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Vigil Neuroscience, Inc. - VIGL STOCK NEWS

Welcome to our dedicated page for Vigil Neuroscience news (Ticker: VIGL), a resource for investors and traders seeking the latest updates and insights on Vigil Neuroscience stock.

Vigil Neuroscience, Inc. (VIGL) is a pioneering biopharmaceutical company dedicated to developing microglia-focused therapeutics. These specialized treatments aim to treat both rare and common neurodegenerative diseases by restoring the vigilance of microglia, the sentinel cells of the brain’s immune system. Vigil Neuroscience leverages modern neuroscience drug development tools to create precision-based therapies that significantly improve the quality of life for patients and their families.

One of the company's key initiatives is the clinical development of iluzanebart, which is currently in a Phase 2 Proof of Concept (PoC) trial named IGNITE. This is the first-ever interventional trial targeting Adult-onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP) patients, marking a critical advancement in the treatment landscape for this rare disease. In addition, the company is working on VG-3927, an orally available small molecule TREM2 agonist designed to treat more common neurodegenerative diseases associated with microglial dysfunction.

Vigil Neuroscience has also made notable strides in community engagement and support. Their comprehensive patient support initiatives include the ALSPAware program, which offers no-cost genetic testing and counseling. This program aims to reduce the barriers to accurate diagnosis and enable better disease management for ALSP patients.

Recent research presented by the company has revealed significant findings on the diagnostic challenges faced by the ALSP community. For instance, a retrospective analysis disclosed that only 24.7 percent of ALSP patients received an accurate initial diagnosis, with many being misdiagnosed with multiple sclerosis (MS) due to similar early symptoms. Vigil Neuroscience's ongoing research aims to provide better diagnostic tools and treatment options, thereby improving the overall patient journey.

Additionally, Vigil Neuroscience has been actively presenting its latest findings and achievements at various conferences. Recent presentations have highlighted the potential of VG-3927 to treat neurodegenerative diseases like Alzheimer's Disease (AD), showcasing its neuroprotective profile and ability to favorably modulate microglia activation.

As Vigil Neuroscience continues to advance its clinical programs and expand its therapeutic pipeline, it remains committed to delivering innovative solutions that address the unmet needs of patients suffering from neurodegenerative diseases.

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Vigil Neuroscience, Inc. presented a poster at the 2024 ACTRIMS Forum highlighting the clinical overlap of ALSP and multiple sclerosis, emphasizing the importance of genetic testing. The analysis revealed challenges in accurate diagnosis, with only 24.7% initially diagnosed correctly. Barriers to genetic testing include uncertainties, fear of results, financial impact, and care management challenges.
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Vigil Neuroscience, Inc. announced the participation of its President and CEO, Ivana Magovčević-Liebisch, and Chief Science Officer, David Gray, in a fireside chat at the Guggenheim 6th Annual Biotechnology Conference. The webcast will be available on the company's website, and an archived webcast will be accessible for approximately 90 days after the presentation.
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Vigil Neuroscience, Inc. (Nasdaq: VIGL) extends projected cash runway into second half of 2025. The company is on track to report interim Phase 1 data for VG-3927 in healthy volunteers in mid-2024 and Phase 2 results from IGNITE clinical trial evaluating iluzanebart in Q3 2024. The company presented at J.P. Morgan Healthcare Conference on January 11, 2024.
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Vigil Neuroscience, Inc. (VIGL) to participate in fireside chat at Evercore ISI 6th Annual HealthCONx Conference
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Vigil Neuroscience, Inc. (Nasdaq: VIGL) announced positive interim data from the Company’s Phase 2 IGNITE proof-of-concept clinical trial in patients with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). The interim data demonstrated favorable safety and tolerability of iluzanebart, clear CNS target engagement, and downstream pharmacological activity at 20 mg/kg, with directionally supportive changes in individual patients at 6 months on MRI and NfL biomarkers. The Company expects to report Phase 2 IGNITE results from all patients in 20 mg/kg and 40 mg/kg cohorts at 6 months in the third quarter of 2024. Vigil will host a webinar to discuss the Phase 2 IGNITE interim data today at 4:30 p.m. ET.
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Vigil Neuroscience, Inc. announced financial results for the third quarter, with a cash position of $133.6 million as of September 30, 2023. They provided updates on their ongoing clinical trials for VGL101 in ALSP and VG-3927 in Alzheimer's disease, including interim data from the IGNITE Phase 2 clinical trial of VGL101 on track for this quarter and the first participant dosed in the Phase 1 study of VG-3927.
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Vigil Neuroscience announces dosing of first participant in Phase 1 clinical trial for potential Alzheimer's treatment
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Vigil Neuroscience to participate in fireside chat at Jefferies Inaugural Biotech CNS/Neuro Summit
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Vigil Neuroscience receives positive opinion for orphan drug designation for VGL101 in EU for the treatment of CSF1R-related leukoencephalopathy
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Vigil Neuroscience announces positive Phase 1 data analysis for VGL101, on track to report interim data from IGNITE trial in Q4 2023
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FAQ

What is the current stock price of Vigil Neuroscience (VIGL)?

The current stock price of Vigil Neuroscience (VIGL) is $3.775 as of October 31, 2024.

What is the market cap of Vigil Neuroscience (VIGL)?

The market cap of Vigil Neuroscience (VIGL) is approximately 149.9M.

What is the primary focus of Vigil Neuroscience, Inc.?

Vigil Neuroscience focuses on developing therapeutics that target microglia to treat rare and common neurodegenerative diseases.

What is iluzanebart?

Iluzanebart is a clinical candidate being studied in a Phase 2 PoC trial called IGNITE, targeting patients with Adult-onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP).

What is VG-3927?

VG-3927 is an orally available small molecule TREM2 agonist under development for treating common neurodegenerative diseases associated with microglial dysfunction.

What is the ALSPAware program?

The ALSPAware program offers no-cost genetic testing and counseling to facilitate accurate diagnosis and better disease management for ALSP patients.

What recent findings has Vigil Neuroscience presented?

Vigil Neuroscience has presented data on diagnostic challenges in ALSP and the potential of VG-3927 to treat neurodegenerative diseases like Alzheimer's Disease.

How does Vigil Neuroscience contribute to the neurodegenerative disease community?

Vigil Neuroscience contributes through clinical research, patient support programs, and the development of innovative therapies targeting microglial dysfunction.

What is the IGNITE trial?

The IGNITE trial is a Phase 2 PoC clinical study investigating iluzanebart for treating ALSP patients.

Why is microglia important in neurodegenerative diseases?

Microglia are the sentinel cells of the brain's immune system, and their dysfunction is linked to various neurodegenerative conditions. Restoring their vigilance can mitigate disease progression.

What challenges do ALSP patients face in terms of diagnosis?

ALSP patients often face misdiagnosis, with multiple sclerosis (MS) being a common incorrect diagnosis due to similar early symptoms.

Who can I contact for investor and media inquiries?

For investor inquiries, contact Leah Gibson, Vice President of Investor Relations & Corporate Communications at lgibson@vigilneuro.com. For media inquiries, contact Megan McGrath at MacDougall Advisors via email at mmcgrath@macdougall.bio.

Vigil Neuroscience, Inc.

Nasdaq:VIGL

VIGL Rankings

VIGL Stock Data

149.87M
39.65M
21.27%
80.15%
1.29%
Biotechnology
Biological Products, (no Disgnostic Substances)
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United States of America
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