ScaleReady Announces multiple G-Rex® Grants have been awarded to leading investigators at Children's National Hospital

Rhea-AI Summary

ScaleReady (TECH) and partners awarded four G‑Rex Grants to Children's National Hospital totaling $375,000 to support translation of cell and gene therapies into the clinic.

Grants: $100,000 to Dr. Patrick Hanley for a G‑Rex CAR‑T manufacturing process; $150,000 shared by Drs. Keller and Hanley to move VST and TAAT workflows into G‑Rex M series bioreactors; $75,000 to Dr. Amy Hont for ATTACK TAAT; $50,000 to Dr. Cruz for CAR‑modified TAAT process development.

ScaleReady reports its G‑Rex Grant Program surpassed $40M of no‑cost product commitments and launched a free LEAN Cell & Gene event series.

Positive

• Total grants of $375,000 awarded to Children's National Hospital
• Drs. Keller and Hanley received a $150,000 grant for VST/TAAT optimization
• ScaleReady program surpassed $40M of no‑cost product commitments
• Grants support transition to G‑Rex M series closed/semi‑automated bioreactors

Negative

• None.

Insights

Cell & Gene Manufacturing Expert

ScaleReady awarded $375,000 in G-Rex Grants to advance pediatric CGT manufacturing at Children’s National.

ScaleReady and partners fund process development for G-Rex–centric manufacturing across four projects, including a $100,000 grant for a CAR-T process and a $150,000 joint award for VST and TAAT optimization. The program now exceeds $40,000,000 of no-cost product commitments, signalling sustained resource support for translation work.

These grants directly address manufacturing workflow change by enabling transition into closed, semi-automated G-Rex "M" bioreactors, which reduces manual touchpoints and aims to streamline production. The work funds both CAR-modified and TAAT cell therapy processes targeting solid tumors and viral/antigen-specific T cells.

Key dependencies include successful process transfer into the G-Rex system and subsequent regulatory-compliant scale-up. Watch for process validation milestones, any reported reductions in manual interventions, and early clinical translation steps over the next 6-24 months. Evidence here is factual and limited to the stated awards and program commitments.

ST. PAUL, Minn., Oct. 23, 2025 /PRNewswire/ -- ScaleReady, in collaboration with Wilson Wolf Manufacturing, Bio-Techne Corporation (NASDAQ: TECH) and CellReady, announced four G-Rex Grants have been awarded to faculty members at Children's National Hospital. The funding, totaling $375,000, will support the optimization and translation of various cell and gene therapy initiatives into the clinic.

Dr. Patrick Hanley, Chief & Director of Cell Therapy, received a $100,000 G-Rex Grant to develop a G-Rex centric CAR-T cell manufacturing process as a nimble, flexible, and cost-effective alternative to their current approach that relies on complex and expensive capital equipment.

Dr. Michael Keller, Translational Research Laboratory – CETI Director, and Dr. Hanley, were co-recipients of a $150,000 G-Rex Grant to support the optimization of their current Virus Specific T cell (VST) and Tumor Antigen Associate T cell (TAAT) manufacturing processes, by transitioning into the optimized G-Rex "M" series bioreactors for functionally closed and semi-automated production. This will help minimize touchpoints and streamline VST and TAAT manufacturing.

Dr. Amy Hont, Oncologist in Pediatric Hematology, received a $75,000 G-Rex Grant to support process development and implementation of closed system G-Rex manufacturing of their novel ATTACK TAAT cell therapy for the treatment of various solid tumors.

Dr. Conrad Russell Cruz, Principal Investigator, received a $50,000 G-Rex Grant to support process development and optimization of a G-Rex centric process for manufacturing CAR-modified TAAT cells for treatment of various solid tumors.

"This effort reflects the importance of working together to move promising cell and gene therapies from the lab to the patients who need them most. We're thankful for the support and eager to continue this important work," said Dr. Hanley.

"Children's National has been a leader in pediatric cell and gene-modified cell therapies (CGT) for many years. Having been in this field for decades and seeing the current headwinds the field faces, it's an honor and a privilege to be able provide G-Rex Grant funding to these highly accomplished individuals that are pioneering advancements in pediatric oncology," said John Wilson, CEO of Wilson Wolf and co-inventor of the G-Rex technology.

ScaleReady's G-Rex Grant Program has now surpassed $40M of no-cost product commitments to grant recipients with the goal of advancing the state of cell and gene-modified cell therapy (CGT) development and manufacturing. Individual Grant Awards are worth up to $300,000. G-Rex Grant Recipients also gain access to exclusive support from ScaleReady's growing consortium of G-Rex Grant Partners who bring best-in-class tools and technologies as well as unparalleled knowledge and expertise in the areas of cGMP manufacturing, quality and regulatory affairs, CGT business operations, and more.

