Viking Therapeutics Presents Data from its 13-Week Phase 2 VENTURE-Oral Dosing Trial of VK2735 at European Congress on Obesity (ECO) 2026

Rhea-AI Summary

Viking Therapeutics (NASDAQ: VKTX) presented 13-week Phase 2 VENTURE-Oral/Venture-2 data for once-daily oral VK2735 in adults with obesity at ECO 2026.

VK2735 produced statistically significant, dose-dependent weight loss up to 12.2% (26.6 lbs), with early, progressive reductions from Week 1 and a generally favorable tolerability profile. A related Phase 3 subcutaneous study (VANQUISH-1) design was also highlighted.

AI-generated analysis. Not financial advice.

Positive

• Mean body-weight reduction up to 12.2% (26.6 lbs) at Week 13 on highest VK2735 dose
• Placebo-adjusted mean percent weight change up to -10.9% at 13 weeks
• Up to 97% of VK2735 subjects achieved ≥5% weight loss vs 10% on placebo
• Up to 80% of VK2735 subjects achieved ≥10% weight loss vs 5% on placebo
• Drug-related TEAEs were 98% mild or moderate, typically resolving with continued dosing
• Statistically significant weight loss observed from Week 1 at doses above 15 mg

Negative

• Gastrointestinal-related treatment-emergent adverse events were the most common TEAEs with VK2735
• VENTURE-Oral/Venture-2 data cover only a 13-week treatment period
• VK2735 remains in clinical development; long-term efficacy and safety await Phase 3 results

Key Figures

Max weight loss: 12.2% (26.6 lbs) ≥5% weight loss (VK2735): Up to 97% ≥10% weight loss (VK2735): Up to 80% +5 more

8 metrics

Max weight loss 12.2% (26.6 lbs) Mean reduction from baseline at Week 13, highest oral VK2735 dose

≥5% weight loss (VK2735) Up to 97% Participants on oral VK2735 achieving ≥5% loss at Week 13

≥10% weight loss (VK2735) Up to 80% Participants on oral VK2735 achieving ≥10% loss at Week 13

≥5% weight loss (placebo) 10% Placebo participants achieving ≥5% weight loss

≥10% weight loss (placebo) 5% Placebo participants achieving ≥10% weight loss

Average BMI 37 Baseline BMI of VENTURE-Oral study population

Average age 51 years Baseline age of VENTURE-Oral study population

Pre-diabetes prevalence 54% VENTURE-Oral participants with pre-diabetes at baseline

Market Reality Check

Price: $31.72 Vol: Volume 1,950,994 is below...

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$31.72 Last Close

Volume Volume 1,950,994 is below the 20-day average of 2,369,903 (relative volume 0.82). normal

Technical Trading below 200-day MA of 32.74 with price at 31.72, still under longer-term trend.

Peers on Argus

VKTX was up 1.24% while close peers were mixed: IMVT up 0.41%, XENE, CRNX, SLNO,...

VKTX was up 1.24% while close peers were mixed: IMVT up 0.41%, XENE, CRNX, SLNO, SRRK modestly negative, indicating a stock-specific reaction rather than a broad biotech move.

Previous Clinical trial Reports

5 past events · Latest: Mar 26 (Positive)

Same Type Pattern 5 events

Date	Event	Sentiment	Move	Catalyst
Mar 26	Phase 3 enrollment	Positive	+3.2%	Completion of enrollment in Phase 3 VANQUISH-2 trial of VK2735.
Jan 12	Phase 2 results	Positive	-0.7%	Publication of Phase 2 VENTURE subcutaneous VK2735 results showing up to 14.7% weight loss.
Jan 08	Maintenance study enroll	Positive	-2.3%	Completion of enrollment in Phase 1 maintenance dosing trial of VK2735 in obesity.
Nov 19	Phase 3 enrollment	Positive	-4.6%	Completion of enrollment in Phase 3 VANQUISH-1 obesity trial ahead of schedule.
Nov 06	Clinical data update	Positive	+2.2%	Presentation of VK2735 Phase 2 data at ObesityWeek 2025 with strong metabolic outcomes.

Pattern Detected

Clinical trial updates on VK2735 have produced mixed stock reactions, with an average same-tag move of -0.44% and several instances of negative reactions to seemingly positive data.

