Therapeutic Solutions International Granted Patent on Commercially Available QuadraMune® Nutraceutical for Increasing Natural Killer Cell Immunity in COVID-19 Patients

Rhea-AI Summary

Therapeutic Solutions International, Inc. (TSOI) announces the granting of a patent for QuadraMune® to stimulate natural killer (NK) cell activity in COVID-19 patients. The patent covers immune suppression inhibition, SARS-CoV-2 prevention, brain protection, and T regulatory cell upregulation. The Company aims to address medical needs through innovative therapies and nutraceuticals.

Latest Patent to Complement Issued Claims on Viral Inhibition, Adaptive Immune Stimulation, and Brain Protection/Regeneration

ELK CITY, Idaho--(BUSINESS WIRE)-- Therapeutic Solutions International, Inc. (TSOI), a clinical-stage stem cell and immunotherapy company, announced today the granting of a patent covering the ability of QuadraMune® and similar compositions, to stimulate natural killer (NK) cell activity in patients with COVID-19. NK cells are the first line of defense against viruses and cancers¹.

The Company was previously awarded by the United States Patent and Trademark Office the following QuadraMune® related patents:

1. Patent #11,229,674, covering inhibition of the immune suppressing enzyme indolamine 2,3 dioxygenase². It is published that this enzyme plays a fundamental role in immune suppression by cancer³, as well as numerous viruses including SARS-CoV-2, the causative agent of COVID-19⁴.
2. Patent #11,266,707, “Nutraceuticals for the prevention, inhibition, and treatment of SARS-CoV-2 and associated COVID-19”⁵.
3. Patent #11,504,410, covering use of QuadraMune® and its derivatives for protecting and restoring brain function after neurological damage, including Long COVID⁶.
4. Patent #11759495, covering upregulation of T regulatory cells for suppression of suicidal ideation⁷.

“In addition to this important validation from the USPTO, the fact that the ingredients in QuadraMune® have been reported by institutions such as Johns Hopkins University to suppress SARS-CoV-2 is strongly encouraging,” said Famela Ramos, Vice President of Business Development for the Company.

“Our Company is driven by a desire to address unmet medical needs, whether it is through developing state of the art stem cell and gene therapies, or science-backed nutraceuticals,” said Timothy Dixon, President, and CEO of the Company. “The importance of NK cells in protecting the body against cancer and viruses is well known, the fact that this can be performed using a low-cost nutraceutical approach has implications in both oncology and virology.”

About Therapeutic Solutions International, Inc.

Therapeutic Solutions International is focused on immune modulation for the treatment of several specific diseases. The Company's corporate website is www.therapeuticsolutionsint.com.

1 Cerwenka and Lanier. Natural killer cells, viruses and cancer. Nat Rev Immunol. 2001 Oct;1(1):41-9.

2 https://patents.google.com/patent/US11229674B1/

3 Ricuitti et al. Targeting indoleamine-2,3-dioxygenase in cancer: Scientific rationale and clinical evidence. Pharmacol Ther. 2019 Apr:196:105-116.

4 Guo et al. Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19. J Pathol. 2022 Mar;256(3):256-261.

5 https://patents.google.com/patent/US11266707B2/

6 https://patents.google.com/patent/US11504410B2

7 https://patents.google.com/patent/US11759495B2/

8 Johns Hopkins University Publishes Efficacy of QuadraMune™ Ingredient Sulforaphane at Inhibiting Coronavirus in Laboratory Studies | BioSpace

View source version on businesswire.com: https://www.businesswire.com/news/home/20240304286293/en/

Timothy G. Dixon

ir@tsoimail.com

Source: Therapeutic Solutions International, Inc.

What is the latest patent granted to Therapeutic Solutions International, Inc. (TSOI)?

The latest patent covers the ability of QuadraMune® to stimulate natural killer (NK) cell activity in patients with COVID-19.

What does the patent #11,229,674 cover?

Patent #11,229,674 covers the inhibition of the immune suppressing enzyme indolamine 2,3 dioxygenase.

What is the significance of QuadraMune® according to the press release?

QuadraMune® ingredients have been reported to suppress SARS-CoV-2 and stimulate NK cells, crucial in fighting viruses and cancers.

Who mentioned the importance of NK cells in the press release?

The President and CEO of the Company, Timothy Dixon, emphasized the importance of NK cells in protecting against cancer and viruses.

What is the focus of Therapeutic Solutions International, Inc. (TSOI) according to the press release?

The Company is focused on addressing unmet medical needs through stem cell therapies, gene therapies, and nutraceuticals.