Welcome to our dedicated page for Verastem news (Ticker: VSTM), a resource for investors and traders seeking the latest updates and insights on Verastem stock.
Verastem Oncology develops and commercializes oncology medicines for RAS/MAPK pathway-driven cancers. The company markets AVMAPKI FAKZYNJA CO-PACK in the U.S. for KRAS-mutated recurrent low-grade serous ovarian cancer and reports commercial updates, product revenue, and medical-conference data for the avutometinib and defactinib combination.
Recurring VSTM news also covers the company’s small-molecule pipeline, including RAF/MEK inhibition, FAK inhibition, and VS-7375, an oral KRAS G12D inhibitor studied in KRAS G12D-mutant solid tumors. Company updates commonly include clinical-trial analyses from RAMP studies, preclinical research presentations, FDA-related treatment context, patient advocacy resources for LGSOC, executive and employee equity grants, and quarterly financial results.
Verastem Oncology (Nasdaq: VSTM) announced its participation in two upcoming virtual investor conferences. The H.C. Wainwright BIOCONNECT Virtual Conference will feature a fireside chat available on-demand starting January 10, 2022, at 7:00 a.m. ET. Additionally, the B. Riley Oncology Conference will host a fireside chat on January 28, 2022, at 9:30 a.m. ET. Webcasts of both chats will be accessible through the investor section of the company's website, www.verastem.com, along with archived presentations following each event.
Mirati Therapeutics and Verastem Oncology announced a clinical collaboration to assess the combination of Mirati's adagrasib, a KRASG12C inhibitor, with Verastem's VS-6766, a RAF/MEK inhibitor, in treating KRASG12C-mutant non-small cell lung cancer (NSCLC). This multi-center trial aims to evaluate the maximum tolerated and recommended doses, alongside safety and efficacy in patients resistant to existing treatments. Both companies are optimistic about improved outcomes for patients facing high unmet needs in NSCLC.
Mirati Therapeutics (Nasdaq:MRTX) and Verastem Oncology (Nasdaq:VSTM) announced a collaboration to evaluate the combination of Mirati's adagrasib and Verastem's VS-6766 in treating KRASG12C-mutant non-small cell lung cancer (NSCLC). The Phase 1/2 trial aims to determine the maximum tolerated dose and assess safety and efficacy in patients who have progressed on a KRASG12C inhibitor. The collaboration targets unmet needs in NSCLC treatments, potentially enhancing patient outcomes.
Verastem Oncology (NASDAQ: VSTM) announced its participation in the Jefferies London Healthcare Conference, with an on-demand presentation available starting November 18, 2021, at 8:00 a.m. GMT (3:00 a.m. ET). A webcast will be accessible via the company's investor website, and an archived version will be available for 30 days. Verastem is dedicated to developing new cancer therapies, focusing on small molecule drugs that inhibit key signaling pathways critical for tumor growth and cell survival.
Verastem Oncology (Nasdaq: VSTM) has announced a clinical collaboration with Amgen to evaluate VS-6766 with LUMAKRAS™ in non-small cell lung cancer (NSCLC) and reported Q3 2021 results. The company has achieved a median progression-free survival (PFS) of 23.0 months in low-grade serous ovarian cancer (LGSOC), supported by FDA Breakthrough Therapy designation. However, Q3 revenues fell to $0 million from $78.6 million YoY, resulting in a net loss of $(22.8) million. Verastem expects a cash runway until at least 2024, with annual operating expenses projected at $55-60 million.
Verastem Oncology (Nasdaq: VSTM) announced the appointment of Michelle Robertson to its Board of Directors, effective November 15, 2021. Robertson, currently the CFO at Editas Medicine, will chair the audit committee, filling the vacancy left by Gina Consylman. The board's lead director, Michael Kauffman, praised Robertson's finance expertise as an asset amid ongoing development of RAS-targeted treatments. Robertson expressed enthusiasm about Verastem's commitment to improving outcomes for patients with RAS pathway cancers.
Verastem Oncology (Nasdaq: VSTM) announced the appointment of Louis J. Denis, MD, as Chief Medical Officer, granting him options to purchase 450,000 shares of common stock and 150,000 restricted stock units (RSUs). The stock options are part of an inducement material to his acceptance of the role, according to Nasdaq Listing Rule 5635(c)(4). A stock option of 300,000 shares will vest over time, while 150,000 shares will vest upon meeting specific clinical milestones. Both options have an exercise price of $2.81, based on the closing price on September 20, 2021.
Verastem Oncology (Nasdaq: VSTM) has appointed Dr. Louis J. Denis as Chief Medical Officer, bringing over 25 years of oncology experience to the company. Dr. Denis will lead efforts in advancing clinical trials, particularly for the VS-6766 and defactinib combination, which has shown promise in treating cancer. The company recently received FDA breakthrough therapy designation for low-grade serous ovarian cancer. Verastem is expanding its FRAME study into additional cancer types and anticipates growth through its ongoing registration-directed trials.
Verastem Oncology (Nasdaq: VSTM) announced a clinical collaboration with Amgen to evaluate its investigational drug VS-6766 alongside Amgen's LUMAKRAS in treating KRAS G12C-mutant non-small cell lung cancer (NSCLC). The Phase 1/2 trial will focus on safety and efficacy in treatment-naïve patients and those who have progressed on a KRAS G12C inhibitor. This collaboration aims to explore the potential of a vertical blockade of the RAS pathway to improve outcomes for patients. The trial is expected to begin by the end of 2021.
Verastem Oncology (NASDAQ: VSTM) has reported positive findings from the Phase 1/2 FRAME study of VS-6766 combined with defactinib for low-grade serous ovarian cancer (LGSOC). The median progression-free survival (mPFS) was 23.0 months, with an overall response rate of 46% across all patients and 64% in those with KRAS mutant LGSOC. The combination demonstrated manageable side effects and continues to progress toward a registration-directed Phase 2 study. Upcoming results from the registration study, RAMP 201, are anticipated in early 2022.