, revealing a net loss of $32.8 million, up from $19.4 million in Q1 2021. Total revenues plummeted to $2.1 million from $7.3 million due to decreased funding under previous contracts. The company announced plans to initiate a Phase 2 trial for SPR720 in Nontuberculous Mycobacterial-Pulmonary Disease in H2 2022, while SPR206 shows promise for treating multi-drug resistant infections. With a cash position of $122 million, Spero aims to sustain its operations through late 2023 amid a strategic focus on clinical milestones.

Spero Therapeutics (Nasdaq: SPRO) will have Ankit Mahadevia, M.D., its CEO, presenting at two upcoming conferences: the 2022 RBC Capital Markets Global Healthcare Conference on May 18, 2022, and the H.C. Wainwright Global Investment Conference on May 25, 2022. The RBC presentation will feature a fireside chat format at 3:35 PM ET, while the H.C. Wainwright presentation will occur at 12:30 PM ET. Webcasts can be accessed via Spero Therapeutics' website, where replays will also be available.

Spero focuses on treating multi-drug resistant bacterial infections and rare diseases.

Spero Therapeutics (Nasdaq: SPRO) will host a conference call on May 16, 2022, at 4:30 p.m. ET to discuss its Q1 2022 financial results and update on its business and pipeline. The conference call is accessible at 1-877-704-4453 (domestic) or 1-201-389-0920 (international) using conference ID 13729221. Additionally, an audio webcast will be available on its website, which will be archived for 30 days. Spero focuses on developing treatments for complicated bacterial infections, with the FDA reviewing its New Drug Application for tebipenem HBr.

Spero Therapeutics (NASDAQ: SPRO) announced the immediate cessation of commercialization activities for tebibenen HBr due to FDA feedback indicating insufficient data for approval. The company will reduce its workforce by about 75% and shift focus to the development of new drugs SPR720 and SPR206. While anticipating cost savings to fund operations through late 2023, Spero remains committed to engaging with the FDA for the potential approval of tebipenem HBr. The company ended the previous year with approximately $146.4 million in cash.

Spero Therapeutics, Inc. (Nasdaq: SPRO) announced its participation in the 32nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) from April 23-26, 2022, in Lisbon, Portugal. The company will present two oral presentations and four posters focused on its investigational antibiotic candidate, tebipenem HBr. Notably, one of the posters has been recognized as a top-rated presentation. Tebipenem HBr is currently under FDA review and aims to treat complicated urinary tract infections.

Spero Therapeutics (Nasdaq: SPRO) announced the publication of the Phase 3 ADAPT-PO clinical trial results for tebipenem pivoxil hydrobromide in The New England Journal of Medicine. This trial is the first head-to-head comparison of oral versus intravenous treatments for complicated urinary tract infections. The NDA for tebipenem HBr is currently under FDA review with a PDUFA target date of June 27, 2022. The drug aims to provide an oral treatment option for adult patients with limited options.

Spero Therapeutics (Nasdaq: SPRO) provided updates on its clinical programs and financial performance for Q4 and full-year 2021. The FDA identified deficiencies in the NDA review for tebipenem HBr, impacting labeling discussions, but a meeting is scheduled to address these issues. Spero expects a commercial launch of tebipenem HBr in 2H 2022, pending approval. The company reported a net loss of $89.8 million for 2021, with total revenue rising to $18.3 million. Ongoing trials for SPR720 and SPR206 show potential for future development and value creation.

Spero Therapeutics (Nasdaq: SPRO) will hold a conference call on March 31, 2022, at 4:30 p.m. ET to discuss its fourth quarter and full-year 2021 financial results and provide a business update. The call can be accessed via phone or a live audio webcast available on Spero's website. Spero focuses on creating novel treatments for multi-drug-resistant bacterial infections, with its lead candidate, tebipenem HBr, recently receiving FDA NDA acceptance. This investigational drug aims to address complicated urinary tract infections but is not yet approved.

Spero Therapeutics announced positive results from its Phase 1 bronchoalveolar lavage (BAL) clinical trial for SPR206, its next-generation polymyxin candidate, which targets drug-resistant gram-negative infections. With a well-tolerated profile, the drug showed a lung epithelial lining fluid to plasma concentration ratio of 0.264, ensuring effective dosing against targeted pathogens. The findings support advancement into further clinical trials for hospital-acquired and ventilator-associated pneumonia. SPR206 has the potential to address critical treatment gaps for patients with serious bacterial lung infections.