Theravance Biopharma, Inc. Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Corporate Update
Rhea-AI Summary
Theravance Biopharma (NASDAQ: TBPH) reported Q4 and full-year 2025 results and a corporate update on March 19, 2026. Key points: YUPELRI FY net sales $266.6M (+12% YoY) triggered a $25M milestone; TRELEGY FY net sales ~$3.9B (+13% YoY) triggered $50M. Company ended Q4 with $326.5M cash and expects ~ $400M at 3/31/2026; no debt. Following Phase 3 CYPRESS results, Theravance is winding down R&D, cutting operating expenses ~60% and targeting $60–$70M of annualized cash flow starting Q3 2026. A Board Strategic Review Committee is accelerating evaluation of value-maximizing alternatives, including a possible sale.
Positive
- YUPELRI net sales $266.6M in 2025 (+12% YoY)
- TRELEGY-linked milestone $50M recognized in Q4 2025
- Expected cash of approximately $400M at end of Q1 2026; no debt
- Planned opex reduction ~60% targeting $60–$70M annualized cash flow from Q3 2026
Negative
- R&D wind-down underway with near-complete R&D closure by Q3 2026
- Workforce reduction expected to impact ~50% of employees
- Material dependence on milestones for near-term cash (YUPELRI/TRELEGY payments)
- Strategic review uncertainty — Committee may pursue sale; outcome not assured
News Market Reaction – TBPH
In the Mar 19 session, TBPH gained 1.30%, reflecting a mild positive market reaction.
Data tracked by StockTitan Argus on the day of publication.
Key Figures
Previous Earnings Reports
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Nov 10 | Q3 2025 earnings | Positive | +22.7% | Record YUPELRI sales, non-GAAP breakeven, strong cash, TRELEGY milestones on track. |
| Nov 10 | Q3 2025 earnings | Positive | +22.7% | Repeat Q3 report highlighting YUPELRI growth, cash strength, and CYPRESS progress. |
| Aug 12 | Q2 2025 earnings | Positive | +4.2% | Strong YUPELRI growth, TRELEGY royalty sale for $225M, solid revenue and income. |
| May 08 | Q1 2025 earnings | Neutral | -9.3% | Strong product growth but net loss; investors reacted modestly negatively to mix. |
| Feb 26 | FY 2024 earnings | Positive | +2.1% | Record 2024 results, YUPELRI growth, TRELEGY milestone, and clear 2025 guidance. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Earnings releases have often coincided with positive price reactions, especially when YUPELRI growth, cash strength, and TRELEGY milestones were highlighted.
Over the last year, Theravance’s earnings updates have emphasized expanding YUPELRI net sales, growing TRELEGY-linked milestones, and a strengthening cash position with no debt. Q1–Q3 2025 results showed rising YUPELRI revenue, record quarterly sales like $71.4M, and cash balances above $130M, later exceeding $330M. The February 2025 FY2024 report also underscored TRELEGY milestones and guided R&D and SG&A spending. Today’s FY2025 update extends that narrative with record profitability and detailed restructuring plans following the CYPRESS outcome.
Key Terms
non-gaap financial
long-acting muscarinic antagonist medical
bronchodilator medical
chronic obstructive pulmonary disease medical
phase 3 medical
milestone payment financial
income from operations financial
AI-generated analysis. How Rhea-AI works. Not financial advice.