Recent Company History

Over the past several months, Viking has steadily advanced VK2735 through late-stage obesity development. In Nov 2025, it completed Phase 3 VANQUISH-1 enrollment (~4,650 adults). Subsequent updates in Jan–Mar 2026 covered completion of a maintenance study, publication of Phase 2 VENTURE results showing up to 14.7% weight loss, and full enrollment of Phase 3 VANQUISH-2 (~1,000 adults). This ECO 2026 poster adds detailed 13-week oral VK2735 data, extending the VK2735 efficacy and tolerability narrative.

Historical Comparison

-0.4% avg move · Past VK2735 clinical-trial headlines have averaged a -0.44% move, with mixed upside and downside. Th...

clinical trial

-0.4%

Average Historical Move clinical trial

Past VK2735 clinical-trial headlines have averaged a -0.44% move, with mixed upside and downside. This ECO 2026 oral VK2735 data fits into a pattern of substantial clinical progress but uneven immediate price reactions.

Clinical updates trace a path from Phase 2 VENTURE efficacy, through Phase 3 VANQUISH-1 and VANQUISH-2 enrollment completion, to detailed oral VK2735 data now showcased at ECO 2026.

Market Pulse Summary

This announcement provides detailed Phase 2 oral VK2735 data, showing up to 12.2% mean weight loss a...

Analysis

This announcement provides detailed Phase 2 oral VK2735 data, showing up to 12.2% mean weight loss at 13 weeks, high proportions achieving ≥5% and ≥10% loss, and mainly mild-to-moderate TEAEs. It complements earlier subcutaneous VENTURE and VANQUISH updates, underscoring a broad obesity franchise. Investors may watch for Phase 3 oral trial initiation, longer-duration outcomes, and how safety, efficacy, and dosing convenience compare across the competitive landscape.

Key Terms

glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), treatment-emergent adverse events (TEAEs), BMI, +3 more

7 terms

glucagon-like peptide 1 (GLP-1) medical

"VK2735 is a dual agonist of the glucagon-like peptide 1 (GLP-1)…"

A naturally occurring hormone that signals the body to release insulin, slow stomach emptying, and reduce appetite, acting like a thermostat that helps control blood sugar and hunger. It matters to investors because medicines that mimic or boost this hormone are a major and growing class of treatments for diabetes and obesity, driving drug sales, regulatory decisions, and company valuations in the health sector.

glucose-dependent insulinotropic polypeptide (GIP) medical

"…and glucose-dependent insulinotropic polypeptide (GIP) receptors…"

Glucose-dependent insulinotropic polypeptide (GIP) is a hormone released by the gut after eating that tells the pancreas to release insulin only when blood sugar is high, and it also influences appetite and fat storage. Investors watch GIP because drugs that mimic or block its action are a major focus for diabetes and obesity treatments; successful clinical results or regulatory setbacks can materially affect a drugmaker’s prospects and market value.

treatment-emergent adverse events (TEAEs) medical

"The vast majority of treatment-emergent adverse events (TEAEs) were mild…"

Adverse events that first appear or worsen after a patient starts a medical treatment; they are the new or intensified negative effects linked in time to taking the drug or therapy. Investors care because the number and severity of these events shape regulators’ decisions, drug labeling, patient uptake and potential legal or cost risks—think of them like customer complaints that can slow sales, trigger recalls, or change a product’s value.

BMI medical

"…average BMI of 37 and average age of 51 years."

Body mass index (BMI) is a simple number calculated from a person’s weight and height that classifies them as underweight, normal weight, overweight, or obese; think of it as a quick ratio like miles per gallon for body size. Investors watch BMI because shifts in population averages influence demand for healthcare services, drugs, medical devices, and insurance costs, and they can signal longer-term trends in workforce health and public spending.

p-value technical

"p-value vs. baseline 5 | - | 0.0057"

A p-value is a number that helps determine how likely it is that a result or pattern happened by chance rather than because of a real effect. For investors, a low p-value suggests that the findings in a study or analysis are probably meaningful and not just random noise—like noticing a pattern in coin flips that’s unlikely to occur by chance. This helps in assessing the reliability of information used to make financial decisions.

