Tempest Therapeutics Inc Stock Price, News & Analysis

Tempest Therapeutics (Nasdaq: TPST) presented promising preclinical data on April 8, 2022, regarding its innovative therapeutic programs at the AACR Annual Meeting. The data highlight the anti-tumor efficacy of TPST-1495, a dual antagonist targeting EP2 and EP4 receptors, showing superior tumor growth inhibition compared to single antagonists. Additionally, the TREX1 inhibitors demonstrated significant potential in activating the cGAS/STING pathway, crucial for immune response in tumors. These findings support ongoing clinical studies and underscore Tempest's commitment to developing first-in-class oncology treatments.

Tempest Therapeutics, Inc. (TPST) reported its financial results for 2021, highlighting significant achievements, including a successful merger and collaboration with Roche for TPST-1120. The company ended the year with $51.8 million in cash, a notable increase from $18.8 million in 2020. However, it recorded a net loss of $28.3 million, or $7.47 per share. R&D expenses rose to $17.2 million, indicating increased investment in drug development. Tempest anticipates presenting initial clinical data for TPST-1120 and TPST-1495 by early 2023, showcasing its robust cancer therapeutics pipeline.

Tempest Therapeutics (Nasdaq: TPST) announced its participation in the 32nd Annual Oppenheimer Healthcare Conference on March 17, 2022, at 10:40 a.m. ET. The company is focused on developing first-in-class therapeutics that integrate targeted and immune-mediated mechanisms for various tumors. Its clinical-stage programs, TPST-1120 and TPST-1495, are currently in Phase 1 trials. The company collaborates with F. Hoffmann La Roche for a global Phase 1b/2 study of TPST-1120 in advanced liver cancer patients. More details can be accessed at Tempest's investor site.

Tempest Therapeutics (Nasdaq: TPST) announced two poster presentations at the 2022 AACR virtual annual meeting scheduled for April 8-13, 2022. The presentations feature new preclinical data on TPST-1495, a clinical-stage dual EP2/4 antagonist, and TREX1, a preclinical STING agonist. Key presentations include: TPST-1495 focusing on the dual blockade of PGE2 receptors and TREX1 aimed at activating STING in metastatic disease. Both programs are designed to enhance tumor treatment via targeted and immune-mediated approaches.

Tempest Therapeutics, a clinical-stage oncology company (Nasdaq: TPST), announced its participation in the 11th Annual SVB Leerink Healthcare Conference on February 16, 2022, at 2:20 PM ET. The company is known for developing innovative therapeutics that target tumors and harness immune responses. Presently, it is advancing two main programs, TPST-1120 and TPST-1495, through Phase 1 studies. TPST-1120 is also involved in a global Phase 1b/2 study in combination with atezolizumab and bevacizumab for treating advanced hepatocellular carcinoma. More details are available on their website.

Tempest Therapeutics (Nasdaq: TPST) announced the initiation of patient dosing with TPST-1495 in combination with pembrolizumab. This Phase 1a/1b study aims to optimize dosing schedules for patients with solid tumors. TPST-1495 targets the PGE2 pathway, which is linked to tumor growth and immune suppression. The study will evaluate safety, tolerability, and preliminary anti-tumor activity, focusing on prostaglandin-driven cancers. Tempest is exploring TPST-1495's potential to enhance treatment outcomes when combined with existing therapies.

Tempest Therapeutics (TPST) presented data at the 2021 Society for Immunotherapy of Cancer Annual Meeting, highlighting the dual mechanism of action of its small molecule TPST-1495. The data indicate that TPST-1495 effectively promotes anti-tumor activity in preclinical studies by inhibiting EP2 and EP4 receptors in the prostaglandin pathway. The company plans to initiate combination studies with pembrolizumab and conduct expansion studies focusing on specific cancer types in early 2022. This research underlines TPST-1495's potential in enhancing anti-tumor immunity and improving patient outcomes.

Tempest Therapeutics (TPST) announced the start of a Phase 1b/2 clinical trial for its TPST-1120 therapy in collaboration with Roche, aimed at treating hepatocellular carcinoma (HCC). The company reported a cash position of $59.8 million as of September 30, 2021, up from $18.8 million in December 2020, primarily due to a merger. However, net losses were $8.1 million for Q3 2021, increasing from $5.4 million in Q3 2020. Research and development expenses rose to $4.6 million, reflecting increased operational costs. Tempest anticipates sufficient resources to continue operations into Q2 2023.

Tempest Therapeutics (Nasdaq: TPST) announced participation in two investor conferences this November. The company will present at the Jefferies London Healthcare Conference on November 18, 2021, with an on-demand presentation available at 8:00 a.m. GMT. Additionally, they will engage in a fireside chat at the Piper Sandler 33rd Annual Virtual Healthcare Conference on November 22, 2021, available at 10:00 a.m. ET. Tempest is focused on developing innovative oncology therapeutics, including TPST-1495 and TPST-1120, which are currently in Phase 1 studies.