Zentalis Pharmaceuticals, Inc. Stock Price, News & Analysis

Zentalis Pharmaceuticals (Nasdaq: ZNTL) announced participation in a fireside chat at the Jefferies Virtual Healthcare Conference on June 4, 2021, at 2:30 p.m. ET. Anthony Sun, MD, Chairman and CEO, along with Melissa Epperly, CFO, will represent the company. Interested parties can access the live webcast through the Investors section of Zentalis' website, with an archived version available post-event. Zentalis focuses on developing small molecule therapeutics targeting cancer biology, including candidates like ZN-c5 and ZN-c3.

Zentalis Pharmaceuticals (Nasdaq: ZNTL) reported encouraging initial results from the Phase 1 trial of its WEE1 inhibitor, ZN-c3, demonstrating single-agent activity and multiple Exceptional Responses in heavily pre-treated cancer patients. The company has entered a clinical collaboration with GSK to explore ZN-c3 in combination with niraparib. For Q1 2021, Zentalis had cash and securities of $298.4 million, but reported a net loss of $50.4 million, up from $16.2 million in Q1 2020 due to increased R&D costs.

Zentalis Pharmaceuticals announced a clinical collaboration with GlaxoSmithKline to evaluate ZN-c3, Zentalis' oral WEE1 inhibitor, in combination with ZEJULA (niraparib) for advanced ovarian cancer. This partnership aims to explore the enhanced potential of ZN-c3 as part of combination therapy, potentially improving patient outcomes. ZN-c3 is currently involved in various trials, with significant preclinical data supporting its efficacy. Over 300,000 women are diagnosed with ovarian cancer annually, highlighting the need for innovative treatments. Zentalis retains full ownership of ZN-c3.

Zentalis Pharmaceuticals announced promising initial data from the Phase 1 trial of ZN-c3, a WEE1 inhibitor, showing Exceptional Responses in patients with advanced solid tumors, including ovarian and colorectal cancer. The recommended Phase 2 dose has been set at 300 mg QD. Out of 55 patients, the treatment was well-tolerated, with manageable side effects primarily Grade 1/2. A webcast event is scheduled for April 12 to discuss these findings further.

Zentalis Pharmaceuticals (Nasdaq: ZNTL) reported its fourth quarter and full-year financial results for 2020, highlighting pivotal advancements in its oncology pipeline and strategic collaborations. As of December 31, 2020, the company had cash and marketable securities of approximately $338.5 million, enabling operations into 2023. Significant increases in research and development expenses reached $29.5 million in Q4 2020. The net loss for Q4 2020 was $40.4 million, compared to $14.5 million in the previous year.

Key developments included the initiation of multiple early-stage clinical trials and a collaboration with Tempus to enhance research capabilities.

Zentalis Pharmaceuticals (Nasdaq: ZNTL) announced three accepted abstracts for the AACR Annual Meeting 2021, including a late-breaking presentation on its WEE1 inhibitor, ZN-c3. The meeting will occur virtually from April 10-15 and May 17-21, 2021. Highlights include:

• A late-breaker session on the clinical activity of ZN-c3 in advanced solid tumors.
• Poster presentations on ZN-c3's selectivity and ZN-e4's anti-tumor effects in EGFR mutant lung cancer.

Data supports Zentalis' ability to differentiate its oncology therapeutic candidates.

Zentalis Pharmaceuticals (Nasdaq: ZNTL) has announced a strategic collaboration with Tempus to enhance its research capabilities. This partnership will utilize Tempus' patient-derived organoid biological modeling platform, mainly to evaluate Zentalis' WEE1 inhibitor, ZN-c3, for its effectiveness in various cancer treatments. ZN-c3 aims to induce DNA damage in cancer cells to inhibit tumor growth. The collaboration will help identify patient populations most likely to benefit from ZN-c3, positioning Zentalis favorably for clinical advancements.

Zentalis Pharmaceuticals, Inc. (Nasdaq: ZNTL) announced initial clinical data from its Phase 1 monotherapy trial of ZN-c3, a WEE1 inhibitor targeting advanced solid tumors. The data will be presented at the virtual American Association for Cancer Research (AACR) Annual Meeting 2021, scheduled for April 10-15 and May 17-21. ZN-c3 aims to induce DNA damage in cancer cells, promoting cell death and tumor regression. Currently, Zentalis is also conducting a Phase 1b trial combining ZN-c3 with chemotherapy and plans to initiate a Phase 2 trial for uterine serous carcinoma by year-end.

Zentalis Pharmaceuticals (Nasdaq: ZNTL) appointed Enoch Kariuki, PharmD, to its Board of Directors. Dr. Kariuki brings over a decade of experience in life sciences investment banking and business development. As a previous CFO of VelosBio, which was acquired by Merck, he has significant expertise in finance and strategic advising. His leadership is expected to enhance Zentalis' corporate financial strategy as the company advances its pipeline of oncology therapeutics, including ZN-c5 and ZN-c3.