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SQZ Biotechnologies (NYSE: SQZ) presented promising preclinical data on tumor infiltrating lymphocytes (TILs) at the ESMO Congress 2022. Engineered with membrane-bound cytokines IL-2 and IL-12, these TILs may eliminate the need for toxic preconditioning and IL-2 administration. Key findings include enhanced TIL proliferation, tumor cell killing, and markers associated with T cell memory. The data indicates potential for outpatient TIL therapy, enabling repeat dosing and combination treatments. This advancement could redefine current TIL therapies.
SQZ Biotechnologies (NYSE: SQZ) announced that Armon Sharei, Ph.D., CEO and Founder, will present at two upcoming conferences: the H.C. Wainwright 24th Annual Global Investment Conference on September 14 and the Chardan 6th Annual Genetic Medicines Conference on October 4. Both events will be held in New York, NY. Presentation times are set for 11:00-11:30 a.m. ET on September 14 and 1:30-2:00 p.m. ET on October 4. Webcast details are available on the SQZ website, along with a corporate overview.
SQZ Biotechnologies announces the appointment of Howard Bernstein, M.D., Ph.D., as a member of its Board of Directors, effective October 31, 2022. Dr. Bernstein has been with the company as Chief Scientific Officer since July 2015 and will continue to offer operational consultation during the transition. Ipsita Roymoulik, Ph.D., Scott Loughhead, Ph.D., and Maisam Dadgar will now share CSO responsibilities. The company focuses on advancing cell therapies for cancer and autoimmune diseases, leveraging its proprietary Cell Squeeze® technology.
SQZ Biotechnologies, focused on cell therapies, reported Q2 2022 results with revenue at $3.2 million, down from $4.5 million year-over-year. The company received FDA Fast Track Designation for its APC candidate targeting HPV16+ tumors and showcased advancements in its Point-of-Care manufacturing system. R&D expenses rose to $18.8 million from $17.7 million, and net loss increased to $22.2 million. Cash reserves of $105.6 million are expected to support operations until late 2023.
SQZ Biotechnologies has published a technical review in ESMO's Immuno-Oncology and Technology journal focusing on the effectiveness of SQZ Antigen Presenting Cells (APCs) in activating CD8 T cells via MHC-I antigen presentation. The company underlined its proprietary Cell Squeeze® technology as superior for cell engineering and manufacturing. The review discusses the ongoing SQZ-PBMC-HPV-101 clinical trial which aims to improve CD8 T cell infiltration in solid tumors, with early indicators of clinical benefits observed. Future expansions into additional cancer areas were highlighted.
SQZ Biotechnologies announced the elevation of Micah Zajic to Chief Financial Officer, effective July 11, 2022. Previously serving as Chief Business Officer since October 2020, Zajic brings nearly 20 years of experience in biotechnology and capital markets. He will oversee finance, accounting, business development, investor relations, and communications. CEO Armon Sharei praised Zajic's contributions to the executive team. SQZ aims to enhance its cell therapy capabilities, leveraging proprietary technology to improve patient access and treatment outcomes.
SQZ Biotechnologies presented new findings on its Tolerizing Antigen Carrier (TAC) platform at the FOCIS annual meeting, showing the ability of SQZ TACs to present antigens associated with celiac disease to T cells, potentially supporting treatment strategies. The Cell Squeeze process enables consistent production of TACs with high antigen levels, building on previous research related to type 1 diabetes. The company plans to submit an Investigational New Drug application for celiac disease in the first half of 2023, marking significant progress in its therapeutic development.
SQZ Biotechnologies (NYSE: SQZ) presented promising preclinical research demonstrating its Cell Squeeze® technology's ability to generate dopaminergic neurons from human-induced pluripotent stem cells (iPSCs). This was achieved through the delivery of six RNA transcription factors, enhancing gene expression significantly—by up to 25,000-fold for the FOXA2 gene within four days. The findings are part of the company's NIH-funded program aimed at developing scalable therapies for Parkinson's disease. The results were showcased at the 2022 ISSCR annual meeting, indicating a step forward in regenerative medicine.
SQZ Biotechnologies (NYSE: SQZ) has announced that CEO Armon Sharei will present at the Jefferies Healthcare Conference on June 8 in New York, scheduled from 2:30-2:55 p.m. ET. The presentation will be available via webcast. SQZ Biotechnologies focuses on advancing cell therapies across oncology, autoimmune, and infectious diseases, using its proprietary Cell Squeeze® technology for rapid production. More details can be found on their website.
SQZ Biotechnologies has appointed Dr. Marshelle Smith Warren as Chief Medical Officer, effective June 1, 2022. With over 25 years of experience in clinical development, Dr. Warren specializes in cell-based therapeutics, particularly in oncology and immunology. She previously held leadership roles in notable firms such as Viracta Therapeutics and Gilead Sciences. CEO Armon Sharei emphasized her expertise would enhance the company's clinical programs. SQZ focuses on innovative cell therapies targeting diseases like Human Papillomavirus-positive solid tumors and celiac disease.