Tempus AI Stock Price, News & Analysis

Tempus AI (NASDAQ: TEM) has completed its acquisition of Ambry Genetics, a genetic testing company focused on understanding genetics-disease relationships. The transaction, valued at $600 million total, consists of $375 million in cash and $225 million in shares, with $100 million subject to a one-year lock-up period. The acquisition was financed by Ares Management Credit funds.

Tempus CEO Eric Lefkofsky emphasized that this strategic acquisition enhances their capability to deliver advanced solutions to clinicians, patients, and life sciences companies by combining diagnostics and data. Ambry Genetics will continue operating as a wholly-owned subsidiary of Tempus, maintaining its current leadership team.

Genialis has extended its collaboration with Debiopharm to develop predictive biomarkers for WEE1-targeted therapy in cancer treatment. The partnership, building on a 2024 agreement, focuses on discovering biomarkers within the DNA damage response (DDR) biological space. Debiopharm's WEE1 asset is currently in Phase 1 clinical research.

The collaboration leverages the Genialis™ Supermodel, an AI-powered foundation model that enables rapid biomarker configuration across cancer drug targets. This technology, trained on hundreds of thousands of RNA-seq samples, helps stratify response groups and identify mechanisms of response and resistance.

The announcement follows Genialis' recent multi-year agreement with Tempus AI (NASDAQ: TEM) to validate RNA-based biomarker algorithms using Tempus' multimodal dataset. Genialis will present their findings at the 8th Annual DDR Inhibitors Summit and AACR Annual Meeting in 2025.

Tempus (NASDAQ: TEM) has announced the national launch of olivia, an AI-enabled personal health concierge app designed to centralize patient health data and make it actionable. The app connects to over 1,000 health systems through EHR integration and allows users to sync health device data or manually upload records.

Key features include: AI-generated smart profile summaries detailing clinical diagnoses and medications; AI-enabled notetaker for physician appointments; DICOM image sharing through a browser-native platform called pixel; health monitoring capabilities with Apple Health and Google Fit integration; and direct data import from healthcare providers.

The app organizes health information into a dynamic timeline, allowing patients to access records, lab results, and imaging reports. Users can query their health data using natural language, receiving AI-powered responses and insights. olivia is now available on both iOS and Android platforms.

Tempus AI (NASDAQ: TEM) has announced the nationwide launch of its FDA-approved xT CDx test, a comprehensive 648-gene next-generation sequencing test for solid tumor profiling. The test includes microsatellite instability status and companion diagnostic claims for colorectal cancer patients.

The xT CDx employs a normal-matched approach, conducting parallel DNA sequencing of solid tumor and normal patient samples for more accurate identification of cancer-driving somatic variants. All existing tumor + normal match tests previously run on Tempus's signature xT assay will now be processed as xT CDx, maintaining the current ordering workflow.

Clinicians can enhance molecular insights by combining xT CDx with additional tests including xR RNA sequencing, xF/xF+ liquid biopsy, immunohistochemistry tests, and algorithmic tests for homologous recombination deficiency and immune profile scoring.

Tempus AI (NASDAQ: TEM) has unveiled new generative AI capabilities for its Tempus One platform, enhancing its ability to analyze unstructured healthcare data. The platform now features four key innovations: Patient Query for improved clinical trial matching, Patient Timeline for comprehensive patient journey visualization, Prior Authorization to streamline administrative processes, and Data Exploration for advanced research capabilities.

These new features leverage Tempus' proprietary Large Language Model (LLM) Agent Infrastructure to process millions of unstructured documents, including progress notes, pathology reports, and imaging scans. The system can now create structured timelines of clinical events, facilitate patient enrollment in clinical trials, assist with prior authorization documentation, and enable researchers to analyze de-identified datasets more efficiently.

Tempus AI (NASDAQ: TEM) announced the development of xH, its first whole-genome sequencing (WGS) test, focusing on hematological oncology. The test, currently available for research use only, will be clinically available within the next year. xH is designed to support both clinicians and biopharma collaborators by providing comprehensive genetic profiling.

In a pilot study of 135 patients, the WGS assay demonstrated high accuracy with a concordance rate exceeding 98.9% compared to traditional molecular methods. The test showed particular effectiveness in detecting guideline-recommended structural variants and large copy number alterations in myeloid malignancies, including Acute Myeloid Leukemia, Myelodysplastic Syndromes, and Myeloproliferative neoplasms. This comprehensive approach aims to consolidate multiple tests into a single assay, potentially offering a more cost-effective solution for genomic profiling.

Tempus AI (NASDAQ: TEM) released preliminary, unaudited results for Q4 and full year 2024. The company reported approximate full-year revenue of $693 million, showing ~30% year-over-year growth, and Q4 revenue of $200 million, representing ~35% year-over-year growth.

The company's genomics revenue is expected to grow ~30% in Q4, while data and services revenue is projected to grow ~45%. Tempus expects to achieve ~99% of its 2024 revenue guidance and ~100% of adjusted EBITDA guidance, despite noting some softness in CRO revenues. Both Q4 and full-year results showed continued improvement in adjusted EBITDA compared to previous periods.

These preliminary results are subject to change pending completion of year-end close and review procedures. Final detailed financial results will be reported during the company's first earnings call of 2025.

Tempus (NASDAQ: TEM) announced a multi-year collaboration with Genialis to develop RNA-based biomarker algorithms for cancer treatment. Genialis will utilize Tempus' multimodal dataset to validate and enhance their AI foundation model, which uses data from approximately 1 million RNA-sequencing samples.

Through this partnership, Genialis gains access to Tempus' analytics platform, Lens, providing development tools and de-identified patient records. In return, Tempus receives rights to evaluate and potentially license Genialis-developed algorithms for commercialization within their xR platform.

The collaboration has already contributed to the launch of Genialis™krasID, the first commercial algorithm predicting patient response to KRAS-targeted therapies across cancer types. This algorithm, validated using Tempus' real-world data, effectively stratifies patients into response likelihood groups.

Tempus AI (NASDAQ: TEM) has announced its participation in the 43rd Annual J.P. Morgan Healthcare Conference, scheduled for January 13-16, 2025, in San Francisco. The company's involvement includes two key events:

1. A presentation and Q&A session with investors led by Founder and CEO Eric Lefkofsky on Monday, January 13

2. A panel discussion on Policy Outlook for Artificial Intelligence in Healthcare & Diagnostics featuring Chief Scientific Officer Kate Sasser on Wednesday, January 15

The company will provide a live webcast option for accessing the January 13 presentation. Tempus AI specializes in leveraging artificial intelligence to enhance precision medicine and improve patient care outcomes.