- Organizational restructuring and cost reduction plan following results of the Phase 3 CYPRESS study of ampreloxetine are underway; expected to generate
$60 $70 million - Strategic Review Committee accelerating evaluation of opportunities to maximize shareholder value
- YUPELRI® achieved record brand profitability for Q4 and full-year 2025; full-year net sales of
$266.6 million 12% year-over-year1 resulting in a$25 million - Full-year 2025 TRELEGY net sales, reported by GSK, of
$3.9 billion 12% year-over-year, triggered a$50 million $100 million - All-time high non-GAAP profitability achieved for the second consecutive quarter3
- Company expects to have approximately
$400 million
"We ended 2025 on a positive note from a financial perspective, achieving another record quarter of non-GAAP profitability, hitting a new all-time high for YUPELRI® brand-level profitability, and reaching
Strategic Review Committee
In 2024, the Theravance Board of Directors formed a Strategic Review Committee (the "Committee") composed entirely of independent directors to assess all strategic alternatives available to the Company. Since then, the Committee has been working on an ongoing basis with Lazard, its independent financial advisor, to evaluate opportunities to maximize shareholder value, including under multiple potential outcomes for the CYPRESS study, which the Company announced on March 3rd did not meet the primary endpoint. Building upon this work, the Committee is acting with urgency to evaluate a broad range of value maximizing and tax efficient alternatives, including but not limited to a sale of the Company. In connection with the Company's March 3rd announcement to wind down the ampreloxetine program and implement an organizational restructuring, the Committee has accelerated its evaluation of strategic alternatives for the Company. There can be no assurance that the Committee's strategic review process will result in any transaction. Theravance Biopharma does not intend to disclose further developments on this review process unless and until it determines that such disclosure is appropriate or necessary.
Operational Highlights
YUPELRI® (revefenacin) inhalation solution, the first and only once-daily, nebulized LAMA (long-acting muscarinic antagonist) bronchodilator approved in the U.S. for the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD):
- Annual
U.S. net sales of$266.6 million 12% year-over-year (YoY) (FY 2025 vs FY 2024)1 triggered$25 million - Quarterly
U.S. net sales of$70.6 million 6% year-over-year (YoY) (Q4 2025 vs Q4 2024)1 driven by strong customer demand growth of14% YoY (Q4 2025 vs Q4 2024)4, offset by timing of customer purchasing patterns. - Increased doses pulled through the hospital channel by
13% YoY (Q4 2025 vs Q4 2024), reflecting another solid quarter of growth.5
TRELEGY
GSK reported fourth quarter 2025 global net sales of approximately
- FY 2025 global net sales of approximately
$3.9 billion $50M - FY 2026 global net sales of
~ required to trigger an additional$3.5 billion $100M
Organizational Restructuring Update
- Following the announcement of the Company's Phase 3 CYPRESS results, Theravance has made progress on its organizational restructuring.
- The wind-down of the R&D organization is underway and is expected to be largely complete by the beginning of the third quarter of 2026.
- The Company reaffirms it is on track to reduce operating expenses by approximately
60% , resulting in approximately$60 $70 million
Fourth Quarter Financial Results
- Revenue: Total revenue for the fourth quarter of 2025 was
$45.9 million $20.9 million $25.0 million $2.1 million 11% , in the fourth quarter compared to the same period in 2024. The Viatris collaboration revenue represents amounts receivable from Viatris and comprises the Company's35% share of net sales of YUPELRI, as well as its proportionate amount of the total shared commercial costs incurred by the two companies. The non-shared YUPELRI costs incurred by Theravance Biopharma are recorded within operating expenses. While Viatris records the total net sales of YUPELRI within its financial statements, Theravance Biopharma's implied35% share of net sales of YUPELRI for the fourth quarter of 2025 was$24.7 million 6% increase compared to the same period in 2024. - Research and Development (R&D) Expenses: R&D expenses for the fourth quarter of 2025 were
$7.4 million $9.5 million $1.0 million $33.3
million which was within our Financial Guidance of$32 million $38 million - Selling, General and Administrative (SG&A) Expenses: SG&A expenses for the fourth quarter of 2025 were
$18.5 million $3.5 million $59.3 million $50 million $60 million - Share-Based Compensation: Share-based compensation expenses for the fourth quarter of 2025 were
$4.5 million $5.8 million $1.0 million $3.5 million $1.4 million $4.4 million $18.5 million $18 million $20 million - TRELEGY Milestone Income: The Company recognized
$50.0 million - Income Taxes: Income tax expense for the fourth quarter of 2025 was
$12.0 million $6.6 million $50.0 million - Net Income: Net income was
$61.0 million $15.5 million $25.0 million $50.0 million - Non-GAAP Net Income (Loss) from Operations3: Non-GAAP net income from operations was
$3.1 million $2.5 million - Cash Position: Cash, cash equivalents and marketable securities totaled
$326.5 million $25.0 million U.S. sales milestone from Viatris in January 2026 and a$50.0 million $400.0 million - Shares Outstanding: The Company had 51,068,545 ordinary shares outstanding as of December 31, 2025.
