Telomir Pharmaceuticals Announces Significant Reduction of Oxidative Stress in Human Retinal Cell Lines, Advancing Potential Treatment for Age-Related Macular Degeneration (AMD)

Rhea-AI Summary

Telomir Pharmaceuticals (NASDAQ:TELO) has announced breakthrough results from preclinical studies of Telomir-1 in human retinal cell lines, showing significant reduction of copper and iron-induced Reactive Oxygen Species (ROS). The studies demonstrate potential treatment for Age-Related Macular Degeneration (AMD), a leading cause of blindness in adults over 50.

The research revealed that Telomir-1 effectively reduced ROS levels at low concentrations, suggesting regulatory properties rather than chelation effects. This indicates promising therapeutic potential for AMD treatment. The compound targets oxidative stress and metal-induced toxicity, key factors in AMD progression, offering a novel approach compared to current treatments that mainly manage symptoms.

The company plans to conduct AMD disease models to evaluate Telomir-1's efficacy in vivo, while also expanding research into other conditions including Wilson's disease, progeria, cancer, Alzheimer's, and infectious diseases.

Positive

• Successful preclinical results showing significant reduction of oxidative stress in human retinal cells
• Telomir-1 demonstrated effectiveness at low concentrations, indicating high therapeutic potential
• Novel approach targeting root causes rather than symptoms, potentially offering better treatment options

Negative

• Still in preclinical stage, requiring further studies and clinical trials before potential commercialization
• No concrete timeline provided for clinical development
• Multiple competing treatment approaches already exist in the market

MIAMI, FLORIDA / ACCESS Newswire / February 18, 2025 / Telomir Pharmaceuticals, Inc. (NASDAQ:TELO), or Telomir, a leader in age-reversal science, today announced groundbreaking results from its recent preclinical studies conducted in human retinal cell lines. These studies demonstrated the ability of Telomir-1 to significantly reverse copper and iron-induced elevation of Reactive Oxygen Species (ROS).

Age-Related Macular Degeneration (AMD) and Current Treatment Challenges

AMD is a leading cause of blindness in adults over 50, affecting millions worldwide. The disease is characterized by the progressive deterioration of the retinal pigment epithelium (RPE) and photoreceptor cells, leading to central vision loss. AMD is classified into two forms:

• Dry (atrophic) AMD, the most common form, which is characterized by a gradual loss of RPE and photoreceptors due to oxidative stress and inflammation.

• Wet (neovascular) AMD, a more severe form, where abnormal blood vessel growth causes rapid and severe vision loss.

Current treatments primarily aim to slow the progression of AMD rather than reverse the damage. Anti-VEGF injections, the standard for wet AMD, can reduce vision loss but require frequent and costly treatments with potential risks such as retinal detachment and infection. The AREDS2 formula, an antioxidant supplement, offers modest benefits in delaying intermediate AMD but does not restore lost vision. Laser and photodynamic therapies, once widely used, are now less common due to risks of retinal scarring and limited long-term efficacy. While gene and stem cell therapies are emerging, no FDA-approved treatments directly target oxidative stress, a key factor in AMD progression.

Despite these treatments, there remains an urgent need for therapies that address the root causes of AMD, particularly oxidative stress and metal-induced toxicity, which drive retinal degeneration. Telomir-1 represents a novel approach by targeting these underlying mechanisms, offering a potential disease-modifying solution rather than just slowing its effects.

"The continued success of Telomir-1 in regulating oxidative stress is further proof of its potential to transform healthcare and redefine how we approach aging and age-related diseases," said Erez Aminov, Chairman & CEO of Telomir. "Rather than merely addressing symptoms, our focus is on targeting the root causes of disease at the cellular level. Telomir-1's ability to mitigate oxidative damage underscores its promise as a breakthrough therapy, not only for AMD but for a broader range of age-related conditions."

Telomir-1: A Novel Approach to Combating Oxidative Stress in AMD

Telomir's lead compound, Telomir-1, was developed to neutralize metal-induced oxidative stress-a key driver of AMD progression. In a recently conducted preclinical study using human retinal cell lines, Telomir-1 demonstrated the ability to significantly reduce ROS levels, thereby reversing oxidative damage, suggesting therapeutic potential in AMD and other retinal diseases.

