Tango Therapeutics Reports First Quarter 2025 Financial Results and Provides Business Highlights
- Strong cash position of $216.7M with runway extended into Q1 2027
- TNG462 advancing towards registrational trial in pancreatic cancer next year
- Multiple pipeline catalysts expected in 2H 2025 including TNG462 and TNG260 data updates
- Strategic partnership with Revolution Medicines for combination trials
- Proof-of-mechanism established for TNG260 with favorable safety profile
- Collaboration revenue declined from $6.5M to $5.4M year-over-year
- Net loss increased to $39.9M from $37.9M year-over-year
- Reduction in preclinical pipeline and research headcount to preserve cash
- Deferral of some clinical combination studies
Insights
Tango extends cash runway to Q1 2027 by narrowing focus to PRMT5 inhibitors while advancing TNG462 toward registrational trials in pancreatic cancer.
Tango Therapeutics has strategically pivoted its resources toward its lead PRMT5 inhibitor programs while extending its cash runway. The company reported
The company's strategic focus centers on TNG462, their potentially best-in-class MTA-cooperative PRMT5 inhibitor. Management has expressed strong conviction in this program, with plans for a data update in H2 2025 that should inform a registrational trial in pancreatic cancer in 2026. This represents a significant milestone as the company transitions from early clinical development toward potential commercialization.
Most intriguing is Tango's emphasis on combination strategies with Revolution Medicines' RAS(ON) inhibitors (daraxonrasib and zoldonrasib), expected to begin enrolling in Q2 2025. This approach targeting two critical cancer pathways simultaneously – PRMT5 and RAS – demonstrates scientific sophistication in addressing hard-to-treat cancers like pancreatic and lung cancer.
The financial position shows modest revenue decline (
Particularly noteworthy is management's transparent prioritization amid challenging market conditions, focusing resources on programs with the strongest data while maintaining a disciplined approach to capital allocation – an encouraging sign of thoughtful leadership making difficult but necessary decisions to maximize shareholder value.
– Data update from ongoing TNG462 Phase 1/2 monotherapy trial expected 2H 2025 –
– Combination trial of TNG462 + Revolution Medicines RAS(ON) inhibitors on track for enrollment 2Q 2025 –
– Cash position of
BOSTON, May 12, 2025 (GLOBE NEWSWIRE) -- Tango Therapeutics, Inc. (NASDAQ: TNGX), a clinical-stage biotechnology company committed to discovering and delivering the next generation of precision cancer medicines, reported its financial results for the first quarter ended March 31, 2025, and provided business highlights.
“Accumulating data continue to support TNG462 as the potential best-in-class PRMT5 inhibitor,” said Barbara Weber, M.D., President and CEO of Tango Therapeutics. “We anticipate presenting a fulsome efficacy, safety and tolerability data update on TNG462 monotherapy later this year, with a focus on pancreatic and lung cancer, and remain on track with our goal of initiating our first TNG462 monotherapy registrational study in pancreatic cancer next year. We also are moving forward rapidly with key clinical combinations and, based on strong preclinical data, we are focused on combining TNG462 with Revolution Medicine’s RAS(ON) inhibitors daraxonrasib and zoldonrasib in pancreatic and lung cancer. Finally, given market conditions and our strong conviction in TNG462, we have taken steps to extend our cash runway and focus resources on our PRMT5 programs, reducing spend on our preclinical pipeline and deferring some clinical combination studies designed primarily to assess tolerability with standard-of-care regimens.”
Pipeline Update
TNG462, a potentially best-in-class MTA-cooperative PRMT5 inhibitor
- Enrollment in dose expansion is ongoing and a clinical data update on the TNG462 Phase 1/2 trial is expected in the second half of this year. This update is anticipated to provide sufficient information to inform a registrational trial in pancreatic cancer next year and determine the next steps for the development path in NSCLC.
- Based on promising preclinical data, the Company is on track to initiate a combination trial with TNG462, including RAS(ON) multi-selective inhibitor, daraxonrasib, and RAS(ON) G12D-selective inhibitor, zoldonrasib (Revolution Medicines). This trial is expected to begin enrolling in the second quarter of 2025.