2026 Financial Guidance
Theravance Biopharma is implementing an organizational restructuring to streamline costs and align its resources with its commercial focus on YUPELRI. The restructuring will involve winding down the R&D function and significantly reducing the G&A function. The restructuring is expected to reduce operating expenses by approximately
Together, the cost savings from the restructuring and continued sales from YUPELRI are expected to result in the Company generating approximately
The restructuring is expected to impact approximately
Conference Call
Beginning with this quarter, earnings results will be released via press release only. The Company will not host a conference call or webcast to discuss quarterly results.
About Theravance Biopharma
Theravance Biopharma, Inc.'s focus is to deliver Medicines that Make a Difference® in people's lives. In pursuit of its purpose, Theravance Biopharma leverages decades of expertise, which has led to the development of FDA-approved YUPELRI® (revefenacin) inhalation solution indicated for the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD). The Company is committed to creating/driving shareholder value.
For more information, please visit www.theravance.com.
THERAVANCE BIOPHARMA®, THERAVANCE® and the Cross/Star logo are registered trademarks of the Theravance Biopharma group of companies (in the U.S. and certain other countries).
YUPELRI® is a registered trademark of Viatris Specialty LLC. Trademarks, trade names or service marks of other companies appearing on this press release are the property of their respective owners.
Forward-Looking Statements
This press release contains certain "forward-looking" statements as that term is defined in the Private Securities Litigation Reform Act of 1995 regarding, among other things, statements relating to goals, plans, objectives, expectations and future events. Theravance Biopharma, Inc. (the "Company") intends such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. Examples of such statements include statements relating to: the Company's expectations regarding its future profitability, expenses and uses of cash, the Company's goals, designs, strategies, plans and objectives, future growth of YUPELRI sales and future royalty payments, the winddown of the Company's ampreloxetine program and R&D function and significant reduction of its G&A function, the consideration of strategic alternatives for the Company, the ability to provide value to shareholders, the Company's regulatory strategies, the status of patent infringement litigation initiated by the Company and its partner against certain generic companies in federal district courts, and contingent milestone payments due to the Company from the sale of the Company's TRELEGY royalty interests. These statements are based on the current estimates and assumptions of the management of Theravance Biopharma as of the date of this press release and are subject to risks, uncertainties, changes in circumstances, assumptions and other factors that may cause the actual results of Theravance Biopharma to be materially different from those reflected in the forward-looking statements. Important factors that could cause actual results to differ materially from those indicated by such forward-looking statements include, among others, risks related to: factors that could increase the Company's expenses beyond its expectations and any factors that could adversely affect its profitability, whether the TRELEGY milestone thresholds will be achieved, delays or difficulties in winding down clinical studies, the timing of any potential strategic transaction with respect to the Company, if at all, risks of collaborating with or relying on third parties to develop, manufacture and commercialize products, and risks associated with establishing and maintaining sales, marketing and distribution capabilities with appropriate technical expertise and supporting infrastructure, the ability of the Company to protect and to enforce its intellectual property rights, volatility and fluctuations in the trading price and volume of the Company's shares, and general economic and market conditions. Other risks affecting the Company are in the Company's Form 10-Q filed with the SEC on November 12, 2025, and other periodic reports filed with the SEC. In addition to the risks described above and in Theravance Biopharma's filings with the SEC, other unknown or unpredictable factors also could affect Theravance Biopharma's results. No forward-looking statements can be guaranteed, and actual results may differ materially from such statements. Given these uncertainties, you should not place undue reliance on these forward-looking statements. Theravance Biopharma assumes no obligation to update its forward-looking statements on account of new information, future events or otherwise, except as required by law.
Non-GAAP Financial Measures
Theravance Biopharma provides a non-GAAP metric in this press release. Theravance Biopharma believes that non-GAAP net income (loss) provides meaningful information to assist investors in assessing prospects for future performance and actual performance as they provide better metrics for analyzing the performance of its business by excluding items that may not be indicative of core operating results and the Company's cash position. Because non-GAAP financial targets and metrics, such as non-GAAP net income (loss), are not standardized, it may not be possible to compare these measures with other companies' non-GAAP targets or measures having the same or a similar name. Thus, Theravance Biopharma's non-GAAP measures should be considered in addition to, not as a substitute for, or in isolation from, the Company's actual GAAP results and other targets.
