Vyne Therapeutics Inc Stock Price, News & Analysis

VYNE Therapeutics announced promising preclinical data for its BET inhibitor, VYN201, in treating autoimmune skin diseases. The study on hairless mice showed VYN201 significantly improved skin healing, reducing lesion severity scores and healing time compared to negative controls. Lesions treated with VYN201 healed in a mean time of 15.5 days versus 21 days for controls. Additionally, VYN201 treatment led to less fibrotic tissue, resulting in enhanced scar appearance. These results support the continued development of VYN201, aiming to address significant unmet medical needs in skin diseases.

VYNE Therapeutics Inc. (Nasdaq: VYNE) will announce its third-quarter financial results for the period ending September 30, 2021, on November 10, 2021, before market opening. A conference call and webcast will take place at 8:30 AM ET to discuss the results and provide updates on corporate developments. VYNE aims to improve patient lives through innovative therapies for immuno-inflammatory conditions and has a pipeline including FMX114 for atopic dermatitis.

VYNE Therapeutics Inc. announced promising preclinical data for its BET inhibitor, VYN201, demonstrating significant reductions in pro-inflammatory cytokines linked to Th17-mediated autoimmune diseases. In a murine model, a 0.1% dose of VYN201 achieved a 94% reduction in inflammation severity compared to vehicle controls, showing efficacy similar to a super-potent glucocorticosteroid. Furthermore, VYN201 exhibited better tolerance than clobetasol propionate, with treated mice showing normal weight gain. The compound also outperformed the JAK1/2 inhibitor ruxolitinib in ex vivo human skin tissue studies.

VYNE Therapeutics Inc. (Nasdaq: VYNE) has formed a Scientific Advisory Board (SAB) to support its strategy in developing novel treatments for immunological and inflammatory diseases. The SAB comprises leading experts who will provide guidance on the company’s pipeline, including its BET inhibitor drug candidates and FMX114 for atopic dermatitis. CEO David Domzalski emphasized the SAB’s role in optimizing the development of the company’s innovative therapies, aimed at addressing significant unmet medical needs in the treatment of these conditions.

VYNE Therapeutics (Nasdaq: VYNE) has enrolled the first patient in a Phase 1b/2a clinical trial for FMX114, aimed at treating mild-to-moderate atopic dermatitis (AD). The investigational gel combines tofacitinib and fingolimod, targeting inflammation through dual mechanisms. The trial will assess safety and efficacy with a total of 31 subjects over various phases. Topline results are anticipated in early Q1 2022, marking a significant step in VYNE's strategy to develop innovative therapies for immuno-inflammatory diseases.

VYNE Therapeutics has announced the enrollment of the first patient in a Phase 3 study in China for AMZEEQ® (minocycline) topical foam, 4%, targeting moderate to severe acne. Conducted by Cutia Therapeutics, this study aims to secure regulatory approval for the product in China, expanding VYNE’s market reach. The study will enroll 372 patients across 29 sites, with the primary endpoint measuring changes in inflammatory lesion counts at Week 12. VYNE's licensing agreement with Cutia positions the company to earn royalties on net sales of AMZEEQ.

VYNE Therapeutics announced that David Domzalski, CEO, will present at the Cantor Fitzgerald Virtual Global Healthcare Conference from September 27-30, 2021. His presentation, a fireside chat, is scheduled for September 28 at 4 PM ET and will be available for archiving for 90 days. VYNE aims to enhance patient lives through innovative treatments for immuno-inflammatory conditions, with ongoing projects including FCD105 for acne and FMX114 for atopic dermatitis. VYNE has received FDA approvals for AMZEEQ and ZILXI, both minocycline topical products.

VYNE Therapeutics Inc. (Nasdaq: VYNE) announced that CEO David Domzalski will present at the H.C. Wainwright 23rd Annual Global Investment Conference, held virtually from September 13-15, 2021. The presentation will be a fireside chat available on demand starting September 13 at 7:00 AM (ET) and can be accessed for 90 days. Additionally, management will be available for one-on-one investor meetings. VYNE focuses on innovative therapies for immuno-inflammatory conditions and has FDA-approved products for acne and rosacea.

VYNE Therapeutics announced a license agreement for its BETi platform with In4Derm Limited and initiated a process to sell or license its topical minocycline franchise, aiming to reduce operating expenses significantly. The company plans to focus on immuno-inflammatory diseases and expects Phase 2a results for FMX114 by year-end. Financially, VYNE reported revenues of $4.3 million for Q2 2021, down from $11.7 million the previous year. Net loss for the quarter was $19.9 million, with a considerable reduction in operating costs anticipated.