Importantly, ScaleReady has just introduced yet another FREE program to accelerate the universal presence of highly efficient and scalable CGT manufacturing. Under this program ScaleReady has partnered with Hanson Wade to launch an event series called LEAN Cell & Gene™. All CGT entities are invited to attend and will learn how to systematically identify and eliminate waste, stabilize business operations, increase drug product quality and supply, and develop a LEAN approach to cell and gene therapy development and manufacturing.

For more information about the G-Rex® Grant Program, please contact info@scaleready.com .

For more information about LEAN Cell & Gene™, please use this link to register  for the free event series.

About ScaleReady
ScaleReady provides the field of cell and gene-modified cell therapy (CGT) with a G-Rex centric manufacturing platform that enables the world's most practical, flexible, scalable, and affordable CGT drug product development and manufacturing.

The G-Rex manufacturing platform is currently used by a rapidly growing list of over 800 organizations and is producing drug products for approximately 50% of CGT clinical trials as well as 5 commercially approved CGT drugs.

CGT entities relying on the breadth and scope of ScaleReady's expertise can expect to save years of time and millions of dollars on the path to CGT commercialization.

For more information about the ScaleReady G-Rex® Grant Program, please contact info@scaleready.com.

About Wilson Wolf Manufacturing
Wilson Wolf (www.wilsonwolf.com) is dedicated to simplifying cell and gene-modified cell (CGT) therapy research, process development, and manufacturing. This is being accomplished through its scalable G-Rex technology, which is used throughout the world in CGT applications ranging from basic research to commercial drug production.

Wilson Wolf's mission is to create hope for cancer patients, one G-Rex® device at a time.

About Bio-Techne Corporation
Bio-Techne Corporation (NASDAQ: TECH) is a global life sciences company providing innovative tools and bioactive reagents for the research and clinical diagnostic communities. Bio-Techne, in partnership with Wilson Wolf, is creating products such as media and cytokines that are specifically tailored to G-Rex® Bioreactors, including right-sized reagent quantities in containers that are tailored to high throughput closed-system manufacturing. For more information on Bio-Techne and its brands, please visit https://www.bio-techne.com or follow the Company on social media at LinkedIn, X, or YouTube.

Contact: David Clair, Vice President, Investor Relations & Corporate Development
david.clair@bio-techne.com
612-656-4416

About CellReady LLC
CellReady is the world's first and only G-Rex centric contract development and manufacturing organization (CDMO) specializing in G-Rex based cell and gene-modified cell therapy development and manufacturing. The company offers a wide range of services to support the development and commercialization of these therapies.

CellReady's mission is to create hope for cancer patients, one G-Rex® process at a time.

About Children's National Hospital
Children's National Hospital, based in Washington, D.C., was established in 1870 to help every child grow up stronger. Today, it is one of the top 10 children's hospitals in the nation and ranked in all specialties evaluated by U.S. News & World Report. Children's National is transforming pediatric medicine for all children. The Children's National Research & Innovation Campus opened in 2021, a first-of-its-kind pediatric hub dedicated to developing new and better ways to care for kids. Children's National has been designated four times in a row as a Magnet^® hospital, demonstrating the highest standards of nursing and patient care delivery. This pediatric academic health system offers expert care through a convenient, community-based primary care network and specialty care locations in the D.C. metropolitan area, including Maryland and Virginia. Children's National is home to the Children's National Research Institute and Sheikh Zayed Institute for Pediatric Surgical Innovation. It is recognized for its expertise and innovation in pediatric care and as a strong voice for children through advocacy at the local, regional and national levels. In 1987, Children's National founded Safe Kids Worldwide, a non-profit dedicated to reducing unintentional injuries among children through comprehensive national and global education, research and advocacy. As a non-profit, Children's National relies on generous donors to help ensure that every child receives the care they need.

For more information, follow us on Facebook, Instagram and LinkedIn.

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SOURCE Bio-Techne Corporation

FAQ

How much funding did ScaleReady and partners award to Children's National Hospital on October 23, 2025?

They awarded a total of $375,000 in four G‑Rex Grants on October 23, 2025.

What is the $150,000 G‑Rex Grant for (TECH) awarded to Drs. Keller and Hanley?

The $150,000 grant supports optimization of VST and TAAT manufacturing and transition to G‑Rex M series bioreactors.

What clinical programs at Children's National received G‑Rex Grant support from ScaleReady (TECH)?

Grants support CAR‑T manufacturing, VST and TAAT processes, ATTACK TAAT for solid tumors, and CAR‑modified TAAT development.

What milestone did ScaleReady report about its G‑Rex Grant Program in October 2025?

ScaleReady reported the G‑Rex Grant Program surpassed $40M of no‑cost product commitments.

What is LEAN Cell & Gene™ and how does it relate to ScaleReady (TECH)?

LEAN Cell & Gene™ is a free event series launched with Hanson Wade to teach LEAN manufacturing practices for CGT development.