TNG456, a next-generation brain-penetrant MTA-cooperative PRMT5 inhibitor in development for glioblastoma
- Preclinical studies demonstrate TNG456 brain exposure has the potential to be sufficient for meaningful efficacy in glioblastoma.
- The Company plans to begin enrolling a Phase 1/2 clinical trial evaluating TNG456 in patients with MTAP-deleted solid tumors, focused on glioblastoma in 2Q 2025.
TNG260, a first-in-class, highly selective CoREST complex inhibitor
- Proof-of-mechanism has been established for TNG260 based on pharmacodynamic data from on-treatment patient biopsies, with favorable safety, tolerability and pharmacokinetic profiles shown at the expansion dose of 80 mg QD (once daily) to date.
- The dose expansion cohort of the TNG260 Phase 1/2 trial is ongoing in NSCLC. The study is evaluating the pharmacokinetics, pharmacodynamics, safety and efficacy of TNG260 in combination with pembrolizumab in patients with an STK11 loss-of-function mutation.
- The Company plans to provide a clinical update on TNG260 in the second half of 2025.
TNG961, a first-in-class, potent and selective HBS1L molecular glue degrader for the treatment of cancers with FOCAD deletion
- TNG961 is a development candidate targeting HBS1L in FOCAD-deleted solid tumors. FOCAD deletion occurs in 20
-40% of all MTAP-deleted cancers and is common in NSCLC, occurring in ~7% of these patients. - 20
-40% of cancers with MTAP deletion have a coincident FOCAD deletion on chromosome 9, and cancers with FOCAD deletion are dependent on HBS1L for mRNA processing, thus protein synthesis. By degrading HBS1L and disrupting the HBS1L/PELO complex, TNG961 causes tumor regression in FOCAD-deleted preclinical models of multiple histologies.
Preclinical presentations at AACR
- The Company presented five posters at the 2025 American Association for Cancer Research (AACR) Annual Meeting, April 25-30, 2025. These posters highlight preclinical data from our PRMT5 programs and underscore the potential of these molecules as both standalone treatments and as key combination partners in MTAP-deleted cancers, including in combination with KRAS-inhibitors. Preclinical data from TNG961, an HBSL1 molecular glue degrader, also was presented.
Upcoming Milestones
- TNG462 Phase 1/2 clinical data update expected in 2H 2025
- TNG456 phase 1/2 trial enrollment expected to begin 2Q 2025
- Enrollment in combination trial with TNG462 + RAS(ON) multi-selective inhibitor, daraxonrasib and TNG462 + RAS(ON) G12D-selective inhibitor, zoldonrasib, (Revolution Medicines) expected to begin 2Q 2025
- TNG260 clinical data update expected in 2H 2025
Financial Results
As of March 31, 2025, the Company held
Collaboration revenue was
Research and development expenses were
General and administrative expenses were
Net loss for the three months ended March 31, 2025 was
About Tango Therapeutics
Tango Therapeutics is a clinical-stage biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. For more information, please visit www.tangotx.com.
Forward-Looking Statements
Certain statements in this press release may be considered forward-looking statements. Forward-looking statements generally relate to future events, Tango’s future operating performance and goals, the anticipated benefits of therapies and combination therapies (that include a Tango pipeline product), as well as the expectations, beliefs and development objectives for Tango’s product pipeline and clinical trials. In some cases, you can identify forward-looking statements by terminology such as “may”, “should”, “expect”, “intend”, “will”, “goal”, “estimate”, “anticipate”, “believe”, “predict”, “designed,” “potential” or “continue”, or the negatives of these terms or variations of them or similar terminology. For example, implicit or explicit statements concerning the following include or constitute forward-looking statements: Dr. Weber's statements in this press release and statements regarding: (i) the potential of the Company’s PRMT5 molecules, as both standalone treatments and in combination with RAS(ON)-inhibitors; (ii) the preclinical research of the Company’s PRMT5 inhibitors, as a monotherapy and in combination, and the expectation that they may pave the way for future development opportunities; (iii) expectations regarding the anticipated benefits of our molecules, including in regards to TNG456's potential to have meaningful clinical benefit in glioblastoma; (iv) expectations for TNG462, including our plans to present a fulsome efficacy, safety and tolerability update on TNG462 monotherapy in 2025 (with a focus on pancreatic and lung cancer) and our belief that TNG462 has the potential to be a best-in-class PRMT5 inhibitor; (v) beliefs regarding the ability of the ongoing TNG462 clinical trial to provide sufficient data to inform a registrational trial in pancreatic cancer and determine the next steps for a development path in lung cancer; (vi) our plans and timing for a combination trial with TNG462 and RAS(ON) inhibitors from Revolution Medicines (vii) our expectations and plans regarding TNG961; and (viii) the expected timing of: (a) development candidate declaration for certain targets; (b) initiating IND-enabling studies; (c) filing INDs; (d) clinical trial initiation, enrollment, dose escalation and dose expansion (including for combination studies); (e) disclosing initial, interim, updated, additional and final clinical trial results (including for combination studies), including expectations to present a clinical update for TNG462 and TNG260 in the second half of 2025; and (f) the expected benefits of the Company's development candidates and other product candidates. Such forward-looking statements are subject to risks, uncertainties, and other factors which could cause actual results to differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon estimates and assumptions that, while considered reasonable by Tango and its management, are inherently uncertain. