Coherus Stock Price, News & Analysis

Coherus Oncology, Inc. (NASDAQ: CHRS) is a commercial-stage oncology company focused on developing and commercializing antibody-based cancer therapies. The company describes itself as a fully integrated organization with an approved next-generation PD-1 inhibitor, LOQTORZI (toripalimab-tpzi), and a proprietary immuno-oncology pipeline that includes multiple clinical-stage candidates targeting a range of solid tumors, including liver, lung, head and neck, colorectal, gastric, esophageal and other cancers.

According to multiple company disclosures, Coherus Oncology’s strategy centers on growing sales of LOQTORZI in nasopharyngeal carcinoma (NPC) and advancing new indications for LOQTORZI in combination with its pipeline candidates and partners’ agents. LOQTORZI is described as a next-generation PD-1 inhibitor and is approved in the United States for recurrent, locally advanced or metastatic NPC in adults, either in combination with chemotherapy or as a single agent after platinum-containing chemotherapy.

Core commercial product: LOQTORZI

LOQTORZI (toripalimab-tpzi) is Coherus Oncology’s approved PD-1 inhibitor. Company communications state that LOQTORZI is indicated in combination with cisplatin and gemcitabine for first-line treatment of adults with metastatic or recurrent, locally advanced NPC, and as a single agent for adults with recurrent unresectable or metastatic NPC with disease progression on or after platinum-containing chemotherapy. Coherus reports that LOQTORZI is marketed in the U.S. in two indications within NPC and that it remains the only FDA-approved and available treatment in the U.S. for recurrent, locally advanced or metastatic NPC in all patient subsets and across all lines of therapy.

Coherus highlights long-term clinical data from the JUPITER-02 Phase 3 trial evaluating LOQTORZI plus chemotherapy in recurrent or metastatic NPC. In a six-year follow-up analysis, the LOQTORZI plus chemotherapy arm showed a higher median overall survival compared to chemotherapy alone in this setting, reinforcing the company’s focus on NPC as a key commercial and clinical opportunity.

Pipeline and research focus

Beyond LOQTORZI, Coherus Oncology emphasizes a proprietary immuno-oncology pipeline built around antibody immunotherapies aimed at enhancing innate and adaptive immune responses against tumors. The company repeatedly identifies two mid-stage clinical candidates as central to this pipeline:

• CHS-114 / Tagmokitug: a highly selective cytolytic anti-CCR8 monoclonal antibody designed to target CCR8+ regulatory T cells (Tregs) in the tumor microenvironment.
• Casdozokitug: a novel IL-27 antagonistic antibody being evaluated in patients with advanced solid tumors, including hepatocellular carcinoma (HCC) and non-small cell lung cancer (NSCLC), depending on the specific trial.

Company press releases describe CHS-114 (also referred to as tagmokitug in certain contexts) as an afucosylated, cytolytic CCR8 monoclonal antibody intended to selectively deplete CCR8+ Tregs within tumors while sparing other T cell subsets in normal tissue. Early clinical and biomarker data from Phase 1b/2a studies in advanced solid tumors, including head and neck squamous cell carcinoma, colorectal cancer, gastric cancer and esophageal cancer, have been reported by the company as showing selective depletion of CCR8+ Tregs and increases in intratumoral CD8+ T cells, supporting proof of mechanism and tumor microenvironment remodeling.

Casdozokitug is described as a first-in-class, clinical-stage IL-27 antagonist with monotherapy activity in treatment-refractory NSCLC and clear cell renal cell carcinoma and combination activity in HCC, based on company communications. It is being evaluated in randomized Phase 2 and other Phase 1/2 studies, including in first-line hepatocellular carcinoma in combination with toripalimab and bevacizumab.

Combination strategy and indications

Across its disclosures, Coherus Oncology consistently emphasizes a combination-based development strategy. The company aims to expand the use of LOQTORZI by combining it with CHS-114, casdozokitug and partners’ agents in multiple solid tumor settings. Examples mentioned in company materials include:

• Head and neck squamous cell carcinoma (HNSCC), where CHS-114 is being evaluated as monotherapy and in combination with toripalimab in recurrent/metastatic disease.
• Gastric and esophageal cancers, where CHS-114 plus toripalimab is being studied in Phase 1b settings.
• Colorectal cancer, where the CHS-114 clinical program has been expanded to include later-line patients.
• Hepatocellular carcinoma, where casdozokitug with toripalimab and bevacizumab is being evaluated in first-line treatment.
• Other advanced solid tumors, including NSCLC and additional liver cancer settings, where casdozokitug has been studied in Phase 1/2 trials.

Coherus states that its immuno-oncology pipeline is focused on enabling robust antitumor responses and improving outcomes for patients with cancer by modulating both innate and adaptive immunity. The company’s approach, as described in its communications, is to drive "sales multiples and synergies" from proprietary combinations of LOQTORZI with internal and partnered assets.

