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CelLBxHealth plc (traded in the United States under the symbol ANPCF and on AIM under CLBX, and previously known as ANGLE plc) is a healthcare company in the Diagnostics & Research industry focused on circulating tumour cell (CTC) analysis. According to company announcements, it describes itself as a global precision CTC intelligence and liquid biopsy company, developing and commercialising CTC-based solutions for use in research, drug development and clinical oncology using a simple blood sample.

The company’s core technology is its patent-protected Parsortix® platform, a CTC harvesting system that enriches CTCs from blood based on cell size and deformability. Company disclosures state that the Parsortix system enables comprehensive downstream analysis of harvested cells, including whole-cell imaging, proteomic profiling and full genomic and transcriptomic molecular workflows. This approach is intended to support applications in cancer research, pharmaceutical clinical trials and, where permitted, clinical oncology.

Business focus and commercial activities

CelLBxHealth’s commercial activities, as described in its regulatory and news releases, centre on several related areas built around the Parsortix platform and associated technologies. These include:

• Product sales: The company reports that its product portfolio comprises the Parsortix platform with associated consumables and assays. In various announcements it notes efforts to accelerate platform adoption and consumable use through partnerships with contract research organisations (CROs), clinical laboratories and other industry partners.
• Clinical and biopharma services: Company statements describe a services business delivered from a GCLP-compliant UK laboratory. These services include custom assay development, clinical-trial testing for pharmaceutical and biotechnology companies, and broader biopharma clinical services using CTC enrichment.
• Laboratory-developed tests (LDTs): CelLBxHealth highlights work on LDTs through strategic partnerships and an internal development programme, with a focus on CTC-based precision oncology applications.
• Research Use Only (RUO) validation: The company has stated that it undertakes RUO validation of existing commercial proteomic and genomic assays on CTC samples generated by the Parsortix system.

Across these activities, CelLBxHealth positions its CTC technology as a way to provide high-value CTC-based precision diagnostic testing for the pharmaceutical services sector and the clinical diagnostics market, subject to the intended use and regulatory status of each product or service.

Technology and applications

In its announcements, the company describes Parsortix as an FDA-cleared and patent-protected CTC harvesting technology (in the form of the Parsortix PC1 System) intended to enrich CTCs from peripheral blood. The system uses a microfluidic cassette to capture cells of a certain size and deformability, after which the retained cells can be harvested for use in downstream assays. The company emphasises that the standalone device does not itself identify, enumerate or characterise CTCs and cannot be used to make diagnostic or prognostic claims; the end user is responsible for validating any downstream assay.

CelLBxHealth also refers to its proprietary CellKeep™ slide, used for high-quality imaging of CTCs. Company communications note that its GCLP-certified UK laboratory delivers bespoke clinical-trial support and assay development, and that over one hundred peer-reviewed publications have reported on the performance of the Parsortix system in a range of cancer types and research settings.

Public updates from the company highlight applications in areas such as metastatic breast cancer and glioblastoma, where CTC isolation and analysis are presented as potential tools for minimally invasive, repeatable monitoring of tumour biology, disease progression and response to therapy. In addition, CelLBxHealth has reported collaborations with large pharmaceutical and medtech companies to integrate Parsortix-derived CTC samples with existing molecular and proteomic assays, including next-generation sequencing workflows.

Corporate evolution and naming

Several announcements describe the company’s transition from ANGLE plc to CelLBxHealth plc. ANGLE plc, already active in CTC-based liquid biopsy, outlined a revised strategy focused on what it termed “CTC intelligence” and proposed a change of name to CelLBxHealth plc, with a corresponding change of AIM ticker to CLBX. Subsequent releases refer to CelLBxHealth plc as a global precision CTC intelligence company and describe continuity in the use of the Parsortix platform, associated consumables and assays, and GCLP-compliant laboratory services.

According to these disclosures, the new name is intended to reflect a sharpened focus on CTC-based precision diagnostics and the broader concept of liquid biopsy (“LBx”), with an emphasis on supporting pharmaceutical companies and clinicians in improving outcomes for cancer patients. The company continues to be referenced as a UK issuer in regulatory notifications and is associated with operations in Guildford, Surrey.

