Zai Lab Limited reports developments for a commercial-stage biopharmaceutical company with American depositary shares traded under ZLAB and ordinary shares listed in Hong Kong. The company discovers, develops, licenses and commercializes therapies for oncology, immunology, neuroscience and infectious disease, with operations based in China and the United States.
Recurring company updates include financial results, regulatory designations, clinical and preclinical data, collaborations and product updates across programs such as zocilurtatug pelitecan, ZL-1503, ZL-6201 and ZL-1222. Updates also address regional commercial products and pipeline assets including ZEJULA, VYVGART, KarXT and TIVDAK.
Zai Lab announced the dosing of the first patient in Greater China for the global MAHOGANY study, evaluating margetuximab in combination with a checkpoint inhibitor for HER2-positive gastric cancer and gastroesophageal junction cancer. This Phase 2/3 trial aims to assess margetuximab’s efficacy with or without chemotherapy. Gastric cancer is prevalent, with significant unmet medical needs. Zai Lab collaborates with MacroGenics for this study, which is crucial for addressing advanced stage cancers in China, where the prognosis is often poor.
Zai Lab Limited (NASDAQ: ZLAB) has initiated dosing of the first patient in China for the global Phase 3 POD1UM-304 study, evaluating retifanlimab alongside platinum-based chemotherapy for first-line metastatic non-small-cell lung cancer (NSCLC). The trial aims to enroll approximately 530 patients and focuses on overall survival and progression-free survival as primary endpoints. The collaboration with Incyte aims to address the significant unmet medical need for NSCLC treatment in China, where lung cancer is the leading cause of cancer deaths.
On September 28, 2020, Zai Lab announced its secondary listing on the Hong Kong Stock Exchange (stock code: 9688), successfully closing an offering of 10,564,050 new ordinary shares at HK$562.00 per share, equating to approximately US$72.52 per American depositary share. The gross proceeds from this offering are around HK$5.94 billion before costs. The international underwriters have an over-allotment option for an additional 1,584,600 shares. Zai Lab aims to enhance its presence in the rapidly growing Chinese pharmaceutical market.
Zai Lab Limited (NASDAQ: ZLAB) has successfully completed its secondary listing on the Hong Kong Stock Exchange under stock code '9688'. The listing involved the offering of 10,564,050 new ordinary shares at HK$562.00 per share, translating to approximately US$72.52 per American depositary share. The offering raised approximately HK$5.94 billion in gross proceeds. J.P. Morgan, Goldman Sachs, and Citigroup acted as joint sponsors and bookrunners for the listing. This strategic move aims to enhance Zai Lab’s presence in the fast-growing Asian market.
Zai Lab (SEHK:9688, NASDAQ:ZLAB), a biopharmaceutical company, has officially listed on the Main Board of The Stock Exchange of Hong Kong Limited as of September 27, 2020. The stock opened at HK$613.5, reflecting a 9.16% increase and a market capitalization of HK$52.724 billion. Founded in 2014 with Qiming Venture Partners as its earliest investor, Zai Lab focuses on innovative treatments for cancer, infectious, and autoimmune diseases. The company has a robust pipeline of 16 products, including two already commercialized in Greater China.
Zai Lab Limited (NASDAQ: ZLAB) announced the pricing of its Hong Kong secondary listing of 10,564,050 new ordinary shares at HK$562.00, approximately US$72.52 per ADS. The gross proceeds from this listing are estimated at HK$5.94 billion, with trading beginning on September 28, 2020, subject to regulatory approval. The company plans to utilize the funds for R&D and commercialization of core products, ongoing clinical trials, and expanding its internal pipeline. Notably, Zai Lab's ADSs will continue to be traded on NASDAQ.
Zai Lab Limited (NASDAQ: ZLAB) announced positive results from the NORA study, a Phase 3 trial showcasing niraparib as an effective maintenance therapy for patients with recurrent ovarian cancer. The treatment resulted in a 68% reduction in disease progression or death compared to placebo, with median progression-free survival of 18.3 months versus 5.4 months. An individualized dosing regimen reduced the incidence of hematological adverse events. The study's findings are critical for improving treatment standards in China.
Zai Lab Limited (NASDAQ: ZLAB) announced positive results from the Phase 3 NORA study presented at ESMO 2020, demonstrating that niraparib maintenance treatment led to a 68% reduction in the risk of disease progression or death compared to placebo. The median progression-free survival (PFS) for niraparib was significantly longer at 18.3 months, versus 5.4 months for placebo. An individualized dosing regimen reduced adverse events significantly. The study evaluated 265 patients, marking a key step in addressing treatment options for recurrent ovarian cancer in China.
Zai Lab has announced a Hong Kong public offering of 10,564,050 new ordinary shares, with 771,700 shares available in the public offering and 9,792,350 shares for international investors. The maximum offer price is set at HK$648.00 per share. The shares will be listed on the Hong Kong Stock Exchange under stock code 9688 and will be fully fungible with American depositary shares listed on Nasdaq. Proceeds will support R&D, clinical trials, and general corporate purposes. The application process will be entirely electronic, in line with the company's commitment to sustainability.
Zai Lab Limited (NASDAQ: ZLAB) announced that the China National Medical Products Administration (NMPA) has approved ZEJULA® (niraparib) for maintenance treatment in adults with advanced ovarian cancer following platinum-based chemotherapy. This approval marks ZEJULA as the first PARP inhibitor approved globally for all-comer patients in this context. The company emphasized ZEJULA’s potential to change treatment standards in China, highlighting its efficacy and safety. Zai Lab is actively pursuing several studies related to ZEJULA, which may further enhance its market position in oncology therapeutics.