Phase 2 medical

"…Phase 2 VENTURE-Oral Dosing trial evaluating the oral tablet…"

Phase 2 is the mid-stage clinical trial where a new drug or treatment is tested in a larger group of patients to see if it works and to keep checking safety after initial human testing. Think of it as a field test that proves whether a product actually delivers its promised benefit. Investors watch Phase 2 closely because its results strongly influence a medicine’s chances of reaching the market, the size of its potential sales, and the company’s valuation.

Phase 3 medical

"…ongoing Phase 3 VANQUISH-1 study of VK2735 in adults with obesity…"

Phase 3 is the late-stage clinical testing step for a new drug or medical treatment, where the product is given to large groups of patients to confirm effectiveness, monitor side effects, and compare it to standard care. Successful Phase 3 results are often the final scientific hurdle before regulators decide on approval and market launch—like passing a final exam before graduation—and can sharply change a company's valuation and future revenue prospects.

AI-generated analysis. Not financial advice.

Oral VK2735 demonstrated early, progressive weight loss from Week 1 through Week 13 without a plateau

Dose-dependent weight loss observed across all VK2735 cohorts, with the highest dose achieving a mean reduction of up to 12.2% (26.6 lbs) from baseline at Week 13

Baseline characteristics in the ongoing Phase 3 VANQUISH-1 study of VK2735 in adults with obesity were also presented in a second poster at the conference

SAN DIEGO, May 12, 2026 /PRNewswire/ -- Viking Therapeutics, Inc. ("Viking") (NASDAQ: VKTX), a clinical-stage biopharmaceutical company focused on the development of novel therapies for metabolic and endocrine disorders, today presented additional data from its Phase 2 VENTURE-Oral Dosing trial evaluating the oral tablet formulation of VK2735 at the European Congress on Obesity (ECO) in Istanbul, Türkiye. VK2735 is a dual agonist of the glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors, in development with subcutaneous and oral formulations for the potential treatment of various metabolic disorders.

The poster presented today at ECO 2026 highlighted key findings from previously reported trial data, including mean change from baseline in body weight throughout the 13-week treatment period and additional safety and tolerability data, for the Phase 2 study of orally administered VK2735.  Participants receiving once-daily oral VK2735 demonstrated statistically significant, dose-dependent weight loss from baseline of up to 12.2% (26.6 lbs) at 13 weeks across all dose cohorts.  Compared with placebo, doses >15 mg demonstrated dose-dependent and progressive weight loss starting early in treatment and continuing through the 13-week treatment window, with no plateau.  Up to 97% of VK2735-treated participants achieved ≥5% weight loss, and up to 80% achieved ≥10%, compared with 10% and 5%, respectively, for placebo.  VK2735 was well tolerated, with the vast majority of treatment-emergent adverse events (TEAEs) reported as mild or moderate in severity.  These events typically occurred early in treatment and resolved with continued dosing.  The study population was similar to patients typically encountered in clinical practice, with an average BMI of 37 and average age of 51 years.  Similar to patients seen in clinical practice, there was a high prevalence of cardiometabolic risk factors, including pre-diabetes (54%).  Across all dose cohorts, the male-to-female ratio ranged from 15:85 to 45:55. 

"The Phase 2a VENTURE-Oral Dosing study results provide important data to inform the design of our upcoming oral Phase 3 registration studies.  We observed compelling efficacy, a clear dose-response, and an encouraging tolerability profile through the 13-week treatment period in the study.  All treated cohorts demonstrated statistically significant weight loss from baseline, and the full dataset presented at ECO provides a detailed picture of response over time," said Brian Lian, Ph.D., chief executive officer of Viking Therapeutics.  "We are excited to move oral VK2735 into Phase 3 development as we believe it has the potential to become the first oral dual agonist of the GLP-1 and GIP receptors to reach the market.  Together with the subcutaneous formulation, currently in the ongoing Phase 3 VANQUISH registration program, the oral tablet formulation represents a potentially differentiated treatment option by enabling patients to transition from injection to oral administration using the same active therapeutic agent.  We look forward to initiating Phase 3 trials with the tablet later this year."