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. Factors that may cause actual results to differ materially from current expectations include, but are not limited to: the benefits of product candidates seen in preclinical tests and analyses may not be evident when tested in later preclinical studies or in clinical trials or when used in broader patient populations (if approved for commercial sale); Tango has limited experience conducting clinical trials (and does and will continue to rely on a third party to operate its clinical trials) and may not be able to commence its clinical trials (including opening clinical trial sites, dosing the first patient, and continued enrollment and dosing of an adequate number of clinical trial participants) when expected, may not be able to continue dosing, initiate dose escalation and/or dose expansion on anticipated timelines, and may not generate or report clinical trial results (including final, initial, interim, updated clinical trial results or additional safety and efficacy data and the establishment of proof-of-mechanism and proof-of-concept) in the anticipated timeframe (or at all); future clinical trial data releases may differ materially from initial or interim data from our current and future clinical trials; Tango’s pipeline products may not be safe and/or effective in humans; Tango has a limited operating history and has not generated any revenue to date from product sales, and may never become profitable; other companies may be able to identify and develop product candidates more quickly than the Company and commercially introduce the product prior to the Company; the Company’s proprietary discovery platform is novel and may not identify any synthetic lethal targets for future development; the Company may not be able to identify development candidates on the schedule it anticipates due to technical, financial or other reasons; the Company may not be able to file INDs for development candidates on time, or at all, due to technical or financial reasons or otherwise; the Company may utilize cash resources more quickly than anticipated; Tango will need to raise capital in the future and if we are unable to raise capital when needed or on attractive terms, we would be forced to delay, scale back or discontinue some of our development programs or future commercialization efforts (which may delay filing of INDs, dosing patients, initiation of dose expansion, reporting clinical trial results and filing new drug applications); Tango’s approach to the discovery and development of product candidates is novel and unproven, which makes it difficult to predict the time, cost of development, and likelihood of successfully developing any products; the Company may be unable to advance our preclinical development programs into and through the clinic for safety or efficacy reasons or commercialize our product candidates or we may experience significant delays in doing so as a result of factors beyond Tango’s control; the Company may not be able to realize the benefits of orphan drug or Fast Track designation (and such designations may not advance any anticipated approval timelines); the expected benefits of our product candidates in patients as single agents and/or in combination may not be realized; the Company may experience delays or difficulties in the initiation, enrollment, or dosing of patients in clinical trials or the announcement of clinical trial results, Tango may not identify or discover additional product candidates or may expend limited resources to pursue a particular product candidate or indication and fail to capitalize on product candidates or indications that may be more profitable or for which there is a greater likelihood of success; the Company’s product candidates may cause adverse or other undesirable side effects (or may not show requisite efficacy) that could, among other things, delay or prevent regulatory approval; our dependence on one or a limited number third parties for conducting clinical trials and producing drug substance and drug product (including drug substance, which is currently sole sourced); government regulation may negatively impact the Company’s business, including the potential approval of the BIOSECURE Act; the impact of trade restrictions such as sanctions, tariffs, reciprocal and retaliatory tariffs, legal actions or enforcement and inflation rates on our business, financial condition, and results of operations; inadequate funding for or disruptions at the U.S. Food and Drug Administration or other government agencies may slow the time necessary for new drugs to be reviewed and/or approved or prevent these agencies from performing business functions on which the operation of our business may rely (which could negatively impact our business), and uncertainty around the U.S. presidential administration's approach to governmental agencies and/or product candidate approvals may present challenges for our business or create a more costly environment in which to pursue the development of new therapeutic candidates; and our ability to obtain and maintain patent and other intellectual property protection for our technology and product candidates or the scope of intellectual property protection obtained is not sufficiently broad. Additional information concerning risks, uncertainties and assumptions can be found in Tango’s filings with the Securities and Exchange Commission (SEC), including the risk factors referenced in Tango’s Annual Report on Form 10-K for the fiscal year ended December 31, 2024, as supplemented and/or modified by its most recent Quarterly Report on Form 10-Q. You should not place undue reliance on forward-looking statements in this press release, which speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Tango specifically disclaims any duty to update these forward-looking statements.
