[Form 4] ALUMIS INC. Insider Trading Activity

Rhea-AI Filing Summary

Alumis Inc. (ALMS) reported an insider share purchase on a Form 4 by a director associated with Samsara investment entities. On 11/20/2025, the reporting person, through Samsara Opportunity Fund, L.P., purchased 125,743 shares of common stock in an open-market transaction at a weighted average price of $7.20 per share, with individual trades occurring between $6.92 and $7.48. Following this transaction, Samsara Opportunity Fund, L.P. was shown as holding 643,260 shares indirectly attributed to the reporting person, and Samsara BioCapital, L.P. was shown as holding an additional 4,491,731 shares indirectly. The reporting person indicates that beneficial ownership of these positions is disclaimed except to the extent of any pecuniary interest.

Insights

Equity Ownership Analyst

Director-related funds increased their indirect stake in Alumis Inc. through open-market common stock purchases at a mid-single-digit price level.

The filing reports that a director-related entity purchased 125,743 shares of Alumis Inc. common stock on 11/20/2025 at a weighted average price of about $7.2, through multiple trades between $6.92 and $7.48. After this transaction, 643,260 shares are held indirectly via Samsara Opportunity Fund, L.P., and 4,491,731 shares are held indirectly via Samsara BioCapital, L.P.. The reporting person has voting and investment power over both funds’ positions but disclaims beneficial ownership beyond their economic interest.

This is an open-market purchase (code "P"), which increases the aggregate indirect holdings associated with the director rather than a sale or option exercise. The structure highlights that exposure is mainly through investment partnerships, so economic interest depends on the reporting person’s stake in those vehicles, which is not quantified here. A useful focus point going forward is whether similar purchases or any sales appear in subsequent Forms 4, and how total fund-held shares evolve over time, especially relative to corporate events or reporting dates.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

AKKARAJU SRINIVAS

(Last) (First) (Middle)

C/O ALUMIS INC.

280 EAST GRAND AVENUE

(Street)

SOUTH SAN FRANCISCO CA 94080

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
ALUMIS INC. [ ALMS ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
11/20/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	11/20/2025		P		125,743	A	$7.2(1)	643,260	I	By Samsara Opportunity Fund, L.P.(2)
Common Stock								4,491,731	I	By Samsara BioCapital, L.P.(3)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $6.92 to $7.48 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

2. Shares are directly held by Samsara Opportunity Fund, L.P. ("Samsara Opportunity Fund"). Samsara Opportunity Fund GP, LLC is the general partner of Samsara Opportunity Fund and may be deemed to beneficially own the securities held by Samsara Opportunity Fund. The Reporting Person has voting and investment power over the shares held by Samsara Opportunity Fund and, accordingly, may be deemed to beneficially own the shares held by Samsara Opportunity Fund. The Reporting Person disclaims beneficial ownership in these securities except to the extent of his pecuniary interest therein.

3. Shares are directly held by Samsara BioCapital LP. ("Samsara LP"). The Reporting Person is a managing member of Samsara BioCapital GP, LLC, the general partner of Samsara LP. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein.

	/s/ Srinivas Akkaraju	11/24/2025
	** Signature of Reporting Person	Date
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