Please see the appendix attached to this press release for a reconciliation of non-GAAP net income (loss) to its corresponding measure, net income (loss). A reconciliation of non-GAAP net income (loss) to its corresponding GAAP measure is not available on a forward-looking basis without unreasonable effort due to the uncertainty regarding, and the potential variability of, expenses and other factors in the future.
Contact:
investor.relations@theravance.com
650-808-4045
___________________ | |
1 | In the |
2 | Payment from Royalty Pharma (RP) will be triggered if RP receives certain minimum royalty payments from GSK based on TRELEGY |
3 | Non-GAAP profit (loss) consists of GAAP net income (loss) before taxes less (i) share-based compensation expense, (ii) non-cash |
4 | Source: Viatris Customer Demand (Q3'25). |
5 | Source: IQVIA DDD, HDS, VA and Non-Reporting Hospital through Sept '25. |
6 | GSK-reported Net Sales in USD. |
THERAVANCE BIOPHARMA, INC | |||||
CONDENSED CONSOLIDATED BALANCE SHEETS | |||||
(In thousands) | |||||
December 31, | December 31, | ||||
2025 | 2024 | ||||
Assets | (Unaudited) | (1) | |||
Current assets: | |||||
Cash and cash equivalents and short-term marketable securities | $ | 315,357 | $ | 88,350 | |
Receivables from collaborative arrangements | 45,539 | 18,440 | |||
Receivables from milestone and royalty assets | 50,000 | 50,000 | |||
Other prepaid and current assets | 7,564 | 4,277 | |||
Total current assets | 418,460 | 161,067 | |||
Long-term marketable securities | 11,128 | - | |||
Property and equipment, net | 5,895 | 7,418 | |||
Operating lease assets | 24,371 | 28,354 | |||
Future contingent milestone and royalty assets | - | 144,200 | |||
Restricted cash | 836 | 836 | |||
Other assets | 24,880 | 12,286 | |||
Total assets | $ | 485,570 | $ | 354,161 | |
Liabilities and Shareholders' Equity | |||||
Current liabilities | $ | 38,302 | $ | 32,085 | |
Long-term operating lease liabilities | 31,758 | 39,108 | |||
Future royalty payment contingency | 32,795 | 30,334 | |||
Unrecognized tax benefits | 85,679 | 75,199 | |||
Other long-term liabilities | 313 | 1,890 | |||
Shareholders' equity | 296,723 | 175,545 | |||
Total liabilities and shareholders' equity | $ | 485,570 | $ | 354,161 | |
________________________________ | |||||
(1) The condensed consolidated balance sheet as of December 31, 2024 has been derived from the audited consolidated financial | |||||
THERAVANCE BIOPHARMA, INC | |||||||||||||
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS | |||||||||||||
(In thousands, except per share data) | |||||||||||||
Three Months Ended December 31, | Year Ended December 31, | ||||||||||||
2025 | 2024 | 2025 | 2024 | ||||||||||
(Unaudited) | (Unaudited) | ||||||||||||
Revenue: | |||||||||||||
Viatris collaboration agreement (1) | $ | 20,891 | $ | 18,754 | $ | 74,964 | $ | 64,381 | |||||
Licensing and milestone revenue | 25,000 | - | 32,500 | - | |||||||||
Total revenue | 45,891 | 18,754 | 107,464 | 64,381 | |||||||||
Costs and expenses: | |||||||||||||
Research and development (2) | 7,362 | 9,452 | 37,414 | 37,643 | |||||||||
Selling, general and administrative (2) | 18,517 | 18,502 | 73,652 | 69,174 | |||||||||
Impairment of long-lived assets (non-cash) | - | - | - | 4,513 | |||||||||
Total costs and expenses | 25,879 | 27,954 | 111,066 | 111,330 | |||||||||
