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Umoja Biopharma has announced a groundbreaking publication in the journal Blood, showcasing the first successful generation of in vivo CAR T-cells in a non-human primate (NHP) model. The data validate their VivoVec platform, demonstrating its potential to transform CAR T-cell therapies. Results indicated that VivoVec lentiviral particles could generate CAR+ T-cells targeting CD20 without lymphodepleting chemotherapy, leading to complete B-cell depletion for over 10 weeks. Key findings highlight the enhanced antitumor functionality of CAR T-cells generated via VivoVec particles, featuring a multidomain fusion protein. Umoja plans to initiate human trials in the latter half of 2024, aiming to improve treatment accessibility and effectiveness in oncology and autoimmunity.