Zentalis Pharmaceuticals Announces Multiple Data Presentations at Society of Gynecologic Oncology 2025 Annual Meeting on Women’s Cancer

Rhea-AI Summary

Zentalis Pharmaceuticals (NASDAQ: ZNTL) has announced multiple presentations at the upcoming Society of Gynecologic Oncology (SGO) 2025 Annual Meeting, scheduled for March 14-17 in Seattle. The presentations include updated clinical data from the Phase 2 DENALI trial of azenosertib in patients with platinum-resistant ovarian cancer (PROC).

Key highlights include an oral presentation by Dr. Fiona Simpkins focusing on Cyclin E1 as a predictive biomarker of azenosertib benefit in PROC patients, scheduled for March 15. Additionally, a poster presentation by Dr. Joanna Guo will showcase preclinical data demonstrating synergistic antitumor effects of azenosertib when combined with microtubule inhibitor-based antibody drug conjugates (ADCs).

Positive

• WEE1 inhibitor azenosertib shows potential as first-in-class and best-in-class treatment
• Identification of Cyclin E1 as predictive biomarker could improve patient selection
• Demonstrated synergistic effects with ADCs in preclinical studies

Negative

• None.

Updated clinical data from ongoing DENALI clinical trial of azenosertib in patients with PROC

Preclinical data of azenosertib demonstrating antitumor effects with microtubule inhibitor based ADCs

SAN DIEGO, March 03, 2025 (GLOBE NEWSWIRE) -- Zentalis^® Pharmaceuticals, Inc. (Nasdaq: ZNTL), a clinical-stage biopharmaceutical company developing a potentially first-in-class and best-in-class WEE1 inhibitor for patients with ovarian cancer and other tumor types, today announced multiple presentations, including an oral presentation with updated clinical data from the ongoing Phase 2 DENALI clinical trial of azenosertib in patients with platinum-resistant ovarian cancer (PROC), at the Society of Gynecologic Oncology (SGO) 2025 Annual Meeting on Women’s Cancer, to be held on March 14-17 in Seattle, Washington.

Oral Presentation

• Abstract Title: Cyclin E1 is a Predictive Biomarker of Azenosertib Benefit in Platinum-Resistant Ovarian Cancer (PROC): Outcomes from Part 1b of the DENALI Study (GOG-3066)
• Presenter: Fiona Simpkins, M.D.
• Session: Scientific Plenary II: Hitting the Target - Maximizing IMPACT
• Date/Time: Saturday, March 15, 8:25am PST

Poster Presentation

• Abstract Title: The WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Effects With Microtubule Inhibitor–Based Antibody Drug Conjugates (ADCs) in Preclinical Models
• Presenter: Joanna Guo, Ph.D.
• Session: In-Person Poster Session
• Date and Time: Sunday, March 16, 8:15-8:45am and 2:10-3:00pm PST

About Zentalis Pharmaceuticals  
Zentalis^® Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company developing azenosertib (ZN-c3), a potentially first-in-class and best-in-class WEE1 inhibitor for patients with Cyclin E1+ platinum-resistant ovarian cancer (PROC). Azenosertib is being evaluated as a monotherapy and in combination across multiple tumor types in clinical trials and has broad franchise potential. In clinical trials, azenosertib has been well tolerated and has demonstrated anti-tumor activity as a single agent across multiple tumor types. The Company is also leveraging its extensive experience and capabilities to translate its science to advance research on additional areas of opportunity for azenosertib outside PROC. Zentalis has operations in San Diego. 

For more information, please visit www.zentalis.com. Follow Zentalis on X/Twitter at @ZentalisP and on LinkedIn at www.linkedin.com/company/zentalis-pharmaceuticals. 

Contact: 
Haibo Wang - Chief Business Officer
Ron Moldaver - Investor Relations
ir@zentalis.com  

FAQ

What will Zentalis (ZNTL) present at the SGO 2025 Annual Meeting?

Zentalis will present updated clinical data from the Phase 2 DENALI trial of azenosertib in PROC patients and preclinical data showing antitumor effects with ADCs.

When and where is Zentalis (ZNTL) presenting at the SGO 2025 Meeting?

The presentations will take place March 14-17, 2025, in Seattle, with the main oral presentation scheduled for March 15 at 8:25am PST.

What is the focus of the DENALI trial presentation for ZNTL's azenosertib?

The presentation focuses on Cyclin E1 as a predictive biomarker of azenosertib benefit in platinum-resistant ovarian cancer patients.

What are the preclinical findings for Zentalis's (ZNTL) azenosertib with ADCs?

The preclinical data shows synergistic antitumor effects when combining azenosertib with microtubule inhibitor-based antibody drug conjugates.