"From a clinical perspective, the early onset and continued progression of weight loss without plateau over 13 weeks is particularly compelling," said Parke Joseph Hedges, M.D., FACOG, Flourish Research, San Antonio, TX, a lead investigator in the VENTURE-Oral study.  "We're seeing meaningful reductions emerge as early as Week 1 and continue across all dosing levels, alongside a tolerability profile that is manageable and consistent with dual agonist GLP-1/GIP receptors. The availability of a once-daily oral option that delivers this level of efficacy could represent an important and more accessible treatment option for patients for initial treatment as well as maintenance."

Highlights from Viking's poster titled Treatment with Oral VK2735 Results in Significant Weight Loss: The Randomized, Placebo-Controlled, Dose-Finding VENTURE-2 Study include:

• Early and progressive weight loss.  Patients receiving VK2735 experienced statistically significant reductions in body weight compared with placebo, beginning as early as Week 1 at all doses greater than 15 mg, with continuous and progressive weight loss observed throughout the 13-week treatment period.
• No plateau observed.  Weight loss trajectories demonstrate continued downward trends across all active dose levels through Week 13, supporting the potential for continued weight reduction with longer-duration treatment.
• Dose-dependent efficacy.  Weight loss increased with escalating doses of VK2735, with the highest dose achieving a mean reduction of up to 12.2% of body weight from baseline at Week 13.
• Favorable tolerability profile.  Among subjects receiving VK2735, the majority (98%) of reported drug-related TEAEs were categorized as mild or moderate in severity. Gastrointestinal-related events were the most commonly observed TEAEs and were consistent with dual agonist GLP-1/GIP receptors, typically occurring early in treatment and subsiding with continued dosing.
• Progressive titration enabled tolerability.  Dose escalation in 30 mg increments enabled rapid progression to higher dose levels with an encouraging tolerability profile, and gastrointestinal events diminished over time.  Lower starting doses and longer titration windows may further improve tolerability.

Change in Body Weight Following 13 Weeks of Daily Dosing with Oral VK2735

Dose Level1,2	Placebo (n=40)	VK2735 15 mg (n=40)	VK2735 30 mg (n=40)	VK2735 60 mg (n=38)	VK2735 90 mg (n=39)	VK2735 120 mg (n=39)
Mean baseline body weight (kg)3	105.2 kg	99.0 kg	102.9 kg	102.8 kg	103.4 kg	101.9 kg
Mean change from baseline body weight4,5	-1.3 kg	-2.2 kg	-7.1 kg	-8.8 kg	-11.5 kg	-12.1 kg
Mean percent change from baseline4,5	-1.3 %	-2.3 %	-7.0 %	-8.7 %	-11.1 %	-12.2 %
p-value vs. baseline5	-	0.0057	<0.0001	<0.0001	<0.0001	<0.0001
Placebo-adjusted mean percent change from baseline4,5	-	-1.0 %	-5.7 %	-7.4 %	-9.8 %	-10.9 %
p-value vs. placebo5	-	-	<0.0001	<0.0001	<0.0001	<0.0001
Percent reporting ≥ 10% weight loss	5 %	8 %	35 %	40 %	59 %	80 %
p-value vs. placebo6	-	-	<0.01	0.0017	< 0.0001	<0.0001

Notes:  1) Efficacy population, includes all randomized patients who received at least one dose of study drug and had a valid baseline and post-baseline body weight assessment. 2) Participants treated with VK2735 were titrated to final doses as indicated: 15 mg cohort = 15 mg x 13 weeks; 30 mg cohort = 30 mg x 13 weeks; 60 mg cohort = 30 mg x 2 weeks, 60 mg x 11 weeks; 90 mg cohort = 30 mg x 2 weeks, 60 mg x 2 weeks, 90 mg x 9 weeks; 120 mg cohort = 30 mg x 2 weeks, 60 mg x 2 weeks, 90 mg x 2 weeks, 120 mg x 7 weeks. 3) All enrolled participants were required to have baseline BMI ≥30 kg/m2 or BMI≥27 kg/m2 with at least one weight-related comorbid condition. 4) Least squares mean. 5) Two-sided t-test using mixed model for repeated measures. 6) Logistic regression model with treatment as factor and baseline weight as covariate.

