Agios CLO exercises 8,500 PSUs, sells 3,280 shares

Agios Pharmaceuticals Chief Legal Officer James William Burns exercised 8,500 performance share units into 8,500 shares of common stock.

Rhea-AI Filing Summary

Agios Pharmaceuticals Chief Legal Officer James William Burns exercised 8,500 performance share units into 8,500 shares of common stock. The PSUs vested when a specified regulatory milestone was determined to be met on April 2, 2026. On the same date, 3,280 shares were sold at $34.71 per share to cover tax withholding obligations under durable automatic sale instructions consistent with Rule 10b5-1(c). Following these transactions, Burns directly holds 49,306 shares of Agios common stock.

Insider Trade Summary 10b5-1

Exercise and sale activity reported; no spread calculated

Exercise and Sale 3 txns

Insider Burns James William

Role Chief Legal Officer

Sold 3,280 shs ($114K)

Approx. gross sale proceeds $114K

Approx. exercise cost $0.00

Type	Security	Shares	Price	Value
Exercise	Performance share units	8,500	$0.00	$0.00
Exercise	Common stock	8,500	$0.00	$0.00
Sale	Common stock	3,280	$34.71	$114K

Holdings After Transaction: Performance share units — 8,500 contracts (Direct); Common stock — 49,306 shares (Direct)

Footnotes (3)

1. F1. Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's performance share unit agreement dated March 1, 2024.
2. F2. Each performance share unit represents a contingent right to receive one share of the issuer's common stock.
3. F3. The PSUs were granted on March 1, 2024. The PSUs vest as to 50% of the underlying shares upon the achievement of a specified regulatory milestone and as to the remaining 50% of the underlying shares upon the achievement of a specified commercial milestone. The performance criteria for the specified regulatory milestone was determined to have been met on April 2, 2026, resulting in the vesting of the PSUs as to 50% of the underlying shares. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

Key Figures

PSUs exercised: 8,500 units Shares sold: 3,280 shares Sale price: $34.71 per share +4 more

7 metrics

PSUs exercised 8,500 units Performance share units converted to common stock on April 2, 2026

Shares sold 3,280 shares Common stock sold on April 2, 2026 to cover tax withholding

Sale price $34.71 per share Price for 3,280 common shares sold

Shares held after transactions 49,306 shares Direct common stock ownership following April 2, 2026 transactions

Net buy/sell shares -3,280 shares Net effect of open-market sale relative to exercises

PSU grant date March 1, 2024 Original grant date of performance share units

Regulatory milestone date April 2, 2026 Date regulatory milestone was determined met, triggering 50% PSU vesting

Key Terms

Performance share units, tax withholding obligation, Rule 10b5-1(c), regulatory milestone, +1 more

5 terms

Performance share units financial

"Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units."

Performance share units are a type of company stock award given to employees that depend on the company meeting specific goals or targets. If these goals are achieved, the employee receives shares or the value of shares; if not, they may receive little or no compensation. This aligns employees’ interests with the company's success and encourages performance that benefits investors.

tax withholding obligation financial

"Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units."

Rule 10b5-1(c) regulatory

"durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act."

Rule 10b5-1(c) is an SEC guideline that lets company insiders set up a written, pre-planned schedule to buy or sell their company stock when they are not in possession of material, nonpublic information. For investors, it matters because such plans can reduce the appearance of insider trading by separating decisions from inside knowledge—like putting your trades on autopilot—while also requiring scrutiny since pre-planned trades can still affect market confidence and share value.

regulatory milestone financial

"The PSUs vest as to 50% of the underlying shares upon the achievement of a specified regulatory milestone"

commercial milestone financial

"and as to the remaining 50% of the underlying shares upon the achievement of a specified commercial milestone."

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What insider transaction did AGIOS PHARMACEUTICALS (AGIO) report for James William Burns?

Agios Pharmaceuticals Chief Legal Officer James William Burns exercised 8,500 performance share units into common stock, then sold 3,280 shares on the same date to cover tax withholding. After these transactions, he directly holds 49,306 common shares.

At what price were James William Burns’ AGIO shares sold and why?

Burns sold 3,280 shares of Agios common stock at $34.71 per share. According to the disclosure, the shares were sold specifically to cover the tax withholding obligation related to the vesting of his performance share units, under automatic sale instructions.

How many AGIO shares does James William Burns hold after these transactions?

Following the exercise and related sale, James William Burns directly holds 49,306 shares of Agios Pharmaceuticals common stock. This figure reflects his position after converting 8,500 performance share units and selling 3,280 shares to satisfy tax withholding needs.

What triggered the vesting of James William Burns’ performance share units at Agios (AGIO)?

The performance share units vested when a specified regulatory milestone was determined to have been met on April 2, 2026. This determination caused 50% of the underlying PSU shares to vest, leading to the delivery and related tax sale of shares.

Were James William Burns’ AGIO share sales discretionary or pre-arranged?

The sale of 3,280 shares was executed under durable automatic sale instructions included in his March 1, 2024 performance share unit agreement. These instructions are described as consistent with the Rule 10b5-1(c) affirmative defense, indicating a pre-arranged process.

What are AGIO performance share units as used in James William Burns’ award?

Each performance share unit (PSU) represents a contingent right to receive one share of Agios common stock. For this award, 50% vests upon a regulatory milestone and the remaining 50% vests upon a specified commercial milestone, according to the disclosure.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Accepted by SEC EDGAR 04/06/2026 - 04:11 PM Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

X

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Burns James William

(Last) (First) (Middle)

88 SIDNEY STREET

(Street)

CAMBRIDGE MASSACHUSETTS 02139

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
AGIOS PHARMACEUTICALS, INC. [ AGIO ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief Legal Officer

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
04/02/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common stock	04/02/2026		M		8,500	A	$0	52,586	D
Common stock	04/02/2026		S(1)		3,280	D	$34.71	49,306	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Performance share units	(2)	04/02/2026		M			8,500	(3)	(3)	Common stock	8,500	$0	8,500	D

Explanation of Responses:

1. Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's performance share unit agreement dated March 1, 2024.

2. Each performance share unit represents a contingent right to receive one share of the issuer's common stock.

3. The PSUs were granted on March 1, 2024. The PSUs vest as to 50% of the underlying shares upon the achievement of a specified regulatory milestone and as to the remaining 50% of the underlying shares upon the achievement of a specified commercial milestone. The performance criteria for the specified regulatory milestone was determined to have been met on April 2, 2026, resulting in the vesting of the PSUs as to 50% of the underlying shares. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

Remarks:

	/s/ William Cook, as Attorney in Fact for James Burns	04/06/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)