Tiziana Life Sciences Ltd. develops intranasal foralumab, a fully human anti-CD3 monoclonal antibody, as a clinical-stage biotechnology company focused on neuroinflammatory and neurodegenerative diseases. News for TLSA centers on clinical and preclinical data for intranasal anti-CD3 therapy, including non-active secondary progressive multiple sclerosis, Multiple System Atrophy, Alzheimer’s disease, ALS, Long COVID-associated neuroinflammation, and age-related cognitive decline.
Company updates also cover biomarker work involving CSF proteomics, TSPO-PET and microglial activation, peer-reviewed publications, scientific conference presentations, expanded-access observations, and financing actions such as registered direct offerings of ordinary shares and warrants.
Tiziana Life Sciences (NASDAQ: TLSA) announced that CEO Kunwar Shailubhai will present at the BIO Annual Convention in San Diego from June 13-16, 2022. His focus will be on recent clinical updates for foralumab, an anti-CD3 monoclonal antibody, specifically regarding nasal administration for secondary progressive multiple sclerosis. Additionally, he will discuss the Phase 1b trial for oral capsules of foralumab aimed at treating Crohn’s Disease. Tiziana's management will also conduct one-on-one meetings at the event.
Tiziana Life Sciences (TLSA) announced Dr. Tanuja Chitnis will present clinical data on foralumab, an intranasal anti-CD3 monoclonal antibody, at the CMSC 2022 Annual Meeting from June 1-4. This presentation will focus on a patient with secondary progressive multiple sclerosis treated for six months. The data highlights the potential of foralumab to reduce microglial activation and blood inflammatory markers. The session is scheduled for June 2, 2022, at 5 PM EDT. Foralumab, a unique human anti-CD3 mAb, shows promise in treating autoimmune diseases.
Tiziana Life Sciences (Nasdaq: TLSA) announced the filing of its Annual Report on Form 20-F for the year ended December 31, 2021, on May 23, 2022. Following this filing, the company confirmed it has regained compliance with Nasdaq Listing Rules. Tiziana is focused on developing innovative immunotherapy delivery methods, including intranasal foralumab, which is the only fully human anti-CD3 monoclonal antibody, and milciclib, a pan-CDK inhibitor. The company’s alternative drug delivery technologies aim to enhance efficacy, safety, and tolerability.
Tiziana Life Sciences Ltd (NASDAQ: TLSA) announced that its CEO and CSO, Kunwar Shailubhai, Ph.D., will participate in a fireside chat at the B. Riley Securities 2022 Virtual Neuro & Ophthalmology Conference on April 27, 2022, at 2:30 p.m. ET. The discussion will focus on updates regarding the company's innovative biopharmaceutical developments, particularly its intranasal foralumab treatment for Secondary Progressive Multiple Sclerosis. Tiziana aims to revolutionize immunotherapy delivery with its novel approaches.
Tiziana Life Sciences (TLSA) has received FDA approval to expand its Intermediate-Size Patient Population Access program for its intranasal foralumab treatment in secondary progressive multiple sclerosis (SPMS). Following promising clinical responses from two patients, Tiziana aims to initiate treatment for eight additional patients. The dosing regimen will remain at 50 mcg three times a week, with the potential for dose escalation. The study is expected to begin in July 2022, focusing on safety, tolerability, and clinical benefits.
Tiziana Life Sciences (NASDAQ: TLSA) has initiated a Phase 1b clinical trial for foralumab, an oral immunotherapy for mild-to-moderate Crohn's Disease (CD). This trial, expected to conclude by Q4 2022, aims to evaluate the safety and tolerability of a new enteric-coated capsule formulation. The study will also assess clinical responses and pharmacokinetics. Foralumab represents a significant departure from traditional intravenous or subcutaneous therapies, potentially offering improved patient compliance and fewer side effects.
Tiziana Life Sciences (Nasdaq: TLSA) announces the replay availability of its March 14 KOL event, "Foralumab Clinical Update in Multiple Sclerosis," along with presentation slides on its website. Zacks released a research note discussing positive clinical data for a SPMS patient treated for six months. Tiziana is focused on innovative immunotherapy approaches, including intranasal foralumab and milciclib, which have shown favorable safety profiles in studies. The company is advancing transformational drug delivery technologies aimed at improving efficacy and safety.
Tiziana Life Sciences (Nasdaq: TLSA) announced a virtual Key Opinion Leader webinar scheduled for March 14, 2022, focusing on the clinical updates of foralumab in multiple sclerosis. Renowned experts, including Prof. Howard Weiner from Harvard, will discuss the significance of intranasal immunotherapy for neurodegenerative diseases. The event aims to detail recent clinical data where patients with Secondary Progressive Multiple Sclerosis were treated with foralumab. Attendees can register online and submit questions to the panel.
Tiziana Life Sciences (Nasdaq: TLSA) announced positive results from a six-month clinical trial of intranasal foralumab in a patient with Secondary Progressive Multiple Sclerosis (SPMS). The treatment was well-tolerated with no adverse reactions. Significant biological improvements included sustained inhibition of microglial activation and reduction of pro-inflammatory cytokines. The FDA authorized a second patient to receive therapy under an Expanded Access IND. A Key Opinion Leader (KOL) event will be held on March 14, 2022, to discuss findings.
Tiziana Life Sciences Ltd. (Nasdaq: TLSA) announced that its former subsidiary, AccuStem Sciences, published new data demonstrating that StemPrintER is a strong prognostic tool for distant recurrence risk in breast cancer. Analyzing 776 tumor samples from the TransATAC cohort showed that patients with a low StemPrintER Risk Score had a 5.8% risk of distant recurrence at 10 years, compared to 23.2% for high scores. This indicates StemPrintER's potential in clinical decision-making, alongside established tests.