| Item 1. | Security and Issuer |
| (a) | Title of Class of Securities:
Ordinary Shares, $0.000000005 par value |
| (b) | Name of Issuer:
Akari Therapeutics Plc |
| (c) | Address of Issuer's Principal Executive Offices:
401 East Jackson Street, Suite 3300, Tampa,
FLORIDA
, 33602. |
Item 1 Comment:
This Amendment No. 10 to Schedule 13D ("Amendment No. 10") amends and supplements where indicated the Statement on Schedule 13D originally filed with the Securities and Exchange Commission on September 29, 2015 and amended on October 26, 2017, March 30, 2020, October 18, 2021, January 14, 2022, April 14, 2023, October 20, 2023, January 4, 2024, June 20, 2024 and February 14, 2025, respectively (collectively, the "Prior Schedule 13D") by and on behalf of RPC Pharma Limited, a Maltese corporation ("RPC"), Ray Prudo, M.D., a citizen of Canada ("Dr. Prudo") and Praxis Trustees Limited As trustee of The Sonic Healthcare Holding Company ("Praxis," and together with RPC, and Dr. Prudo, the "Reporting Persons"), and relates to the ordinary shares, $0.000000005 par value ("Ordinary Shares") of Akari Therapeutics, Plc, a public limited company formed under the laws of England and Wales (the "Issuer"). The Issuer's American Depositary Shares, each representing 2,000 Ordinary Shares (the "ADSs"), have been registered on a registration statement on Form F-6 (File No. 333-185197), as supplemented (File Nos. 333-234213, 333-262049 and 333-185197), and trade on the Nasdaq Capital Market under the symbol "AKTX." Capitalized terms used herein but not defined herein shall have the meanings ascribed to them in the Prior Schedule 13D. This Amendment No. 10 amends and supplements the Prior Schedule 13D as specifically set forth herein. Except as set forth below, all previous Items in the Prior Schedule 13D remain unchanged. This Amendment No. 10 is being filed to amend Items 3, 4 and 5 as set forth below and to update the number of shares of Ordinary Shares beneficially held by the Reporting Persons as a result of the transaction described below. |
| Item 3. | Source and Amount of Funds or Other Consideration |
| | Item 3 of the Prior Schedule 13D is hereby supplemented by adding the following paragraph:
On December 17, 2025, the Issuer closed a private placement of the Issuer's securities (the "December 2025 PIPE"), pursuant to which, Dr. Prudo purchased 618,658 Series G Warrants to purchase ADSs (representing 1,237,316,000 Ordinary Shares) and 618,658 Pre-Funded Warrants to purchase ADSs (representing 1,237,316,000 Ordinary Shares) at a combined price of $0.4041 per Series G Warrant and Pre-Funded Warrant.
On the same date, the Issuer closed a note cancellation and exchange agreement, pursuant to which, Dr. Prudo purchased 386,661 Note Exchange Warrants to purchase ADSs (representing 773,322,000 Ordinary Shares) and 618,658 Pre-Funded Warrants to purchase ADSs (representing 773,322,000 Ordinary Shares) at a combined price of $0.4041 per Note Exchange Warrant and Pre-Funded Warrant.
The funds used by Dr. Prudo to acquire the ADSs were from his personal funds. |
| Item 4. | Purpose of Transaction |
| | On December 17, 2025, Dr. Prudo purchased the securities described in the transactions as described in Item 3 above. |
| Item 5. | Interest in Securities of the Issuer |
| (a) | Dr. Prudo, either in his individual capacity or as sole manager and member of RPC and Praxis, respectively, beneficially owns an aggregate of (i) 5,163,920,600 shares held of record by Dr. Prudo, (ii) 377,291,667 shares underlying options exercisable within 60 days of March 1, 2026 granted to Dr. Prudo, (iii) 2,010,638,000 shares underlying prefunded warrants exercisable within 60 days of March 1, 2026 (iii) 800,766,600 shares held of record by RPC and (iv) 38,709,600 ordinary shares held of record by Praxis. Excludes up to 5,721,437,500 shares underlying warrants exercisable within 60 days of March 1, 2026 issued to Reporting Person which are subject to a 9.99% beneficial ownership limitation and with respect to which Reporting Person disclaims beneficial ownership to the extent that any exercise of such warrants would exceed such percentage. Reporting Person controls the voting and investment decisions with respect to the shares held of record by RPC and Praxis and thereby may be deemed the beneficial owner of such shares. |
| (b) | See Rows 7 through 11 of cover page for Reporting Persons. |
| (c) | None of the Reporting Persons has effected any transactions in Ordinary Shares during the 60 days prior to the filing of this Amendment No. 10. |
| (d) | No person other than the Reporting Persons is known to have the right to receive or the power to direct the receipt of dividends or the proceeds from the sale of any Ordinary Shares. |
| (e) | Not applicable. |