Position within diagnostics and research

Within the Diagnostics & Research industry and healthcare sector, CelLBxHealth presents itself, through its public communications, as a specialist in CTC-based liquid biopsy technologies. Its work spans research use, clinical-trial support and, where appropriately validated and authorised, clinical oncology applications. Company materials emphasise the potential of CTCs to provide biological information that may not be captured by circulating tumour DNA, and to support precision oncology by enabling detailed analysis of living tumour cells obtained from blood.

Investors and researchers considering ANPCF can review the company’s statements to understand how it combines device development, laboratory services, assay development and collaborations with pharmaceutical and medtech partners around a single CTC enrichment platform. All claims about technology capabilities and intended uses are subject to the detailed indications, limitations and regulatory clearances described in the company’s own documentation.

FAQs about CelLBxHealth plc (ANPCF)

• What does CelLBxHealth plc do?
  

  According to its announcements, CelLBxHealth plc is a precision CTC intelligence and liquid biopsy company. It focuses on circulating tumour cell solutions for research, drug development and clinical oncology, built around its Parsortix CTC harvesting platform, associated consumables and assays, and GCLP-compliant laboratory services.

• What is the Parsortix® platform?
  

  The company describes Parsortix as a patent-protected CTC harvesting technology that enriches circulating tumour cells from blood based on size and deformability. The harvested cells can then be used for downstream analysis, including whole-cell imaging, proteomic profiling and genomic workflows. The Parsortix PC1 System has an FDA-cleared indication for enriching CTCs from peripheral blood in certain metastatic breast cancer patients, with downstream assays requiring separate validation by the end user.

• How does CelLBxHealth generate revenue?
  

  Company disclosures indicate that revenue-generating activities include product sales of the Parsortix platform, consumables and assays, as well as clinical and biopharma services delivered from its GCLP-compliant laboratory. These services encompass custom assay development, clinical-trial testing and broader biopharma clinical services using CTC enrichment. The company also refers to work on laboratory-developed tests and Research Use Only validation of external assays on Parsortix-derived samples.

• What markets does CelLBxHealth target?
  

  In its public statements, CelLBxHealth highlights two main markets: the pharmaceutical services sector and the clinical diagnostics market. It focuses on supporting large pharma, medtech companies, CROs and clinical laboratories with CTC-based testing capabilities, particularly in oncology research and drug development, and in precision oncology contexts where permitted.

• How is CelLBxHealth’s technology used in clinical research?
  

  Company updates describe the use of Parsortix-derived CTC samples in clinical trials run by pharmaceutical and biotechnology companies, including projects with large pharma. The GCLP-compliant laboratory provides CTC enrichment, custom assay development and clinical-trial testing services, and the company reports that multiple peer-reviewed publications have used its technology to study CTCs across different tumour types.

• What is meant by “CTC intelligence”?
  

  CelLBxHealth uses the term “CTC intelligence” in its communications to describe the generation of detailed biological information from circulating tumour cells harvested from blood. This includes imaging, proteomic and genomic analyses that can be applied in research, drug development and, where validated and authorised, clinical decision support in oncology.

• How does CelLBxHealth differentiate CTCs from circulating tumour DNA (ctDNA)?
  

  In its commentary on expert consensus publications, the company notes that CTCs can provide distinct information not captured by ctDNA, particularly regarding protein expression on cell surfaces and the biology of intact tumour cells. It presents CTCs as complementary to ctDNA, with potential advantages in certain applications such as targeted therapy selection and real-time monitoring of tumour characteristics.

• What is the role of the GCLP-compliant UK laboratory?
  

  CelLBxHealth states that its UK laboratory operates under Good Clinical Laboratory Practice (GCLP) standards and delivers biopharma clinical services and laboratory services. These include bespoke clinical-trial support, assay development, and CTC enrichment for clinical studies, using the Parsortix platform and related technologies.

• Has the company undergone a name change?
  

  Yes. ANGLE plc announced a revised strategy focused on CTC intelligence and proposed a change of name to CelLBxHealth plc, with a new AIM ticker CLBX. Later announcements and descriptions refer to CelLBxHealth plc as the operating company, while U.S. investors may still encounter the historical association with ANGLE plc when researching the ANPCF symbol.

• Where can investors find more detail on CelLBxHealth’s technology and intended use?
  

  The company’s own regulatory announcements and supporting materials, as referenced in its news releases, provide detailed descriptions of the Parsortix system’s intended use, limitations and regulatory status, including the indication for the Parsortix PC1 System and the responsibilities of end users in validating downstream assays.