Investors and Media:
Elizabeth Hickin
IR@tangotx.com
media@tangotx.com
| Consolidated Statements of Operations | ||||||||
| (In thousands, except share and per share data) | ||||||||
| Three Months Ended March 31, | ||||||||
| 2025 | 2024 | |||||||
| Collaboration revenue | $ | 5,392 | $ | 6,471 | ||||
| Operating expenses: | ||||||||
| Research and development | 36,442 | 38,065 | ||||||
| General and administrative | 11,480 | 10,661 | ||||||
| Total operating expenses | 47,922 | 48,726 | ||||||
| Loss from operations | (42,530 | ) | (42,255 | ) | ||||
| Other income, net | 2,688 | 4,381 | ||||||
| Loss before income taxes | (39,842 | ) | (37,874 | ) | ||||
| Provision for income taxes | (34 | ) | (40 | ) | ||||
| Net loss | $ | (39,876 | ) | $ | (37,914 | ) | ||
| Net loss per common share – basic and diluted | $ | (0.36 | ) | $ | (0.35 | ) | ||
| Weighted average number of common shares outstanding – basic and diluted | 110,301,256 | 108,171,463 | ||||||
| Consolidated Balance Sheets | ||||||||
| (In thousands) | ||||||||
| March 31, | December 31, | |||||||
| 2025 | 2024 | |||||||
| Assets | ||||||||
| Current assets: | ||||||||
| Cash and cash equivalents | $ | 58,432 | $ | 69,530 | ||||
| Marketable securities | 158,292 | 188,387 | ||||||
| Restricted cash | 428 | — | ||||||
| Prepaid expenses and other current assets | 7,778 | 8,426 | ||||||
| Total current assets | 224,930 | 266,343 | ||||||
| Property and equipment, net | 7,539 | 8,102 | ||||||
| Operating lease right-of-use assets | 39,697 | 39,476 | ||||||
| Restricted cash, net of current portion | 2,139 | 2,567 | ||||||
| Other assets | 1 | 4 | ||||||
| Total assets | $ | 274,306 | $ | 316,492 | ||||
| Liabilities and Stockholders' Equity | ||||||||
| Current liabilities: | ||||||||
| Accounts payable | $ | 3,239 | $ | 1,601 | ||||
| Accrued expenses and other current liabilities | 10,374 | 16,497 | ||||||
| Operating lease liabilities | 2,824 | 2,454 | ||||||
| Deferred revenue | 19,480 | 17,618 | ||||||
| Total current liabilities | 35,917 | 38,170 | ||||||
| Operating lease liabilities, net of current portion | 34,122 | 34,039 | ||||||
| Deferred revenue, net of current portion | 37,511 | 44,766 | ||||||
| Total liabilities | 107,550 | 116,975 | ||||||
| Total stockholders’ equity | 166,756 | 199,517 | ||||||
| Total liabilities and stockholders’ equity | $ | 274,306 | $ | 316,492 | ||||
FAQ
What were Tango Therapeutics (TNGX) Q1 2025 financial results?
When will Tango Therapeutics provide clinical updates for TNG462?
What is TNGX's cash runway following Q1 2025 results?
What are the upcoming clinical milestones for Tango Therapeutics (TNGX)?
What is the status of TNGX's partnership with Revolution Medicines?