Key Study Findings:

• Copper and iron exposure significantly increased ROS levels in human retinal cells, accelerating oxidative stress and cellular damage.

• Telomir-1 treatment resulted in a significant reduction of copper and iron-induced ROS elevation, mitigating oxidative stress at the cellular level.

• Telomir-1 exhibited strong ROS reduction properties at low concentrations, suggesting regulatory, rather than chelation properties, and a high therapeutic potential for AMD.

• The ability to reduce oxidative stress may have implications beyond AMD, potentially benefiting other retinal diseases linked to oxidative damage.

"Our findings reinforce the crucial role of metal ions and oxidative stress in AMD and suggest that Telomir-1 could provide a breakthrough approach to protecting retinal cells from degeneration," said Dr. Angel, Chief Scientific Advisor at Telomir. "Unlike current AMD treatments that primarily manage symptoms, Telomir-1 directly targets oxidative stress and metal-induced toxicity, key factors in disease progression."

Next Steps in Telomir-1 Development

Telomir has planned AMD disease models to further evaluate the efficacy of Telomir-1 in vivo. These studies will explore how Telomir-1 can protect against progressive retinal degeneration and vision loss, paving the way for potential clinical development.

In addition to AMD, Telomir will be conducting studies to evaluate the potential of Telomir-1 in Wilson's disease, progeria, cancer, Alzheimer's, and other age-related conditions. Furthermore, research will be expanded into infectious diseases, including influenza and bird flu, to assess how Telomir-1's metal ion regulation capabilities may impact viral pathogenesis and immune response.

About Telomir Pharmaceuticals, Inc.

Telomir Pharmaceuticals, Inc. (NASDAQ:TELO) is a pre-clinical stage pharmaceutical company seeking to lead development in several areas, including age-reversal science. Telomir is focused on the development of Telomir-1, a novel small molecule metal ion regulator designed to lengthen the DNA's protective telomere caps, which are crucial in the aging process. Telomir's goal is to explore the potential of Telomir-1, starting with ongoing research in animals and then in humans.

Telomeres are the protective end caps of a chromosome made up of DNA sequences and proteins. As humans age, telomeres shorten, with metal reactivity accelerating the process, which presents humans and pet animals with an increased chance of contracting a number of degenerative and age-related diseases. Telomir's goal is to develop and gain regulatory approval for Telomir-1, proposed to be dosed orally, with the broader aim of promoting longevity and enhancing overall quality of life.

Telomir-1 is in preclinical development and has not yet been tested in humans. There is no assurance that Telomir-1 will proceed through development or will ultimately receive FDA approval for marketing.

Cautionary Note Regarding Forward-Looking Statements

This press release, statements of Telomir Pharmaceuticals' management or advisors related thereto, and the statements contained in the news story linked in this release contain "forward-looking statements," which are statements other than historical facts made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These risks and uncertainties include, but are not limited to, the potential use of the data from our studies, our ability to develop and commercialize Telomir-1 for specific indications, and the safety of Telomir-1.

Contact Information

Helga Moya
info@telomirpharma.com
(786) 396-6723

SOURCE: Telomir Pharmaceuticals, Inc

View the original press release on ACCESS Newswire

FAQ

What are the key findings of TELO's recent preclinical studies for AMD treatment?

Telomir-1 demonstrated significant reduction of copper and iron-induced ROS elevation in human retinal cells, showing effectiveness at low concentrations and suggesting regulatory properties rather than chelation effects.

How does Telomir-1's approach to AMD treatment differ from current treatments?

Telomir-1 targets the root causes of AMD by directly addressing oxidative stress and metal-induced toxicity, while current treatments primarily focus on managing symptoms and slowing disease progression.

What are TELO's next development steps for Telomir-1?

Telomir plans to conduct AMD disease models to evaluate Telomir-1's efficacy in vivo and expand research into other conditions including Wilson's disease, progeria, cancer, Alzheimer's, and infectious diseases.

What potential market does TELO's AMD treatment target?

The treatment targets AMD, a leading cause of blindness in adults over 50, affecting millions worldwide, with both dry and wet forms of the disease.