Income (loss) from operations | 20,012 | (9,200) | (3,602) | (46,949) | |||||||||
Net gain on realized contingent milestone and royalty assets | - | - | 75,137 | - | |||||||||
TRELEGY milestone income | 50,000 | - | 50,000 | - | |||||||||
Interest expense (non-cash) | (583) | (643) | (2,461) | (2,546) | |||||||||
Interest income and other income, net | 3,640 | 902 | 10,173 | 4,881 | |||||||||
Income (loss) before income taxes | 73,069 | (8,941) | 129,247 | (44,614) | |||||||||
Provision for income tax expense | (12,045) | (6,587) | (23,352) | (11,804) | |||||||||
Net income (loss) | $ | 61,024 | $ | (15,528) | $ | 105,895 | $ | (56,418) | |||||
Net income (loss) per share: | |||||||||||||
Net income (loss) per share - basic | $ | 1.20 | $ | (0.31) | $ | 2.10 | $ | (1.15) | |||||
Net income (loss) per share - diluted | $ | 1.15 | $ | (0.31) | $ | 2.06 | $ | (1.15) | |||||
Shares used to compute net income (loss) per share - basis | 50,868 | 49,306 | 50,317 | 48,847 | |||||||||
Shares used to compute net income (loss) per share - diluted | 53,053 | 49,306 | 51,507 | 48,847 | |||||||||
Non-GAAP net income (loss) | $ | 3,131 | $ | (2,472) | $ | (7,453) | $ | (16,162) | |||||
________________________________ | |||||||||||||
(1) While Viatris, Inc. records the totalYUPELRI net sales, the Company is entitled to a | |||||||||||||
with Viatris as presented below: | |||||||||||||
Three Months Ended December 31, | Year Ended December 31, | ||||||||||||
(In thousands) | 2025 | 2024 | 2025 | 2024 | |||||||||
YUPELRI net sales ( | $ | 70,563 | $ | 66,680 | $ | 266,600 | $ | 238,626 | |||||
YUPELRI net sales (Theravance Biopharma implied | 24,697 | 23,339 | 93,310 | 83,520 | |||||||||
(2) Amounts include share-based compensation expense as follows: | |||||||||||||
Three Months Ended December 31, | Year Ended December 31, | ||||||||||||
(In thousands) | 2025 | 2024 | 2025 | 2024 | |||||||||
Research and development | $ | 944 | $ | 1,377 | $ | 4,081 | $ | 5,104 | |||||
Selling, general and administrative | 3,535 | 4,449 | 14,395 | 16,289 | |||||||||
Total share-based compensation expense | $ | 4,479 | $ | 5,826 | $ | 18,476 | $ | 21,393 | |||||
THERAVANCE BIOPHARMA, INC | |||||||||||||
Reconciliation of GAAP Net Income (Loss) to Non-GAAP Net Income (Loss) | |||||||||||||
(In thousands) | |||||||||||||
Three Months Ended December 31, | Year Ended December 31, | ||||||||||||
2025 | 2024 | 2025 | 2024 | ||||||||||
(Unaudited) | (Unaudited) | ||||||||||||
GAAP net income (loss) | $ | 61,024 | $ | (15,528) | $ | 105,895 | $ | (56,418) | |||||
Adjustments: | |||||||||||||
Licensing revenue (1) | (25,000) | - | (32,500) | - | |||||||||
Net gain on realized contingent milestone and royalty assets (1) | - | - | (75,137) | - | |||||||||
TRELEGY milestone income (1) | (50,000) | (50,000) | |||||||||||
Non-cash impairment expense of long-lived assets (1) | - | - | - | 4,513 | |||||||||
Share-based compensation expense | 4,479 | 5,826 | 18,476 | 21,393 | |||||||||
Non-cash interest expense | 583 | 643 | 2,461 | 2,546 | |||||||||
Income tax expense | 12,045 | 6,587 | 23,352 | 11,804 | |||||||||
Non-GAAP net income (loss) | $ | 3,131 | $ | (2,472) | $ | (7,453) | $ | (16,162) | |||||
(1) Non-recurring item | |||||||||||||
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SOURCE Theravance Biopharma, Inc.