Welcome to our dedicated page for Vyne Therapeutics news (Ticker: VYNE), a resource for investors and traders seeking the latest updates and insights on Vyne Therapeutics stock.
News and disclosures about VYNE Therapeutics Inc. (VYNE) focus on its progress as a clinical-stage biopharmaceutical company developing BET inhibitor therapies for chronic inflammatory and immune-mediated conditions. Company press releases and SEC-referenced announcements cover clinical trial milestones, program updates, financial results and strategic transactions.
Investors following VYNE news can track detailed updates on its two principal BET inhibitor programs. For VYN202, an oral BD2-selective BET inhibitor, the company has issued multiple releases describing Phase 1b clinical data in moderate-to-severe plaque psoriasis, interactions with the U.S. Food and Drug Administration, and the impact of a clinical hold related to non-clinical toxicology findings in dogs. These communications outline protocol changes, preliminary safety and exploratory efficacy observations, and plans for additional toxicology work.
For repibresib gel, a locally administered pan-BD BET inhibitor, VYNE’s news flow includes topline results from a Phase 2b trial in nonsegmental vitiligo, analysis of primary and secondary endpoints, and the decision to discontinue the extension phase and terminate the trial. Releases also discuss the company’s intention to seek a development and commercialization partner for this program.
Regular financial news from VYNE includes quarterly and annual results, cash runway commentary, and descriptions of research and development and general and administrative spending. The company has also reported on a board-initiated strategic review to evaluate options such as partnerships, licensing, mergers or asset sales, and on cost reductions intended to extend its cash runway.
A major recent news theme is VYNE’s definitive merger agreement with Yarrow Bioscience, Inc. Announcements describe the all-stock transaction, expected ownership split between pre-merger stockholders, planned rebranding of the combined company as Yarrow Bioscience, Inc., and a future Nasdaq ticker symbol “YARW,” subject to closing conditions. Readers who monitor this news page can review the evolving narrative of VYNE’s pipeline, regulatory interactions, financial position and corporate transformation through official releases and referenced filings.
VYNE Therapeutics Inc. (Nasdaq: VYNE) announced that CEO David Domzalski will participate in a virtual fireside chat at the 42nd Annual Cowen Healthcare Conference on March 8, 2022, at 12:50 p.m. ET. The conference will provide an opportunity for investors to engage in 1-on-1 meetings with management. A webcast of the presentation is accessible via the provided link, and a replay will be available on the VYNE website for 90 days post-event. VYNE focuses on developing innovative therapies for immuno-inflammatory conditions, including its pipeline product FMX114 for atopic dermatitis.
VYNE Therapeutics has completed the Phase 1b portion of its clinical trial for FMX114, a topical treatment for mild-to-moderate atopic dermatitis. The formulation combines tofacitinib and fingolimod, showing significantly lower systemic drug exposure compared to oral forms. The mean plasma Cmax of tofacitinib was reported as 50-fold and 1500-fold lower at Days 1 and 14, respectively. The study, initially set for 6 subjects, was amended to 4 due to early data. Encouraging results support progression to Phase 2a, with topline results expected in Q1 2022.
VYNE Therapeutics has sold its Molecule Stabilizing Technology (MST) franchise, including the topical minocycline products AMZEEQ and ZILXI, to Journey Medical Corporation for $25 million upfront payments and potential milestone payments of up to $450 million. This strategic move aligns with VYNE's focus on developing its immuno-inflammatory pipeline, which includes FMX114 and InhiBET™ platform candidates. The cash proceeds will help support operations throughout 2022, with expected critical data releases from ongoing studies.
VYNE Therapeutics announced its participation in one-on-one investor meetings at the LifeSci Partners 11th Annual Corporate Access Event, scheduled virtually from January 5-7, 2022. The Company aims to enhance patient care through innovative therapies targeting immuno-inflammatory conditions. Key products include FMX114 for mild-to-moderate atopic dermatitis and a range of BET domain inhibitors for various conditions. Investors are encouraged to visit VYNE's website for further updates and disclosures.
VYNE Therapeutics Inc. (Nasdaq: VYNE) will participate in the Piper Sandler 33rd Annual Virtual Healthcare Conference, with CEO David Domzalski presenting a pre-recorded fireside chat available on the Company’s website starting November 22, 2021. The chat will commence at 10:00 a.m. Eastern Time. Additionally, VYNE management will hold 1-on-1 meetings with investors during the conference, scheduled from November 29 to December 2.
VYNE aims to develop innovative therapies for immuno-inflammatory conditions and rare skin diseases.
VYNE Therapeutics reported Q3 2021 revenues of $4.1 million, a rise from $3.3 million in Q3 2020, driven mainly by product sales. The company posted a net loss of $21.3 million, reducing from $24.7 million year-over-year. VYN201, the lead BET inhibitor candidate, showed significant promise in preclinical studies, reducing key pro-inflammatory cytokines and improving skin repair. VYNE expects to enter clinical trials for VYN201 in 2022 and anticipates Phase 2a results for FMX114 in early Q1 2022. The divestment process for its topical minocycline franchise is advancing successfully.
VYNE Therapeutics announced promising preclinical data for its BET inhibitor, VYN201, in treating autoimmune skin diseases. The study on hairless mice showed VYN201 significantly improved skin healing, reducing lesion severity scores and healing time compared to negative controls. Lesions treated with VYN201 healed in a mean time of 15.5 days versus 21 days for controls. Additionally, VYN201 treatment led to less fibrotic tissue, resulting in enhanced scar appearance. These results support the continued development of VYN201, aiming to address significant unmet medical needs in skin diseases.
VYNE Therapeutics Inc. (Nasdaq: VYNE) will announce its third-quarter financial results for the period ending September 30, 2021, on November 10, 2021, before market opening. A conference call and webcast will take place at 8:30 AM ET to discuss the results and provide updates on corporate developments. VYNE aims to improve patient lives through innovative therapies for immuno-inflammatory conditions and has a pipeline including FMX114 for atopic dermatitis.
VYNE Therapeutics Inc. announced promising preclinical data for its BET inhibitor, VYN201, demonstrating significant reductions in pro-inflammatory cytokines linked to Th17-mediated autoimmune diseases. In a murine model, a 0.1% dose of VYN201 achieved a 94% reduction in inflammation severity compared to vehicle controls, showing efficacy similar to a super-potent glucocorticosteroid. Furthermore, VYN201 exhibited better tolerance than clobetasol propionate, with treated mice showing normal weight gain. The compound also outperformed the JAK1/2 inhibitor ruxolitinib in ex vivo human skin tissue studies.
VYNE Therapeutics Inc. (Nasdaq: VYNE) has formed a Scientific Advisory Board (SAB) to support its strategy in developing novel treatments for immunological and inflammatory diseases. The SAB comprises leading experts who will provide guidance on the company’s pipeline, including its BET inhibitor drug candidates and FMX114 for atopic dermatitis. CEO David Domzalski emphasized the SAB’s role in optimizing the development of the company’s innovative therapies, aimed at addressing significant unmet medical needs in the treatment of these conditions.
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