Poster Presentation Details:

Publication Number: PO4.260

Title: Treatment with Oral VK2735 Results in Significant Weight Loss: The Randomized, Placebo-Controlled, Dose-Finding VENTURE-2 Study

Presented by: Karen Modesto, M.D., Vice President, Clinical Development

Date/Time: On display May 12-15, with poster networking session on May 14 from 18 – 19:15 Turkish Time

Location: Poster area at Level B5, Istanbul Congress Center

Viking also presented a second poster at ECO today highlighting the design and enrollment demographics of the ongoing Phase 3 VANQUISH-1 study of subcutaneous VK2735 in adults with obesity or who are overweight and have at least one weight-related comorbidity.

Poster Presentation Details:

Publication Number: PO4.278

Title: VANQUISH-1: Phase 3 Trial With Enrollment of Diverse Population to Test Efficacy of Subcutaneous VK2735 in Adult Participants with Obesity or Overweight with Weight Related Comorbidities

Presented by: Karen Modesto, M.D., Vice President, Clinical Development

Date/Time: On display May 12-15, with poster networking session on May 14 from 18 – 19:15 Turkish Time

Location: Poster area at Level B5, Istanbul Congress Center

Copies of these poster presentations are available in the Publications section of Viking's website at www.vikingtherapeutics.com/pipeline/publications/.

About the Phase 2 VENTURE-Oral Trial
The Phase 2 VENTURE-Oral Dosing Trial was a randomized, double-blind, placebo-controlled multicenter study designed to evaluate the safety, tolerability, pharmacokinetics, and weight loss efficacy of VK2735 dosed as an oral tablet once daily for 13 weeks. The trial enrolled 280 adults who are obese (BMI ≥30 kg/m²), or adults who are overweight (BMI ≥27 kg/m²) with at least one weight-related co-morbid condition. Enrolled patients were evenly randomized to one of six dosing arms or placebo. The primary endpoint of the study was the percent change in body weight from baseline after 13 weeks of treatment, while secondary and exploratory endpoints evaluated a range of additional safety and efficacy measures.

About VK2735
VK2735 is a novel dual agonist of the glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors in development for the treatment of metabolic disorders, including obesity. The compound is being evaluated in both oral and subcutaneous formulations.

About GLP-1 and Dual GLP-1/GIP Agonists
Activation of the glucagon-like peptide 1 (GLP-1) receptor has been shown to decrease glucose, reduce appetite, lower body weight, and improve insulin sensitivity in patients with type 2 diabetes, obesity, or both. Semaglutide is a GLP-1 receptor agonist that has been approved by the U.S. Food and Drug Administration and is currently marketed in various dosage strengths and forms as Ozempic®, Rybelsus®, and Wegovy®. More recently, research efforts have explored the potential co-activation of the glucose-dependent insulinotropic peptide (GIP) receptor as a means of enhancing the therapeutic benefits of GLP-1 receptor activation. Tirzepatide is a dual GLP-1/GIP receptor agonist that has been approved by the U.S. Food and Drug Administration and is currently marketed in various dosage strengths and forms as Mounjaro® and Zepbound®.

About Viking Therapeutics
Viking Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on the development of novel first-in-class or best-in-class therapies for the treatment of metabolic and endocrine disorders. Viking's research and development activities leverage its expertise in metabolism to develop innovative therapeutics designed to improve patients' lives. Viking's clinical programs include VK2735, a novel dual agonist of the glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors for the potential treatment of various metabolic disorders. The company is evaluating its subcutaneous formulation of VK2735 in a Phase 3 obesity program that includes two Phase 3 clinical trials (VANQUISH-1 and VANQUISH-2). Data from a Phase 1 and a Phase 2 trial evaluating subcutaneous VK2735 demonstrated an encouraging safety and tolerability profile as well as positive signs of clinical benefit. Concurrently, the company is evaluating an oral formulation of VK2735 in a Phase 2 trial in obesity. Viking is also developing VK2809, a novel, orally available, small molecule selective thyroid hormone receptor beta agonist for the treatment of lipid and metabolic disorders. The compound successfully achieved both the primary and secondary endpoints in a Phase 2b study for the treatment of biopsy-confirmed non-alcoholic steatohepatitis (NASH) and fibrosis. In a Phase 2a trial for the treatment of non-alcoholic fatty liver disease (NAFLD) and elevated LDL-C, patients who received VK2809 demonstrated statistically significant reductions in LDL-C and liver fat content compared with patients who received placebo. The company's newest program is evaluating a series of internally developed dual amylin and calcitonin receptor agonists (or DACRAs) for the treatment of obesity and other metabolic disorders. In the rare disease space, Viking is developing VK0214, a novel, orally available, small molecule selective thyroid hormone receptor beta agonist for the potential treatment of X-linked adrenoleukodystrophy (X-ALD). In a Phase 1b clinical trial in patients with the adrenomyeloneuropathy (AMN) form of X-ALD, VK0214 was shown to be safe and well-tolerated, while driving significant reductions in plasma levels of very long-chain fatty acids (VLCFAs) and other lipids, as compared to placebo.

