Welcome to our dedicated page for Entrada Therapeutics news (Ticker: TRDA), a resource for investors and traders seeking the latest updates and insights on Entrada Therapeutics stock.
Entrada Therapeutics, Inc. (Nasdaq: TRDA) is a clinical-stage biopharmaceutical company developing RNA- and protein-based medicines using its Endosomal Escape Vehicle (EEV™) technology. The news flow around Entrada centers on its neuromuscular and ocular pipelines, corporate updates and collaboration activities.
Investors following TRDA news can track detailed updates on the company’s Duchenne muscular dystrophy (DMD) franchise, including the ELEVATE-44-201 and ELEVATE-45-201 global Phase 1/2 multiple ascending dose studies of ENTR-601-44 and ENTR-601-45, and the planned development of ENTR-601-50 and ENTR-601-51. Company announcements describe milestones such as first patient dosing, cohort completion, regulatory authorizations in the U.K. and EU, and expectations for future data readouts.
News releases also highlight Entrada’s expansion into ocular and metabolic diseases, including preclinical progress and the nomination of ENTR-801 as the first ocular clinical candidate for Usher syndrome type 2A. Additional coverage includes updates on the VX-670 collaboration for myotonic dystrophy type 1, quarterly financial results furnished via Form 8-K, inducement equity grants under Nasdaq Listing Rule 5635(c)(4), leadership appointments and participation in healthcare and investor conferences.
By reviewing Entrada Therapeutics news, readers can follow how the company reports on its clinical-stage programs, regulatory interactions, financial position and patient-focused initiatives such as the DREAMS Grant Program. This page aggregates press releases and related disclosures so that followers of TRDA can see how the pipeline and corporate activities evolve over time.
Entrada Therapeutics (Nasdaq: TRDA) presented new data supporting its Duchenne franchise at the 29th Annual Congress of the World Muscle Society. The company shared additional positive data from its completed Phase 1 trial of ENTR-601-44, reinforcing its safety profile and supporting planned Q4 2024 global regulatory filings for a Phase 2 trial. Preclinical data for ENTR-601-45 showed exon skipping and dystrophin production, supporting planned Q4 2024 regulatory filings for a global direct-to-patient Phase 2 trial.
Key highlights include:
- No adverse findings or clinically relevant changes to renal toxicity biomarkers at the highest dose tested for ENTR-601-44
- Statistically significant differences in exon skipping between 6 mg/kg and placebo administrations
- ENTR-601-45 produced robust dose-dependent exon skipping and dystrophin restoration in preclinical models
- Improved skeletal muscle function in an exon 45 skip-amenable DMD mouse model
Entrada Therapeutics, Inc. (Nasdaq: TRDA), a clinical-stage biopharmaceutical company, has promoted Natarajan Sethuraman, PhD, to President of Research and Development. Dr. Sethuraman, previously the Chief Scientific Officer, has been with Entrada since its inception and has played a important role in advancing the company's ENTR-601-44 program into clinical trials. His leadership has been instrumental in building Entrada's pipeline of proprietary intracellular therapeutics.
CEO Dipal Doshi praised Dr. Sethuraman's contributions, highlighting his experience in end-to-end therapeutics development. Dr. Sethuraman expressed excitement about Entrada's approach to intracellular therapeutics and the potential to reach previously inaccessible targets. He joined Entrada in 2017 and has since led global research and clinical development, building an R&D team advancing a portfolio of programs from discovery through clinical development.
āshibio, a clinical-stage biotech company, has appointed Dipal Doshi to its Board of Directors. Doshi, currently CEO of Entrada Therapeutics (NASDAQ: TRDA), brings extensive experience in biopharmaceutical strategy and growth. āshibio, which emerged from stealth mode in June 2024 with $40 million in seed and Series A funding, is developing therapies for bone and connective tissue disorders, including a potential treatment for fibrodysplasia ossificans progressiva (FOP).
Doshi's appointment is expected to contribute significantly to āshibio's next growth phase, leveraging his operational and fundraising expertise. His track record includes advancing Entrada's pipeline, completing private financings, leading its IPO, and executing a major business development collaboration.
Entrada Therapeutics (NASDAQ: TRDA) reported positive Q2 2024 financial results and clinical progress. Key highlights include:
1. Positive Phase 1 data for ENTR-601-44 in DMD, showing dose-dependent plasma and muscle concentration, and exon skipping.
2. Planning for global Phase 2 trials for ENTR-601-44 and ENTR-601-45, with regulatory filings expected in Q4 2024.
3. Completed a $100 million registered direct offering, extending cash runway into 2027.
4. Strong financial position with $470 million in cash and equivalents as of June 30, 2024.
5. Q2 collaboration revenue of $94.7 million, up from $18.2 million in Q2 2023.
6. Net income of $55.0 million for Q2 2024, compared to a net loss of $25.9 million in Q2 2023.
Entrada Therapeutics (Nasdaq: TRDA), a clinical-stage biopharmaceutical company, announced a $100 million registered direct offering. The purchase involves 3,367,003 shares of common stock and pre-funded warrants to purchase an equal amount of common stock. The offering price per share is $14.85, while the pre-funded warrants are priced slightly lower at $14.8499 due to a minimal exercise price of $0.0001 per warrant. The offering is led by a U.S. healthcare investor, two global mutual funds, and Janus Henderson Investors. The funds will support ongoing clinical trials, research, and other corporate needs. The transaction is expected to close around June 25, 2024, subject to customary conditions.
Entrada Therapeutics (Nasdaq: TRDA) has reported positive preliminary data from its Phase 1 trial ENTR-601-44-101 for Duchenne Muscular Dystrophy (DMD). The drug, ENTR-601-44, was well tolerated, showing no serious adverse events. Significant plasma and muscle concentrations were observed, suggesting a clinically meaningful starting dose for Phase 2 trials. The trial included 32 healthy male volunteers, with doses ranging from 0.75 mg/kg to 6 mg/kg. The study demonstrated statistically significant exon skipping in the highest dose cohort, with plans for regulatory filings for Phase 2 trials in Q4 2024.
Entrada Therapeutics, a clinical-stage biopharmaceutical company listed on Nasdaq as TRDA, announces its participation in the Goldman Sachs 45th Annual Global Healthcare Conference. CEO Dipal Doshi will present in a fireside chat scheduled for June 10, 2024, at 4:00 p.m. ET in Miami, FL. The session will be webcast live on the company's website, with a replay available for 90 days.
Entrada Therapeutics (Nasdaq: TRDA), a clinical-stage biopharmaceutical company focused on developing medicines targeting intracellular areas, announced its CEO, Dipal Doshi, will participate in the H.C. Wainwright 2nd Annual BioConnect Investor Conference. The event will occur on May 20, 2024, at NASDAQ in New York, NY, starting at 9:30 a.m. Eastern Time. A live webcast and a 90-day replay will be accessible on the company's website.
Entrada Therapeutics, a clinical-stage biopharmaceutical company, reported its financial results for the first quarter of 2024. The company is focused on developing new medicines targeting intracellular targets. They achieved significant milestones, including dosing for the fourth cohort of a Phase 1 trial for DMD and receiving a $75 million payment from Vertex. With $327 million in cash, the company expects its cash runway to extend through 2026. Collaboration revenue increased to $59.1 million, while R&D expenses rose to $28.6 million.
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