Tempest Therapeutics Inc Stock Price, News & Analysis

Tempest Therapeutics (Nasdaq: TPST) announced the acceptance of an abstract for the 2023 ASCO Annual Meeting, scheduled for June 2-6, 2023, in Chicago. The abstract focuses on TPST-1495, an EP2/EP4 prostaglandin receptor dual antagonist.

Presentation Details:

• Title: A Phase 1 study of TPST-1495 as a single agent and in combination with pembrolizumab in patients with advanced solid tumors
• Session Title: Developmental Therapeutics — Molecularly Targeted Agents and Tumor Biology
• Session Date and Time: June 3, 2023; 8:00 a.m. – 11:00 a.m. ET
• Abstract Number: 3107

The abstract will be released on May 25, 2023, at 5:00 p.m. ET on the ASCO website.

Tempest Therapeutics, Inc. (Nasdaq: TPST) recently presented new data from its TPST-1120 and TREX1 programs at the 2023 American Association for Cancer Research Annual Meeting. The findings from TPST-1120, an oral PPAR⍺ antagonist, highlighted biomarker changes linked to drug exposure and response levels in patients undergoing treatment in a Phase 1 trial. Additionally, the TREX1 inhibitor program showcased novel human TREX1 enzyme structures, paving the way for potent inhibitors targeting the STING pathway. The company aims to advance TPST-1120 through multiple oncology indications and initiate human trials for the TREX1 inhibitors. Initial results from ongoing trials are expected soon, indicating promising possibilities for future cancer therapies.

Tempest Therapeutics, Inc. (TPST) reported significant clinical progress in 2022, highlighted by the completion of a Phase 1 study for TPST-1120, indicating a 30% objective response rate in patients unresponsive to traditional therapies. The randomization study in collaboration with Roche for first-line hepatocellular carcinoma (HCC) patients is fully enrolled, with data expected in mid-2023. Financially, Tempest saw a decline in cash reserves to $31.2 million and a net loss of $35.7 million for the year. However, the company anticipates adequate funding through Q2 2024, with ongoing developments in TPST-1495 and a promising TREX1 inhibitor program.

Tempest Therapeutics, Inc. (Nasdaq: TPST) announced a poster presentation by Dr. Nathan Standifer at the Society for Immunotherapy of Cancer (SITC) 2023 Spring Meeting from March 15-17 in Denver, CO, and online. The presentation will detail biomarker findings from the Phase 1 trial of TPST-1120, an oral selective PPAR⍺ antagonist. Key data indicate a link between clinical benefits and changes in fatty acid oxidation and gene expression. The presentation is scheduled for March 16, 2023, from 6:00 to 7:30 p.m. MT, and carries the abstract number 78. Tempest Therapeutics is focused on developing innovative oncology therapeutics that target various tumors.

Tempest Therapeutics, Inc. (Nasdaq: TPST) announced two abstracts accepted for presentation at the 2023 AACR Annual Meeting, scheduled for April 14-19 in Orlando, FL. The posters will cover biomarker data from the Phase 1 trial of TPST-1120, an oral selective PPAR⍺ antagonist, and preclinical data on the TREX1 inhibitor targeting the STING pathway. The first presentation, focusing on lipid and immune-based biomarkers, will occur on April 17, 2023. The second will discuss novel TREX1 inhibitors also on April 17. Tempest's innovative therapies are designed to treat various tumors through immune-mediated mechanisms, pending FDA approval.