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Invitae (OTC: NVTA) is described in its public communications as a medical genetics company that focuses on delivering genetic information using digital technology. The company states that it aims to provide accurate and actionable answers that can strengthen medical decision-making for individuals and their families. Invitae emphasizes the use of genetics experts, a rigorous approach to data and research, and the integration of genetic information into mainstream medicine to improve healthcare for large patient populations.

According to multiple company press releases, Invitae positions itself as a medical genetics company trusted by patients and healthcare providers to deliver timely genetic information. Its activities include clinical genetic testing for hereditary disease and the generation and interpretation of genetic variants. Invitae highlights that it has provided clinical testing for millions of patients, creating an extensive dataset that supports both clinical care and research collaborations.

Business focus and genetic testing

Invitae describes its core focus as genetic testing for hereditary disease, including hereditary cancer and other genetic conditions. Company materials explain that germline genetic testing is used to assess hereditary cancer predisposition and to inform surgical, medical, and surveillance strategies. Invitae reports that genetic testing has become a standard part of care in areas such as hereditary breast cancer, and that its work includes studying how uncertain genetic results relate to clinical decisions, such as breast surgery utilization.

The company also reports that it has developed and operates platforms for variant detection and classification. In its descriptions of Invitae Generation™, Invitae refers to a high-quality variant detection and classification platform that combines scientific experts, technology platforms, a systematic framework, and a large genetics database to classify unique genetic variants. This work is presented as a way to provide more definitive answers to patients undergoing clinical genetic testing.

Use of data, AI and machine learning

Invitae states that it maintains a large database of genetic and clinical information from patients who have undergone testing. In partnership and research announcements, the company notes that this dataset is enriched for rare diseases and can be used to deepen understanding of genetic-driven disease. Invitae reports that it analyzes longitudinal medical phenotypes in linked genetic and clinical datasets to understand disease burden in real-world settings and to support therapeutic discovery efforts with partners.

The company describes the use of machine learning and AI-based approaches in several contexts. For example, Invitae has announced a machine learning approach called Clinical Variant Modeling, which is described as a method designed to aid clinical interpretation of genetic testing results and increase the rate of definitive answers for patients. According to Invitae, this approach leverages clinical information received at the time of testing and uses large genomic datasets to improve variant classification and reduce variants of uncertain significance (VUS) in hereditary disease testing.

Invitae has also presented research on gene-specific machine learning models for hereditary breast cancer testing and Lynch syndrome genes. In these communications, the company reports that machine learning models can contribute to reclassifying uncertain variants into more definitive categories, which can reduce uncertainty for clinicians and patients and may help address disparities linked to underrepresented racial, ethnic, and ancestral populations in genomic databases.

Research, collaborations and rare disease focus

Invitae regularly highlights its participation in scientific meetings and collaborations. In connection with the American College of Medical Genetics and Genomics (ACMG) Annual Clinical Genetics Meeting, Invitae has described research on variant reclassification, variant interpretation, and the use of large patient cohorts for studying genetic variants across a wide range of conditions. The company reports that its work includes studies on variant stability over time, the contribution of machine learning to reclassification, and the use of functional models and RNA analysis in hereditary cancer testing.

Invitae also reports collaborations with biopharmaceutical companies. For example, the company announced a partnership with BridgeBio Pharma focused on genetics-based drug discovery for rare diseases. In that context, Invitae states that it will analyze genetic and phenotypic data, apply AI-based phenotypic clustering, and conduct association testing to identify potential genetic modifiers and therapeutic targets. These activities are presented as an extension of Invitae’s role in generating and interpreting genetic data for patients with genetic-driven disease.

Corporate developments and restructuring

Invitae has communicated significant corporate and financial developments. In a public announcement, the company stated that it filed for voluntary chapter 11 protection in the U.S. Bankruptcy Court for the District of New Jersey. Invitae described this step as part of efforts to manage costs, improve its business structure, and pursue a sale process with the support of senior noteholders. The company indicated that it intends to use cash on hand to operate its business during the proceedings and to continue serving customers and patients while the chapter 11 process is underway.

In another announcement, Invitae reported that Labcorp was selected as the winning bidder in a court-supervised sale process under Section 363 of the U.S. Bankruptcy Code. According to Invitae, Labcorp agreed to acquire substantially all of the company’s assets on a going concern basis for cash and other consideration, subject to court and regulatory approvals and customary closing conditions. Invitae has characterized this agreement as a significant step in its financial restructuring and as supporting continued delivery of its products and services.

Invitae has also reported transactions involving specific business lines. For example, a separate announcement from Natera stated that Natera acquired certain assets related to Invitae’s non-invasive prenatal screening and carrier screening business, with Invitae transitioning those customers to Natera. These developments indicate that Invitae has engaged in asset sales and portfolio realignment as part of its broader restructuring efforts.

Position within the healthcare and genetics sector

Across its public statements, Invitae consistently describes itself as a medical genetics company operating within the health care sector, with activities that intersect clinical laboratories, genetic testing, and genomic data analysis. The company emphasizes the role of genetic information in routine medical practice, the importance of accurate variant classification, and the potential for genetic data to inform both individual patient care and rare disease research. Its communications highlight work in hereditary cancer, rare diseases, and other genetic conditions where germline testing can inform clinical management.

Invitae’s descriptions of its mission and activities focus on integrating comprehensive genetic information into mainstream medicine, using digital technology and large-scale data resources. Through its testing services, research presentations, and collaborations, the company presents itself as contributing to the broader use of genetics in healthcare decision-making, while also navigating a court-supervised restructuring and asset sale process.