Corporate and listing information

Coherus Oncology, Inc. is listed on The Nasdaq Global Market under the ticker symbol CHRS, as confirmed in multiple Form 8-K filings. These filings identify the company as Coherus Oncology, Inc. and specify that its common stock has a par value of $0.0001 per share. The company has disclosed receiving a Nasdaq deficiency notice in June 2025 related to its minimum bid price requirement and later reported regaining compliance with Nasdaq Listing Rule 5550(a)(2) in September 2025, with the Nasdaq staff confirming that the company was in full compliance with all continued listing standards of the Nasdaq Global Market at that time.

The company describes itself as a fully integrated commercial-stage entity, indicating that it is engaged in both the development and commercialization of oncology products. Coherus has also reported divestitures of non-oncology franchises in prior periods and a strategic focus on innovative cancer therapies, though those divestitures and related historical products are not the focus of its recent oncology-centered communications.

Regulatory and clinical disclosure practices

Coherus Oncology regularly provides updates on its financial performance, clinical development programs and business strategy through press releases and SEC filings, including Form 8-Ks that furnish quarterly financial results. The company also notes that it uses its investor relations website as a channel for disclosing material information in compliance with Regulation FD. Clinical and scientific data related to its pipeline, such as biomarker analyses and proof-of-mechanism findings for CHS-114 and tagmokitug, are shared in peer-reviewed publications and at scientific meetings, according to its news releases.

Investment and risk considerations

Company press releases frequently include forward-looking statements that highlight risks and uncertainties inherent in drug development, commercialization, financing and regulatory processes. These statements underscore that expectations about sales growth, clinical trial timelines, potential label expansions, partnerships and pipeline impact on patient outcomes are subject to change and depend on numerous factors described in Coherus Oncology’s SEC filings.

FAQs about Coherus Oncology, Inc. (CHRS)

• What does Coherus Oncology, Inc. do?
  Coherus Oncology, Inc. is a commercial-stage oncology company focused on antibody-based cancer therapies. It markets the PD-1 inhibitor LOQTORZI (toripalimab-tpzi) for nasopharyngeal carcinoma in the United States and is developing additional immuno-oncology candidates, including CHS-114 and casdozokitug, across multiple solid tumor indications.
• What is LOQTORZI and how is it used?
  LOQTORZI (toripalimab-tpzi) is a next-generation PD-1 inhibitor approved in the U.S. for adults with metastatic or recurrent, locally advanced nasopharyngeal carcinoma in combination with cisplatin and gemcitabine, and as a single agent for adults with recurrent unresectable or metastatic NPC after platinum-containing chemotherapy. Coherus describes LOQTORZI as the only FDA-approved and available treatment in the U.S. covering all NPC patient subsets and lines of therapy.
• What are CHS-114 and tagmokitug?
  Company materials describe CHS-114 as a highly selective cytolytic anti-CCR8 antibody designed to deplete CCR8+ regulatory T cells in tumors. Tagmokitug is identified as an investigational monoclonal antibody that selectively targets CCR8 and is part of Coherus Oncology’s next-generation immunotherapy pipeline. Tagmokitug is being evaluated in Phase 1b/2a clinical trials in patients with solid tumors in combination with toripalimab and chemotherapy.
• What is casdozokitug?
  Casdozokitug is described by Coherus Oncology as a novel IL-27 antagonistic antibody in clinical development. It is being evaluated in multiple Phase 1/2 and Phase 2 studies in patients with advanced solid tumors, including non-small cell lung cancer and hepatocellular carcinoma, and in a randomized Phase 2 trial in first-line hepatocellular carcinoma in combination with toripalimab and bevacizumab.
• Which cancers does Coherus Oncology focus on?
  According to its disclosures, Coherus focuses on solid tumors such as nasopharyngeal carcinoma, head and neck squamous cell carcinoma, colorectal cancer, gastric cancer, esophageal cancer, hepatocellular carcinoma, non-small cell lung cancer and other advanced solid tumors. Its development programs are structured around these indications for LOQTORZI, CHS-114/tagmokitug and casdozokitug.
• On which exchange does CHRS trade?
  Coherus Oncology, Inc. common stock trades on The Nasdaq Global Market under the ticker symbol CHRS, as stated in its Form 8-K filings.
• Has Coherus Oncology faced any Nasdaq listing issues?
  The company reported receiving a Nasdaq deficiency notice on June 30, 2025, because its common stock bid price had closed below $1.00 per share for 30 consecutive business days. On September 5, 2025, Coherus announced that Nasdaq notified the company it had regained compliance with the minimum bid price requirement and that the matter was closed, with the company in full compliance with Nasdaq Global Market continued listing standards.
• How does Coherus describe its overall strategy?
  Coherus Oncology states that its strategy is to grow LOQTORZI sales in nasopharyngeal carcinoma and to advance development of new indications for LOQTORZI in combination with its internal pipeline candidates and partners’ therapies. The company seeks to generate sales growth and synergies from proprietary combinations of its immuno-oncology agents.