For more information about Viking Therapeutics, please visit www.vikingtherapeutics.com.

Forward-Looking Statements
This press release contains forward-looking statements regarding Viking Therapeutics, Inc., under the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995, including statements about Viking's expectations regarding its clinical and preclinical development programs, anticipated timing for reporting clinical data and cash resources.  Forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially and adversely and reported results should not be considered as an indication of future performance. These risks and uncertainties include, but are not limited to: risks associated with the success, cost and timing of Viking's product candidate development activities and clinical trials, including those for VK2735, VK0214, VK2809, and the company's other incretin and other receptor agonists; risks that prior clinical and preclinical results may not be replicated; risks regarding regulatory requirements; and other risks that are described in Viking's most recent periodic reports filed with the Securities and Exchange Commission including Viking's Annual Report on Form 10-K for the year ended December 31, 2024, and subsequent Quarterly Reports on Form 10-Q, including the risk factors set forth in those filings.  These forward-looking statements speak only as of the date hereof.  Viking disclaims any obligation to update these forward-looking statements except as required by law.

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SOURCE Viking Therapeutics, Inc.

FAQ

What did Viking Therapeutics (NASDAQ: VKTX) report about oral VK2735 at ECO 2026?

Viking reported Phase 2 VENTURE-Oral data showing statistically significant, dose-dependent weight loss over 13 weeks with once-daily oral VK2735. According to Viking, reductions began as early as Week 1 at doses above 15 mg and continued without plateau through Week 13.

How much weight loss did VKTX’s oral VK2735 achieve in the 13-week Phase 2 VENTURE-Oral trial?

According to Viking, the highest oral VK2735 dose produced a mean body-weight reduction of up to 12.2% (26.6 lbs) at Week 13. Placebo-adjusted mean percent change reached up to -10.9%, with progressive, dose-dependent effects across escalating dose cohorts.

What proportion of patients achieved at least 5% and 10% weight loss with oral VK2735 in the VKTX Phase 2 study?

According to Viking, up to 97% of VK2735-treated participants achieved ≥5% weight loss and up to 80% achieved ≥10%. In comparison, 10% and 5% of placebo participants reached those thresholds, respectively, highlighting substantial separation from placebo at 13 weeks.

What was the safety and tolerability profile of oral VK2735 in Viking Therapeutics’ VENTURE-Oral trial?

According to Viking, VK2735 was generally well tolerated, with 98% of drug-related treatment-emergent adverse events rated mild or moderate. Gastrointestinal events were the most common, tended to occur early in treatment, and typically subsided with continued dosing and titration.

How quickly did weight loss start with VKTX’s oral VK2735 in the Phase 2 VENTURE-Oral/Venture-2 study?

According to Viking, statistically significant weight loss versus placebo began as early as Week 1 at all doses greater than 15 mg. Weight reduction continued progressively through the 13-week treatment period, with no plateau observed across the evaluated oral dose levels.

What is Viking Therapeutics’ VANQUISH-1 Phase 3 trial of subcutaneous VK2735, and how does it relate to VKTX’s oral program?

VANQUISH-1 is an ongoing Phase 3 trial testing subcutaneous VK2735 in adults with obesity or overweight plus comorbidities. According to Viking, the oral tablet shares the same active agent, potentially allowing patients to transition from injectable to oral therapy if both formulations succeed.