[Form 4] ALUMIS INC. Insider Trading Activity

Rhea-AI Filing Summary

Alumis Inc. (ALMS) director Srinivas Akkaraju reported an indirect purchase of common stock. On 11/13/2025, 276,179 shares of Alumis common stock were acquired at a price of $5.25 per share in a privately negotiated transaction. The shares were purchased by Samsara Opportunity Fund, L.P. from Samsara BioCapital, L.P., both investment entities with which the reporting person is affiliated.

Following this transaction, 276,179 shares are held through Samsara Opportunity Fund, L.P., and 4,491,731 shares are held through Samsara BioCapital, L.P. The filing notes that the transfer between these entities did not change the reporting person’s overall beneficial ownership, and that he disclaims beneficial ownership in these securities except to the extent of his pecuniary interest.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

AKKARAJU SRINIVAS

(Last) (First) (Middle)

C/O ALUMIS INC.

280 EAST GRAND AVENUE

(Street)

SOUTH SAN FRANCISCO CA 94080

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
ALUMIS INC. [ ALMS ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
11/13/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	11/13/2025		P(1)		276,179	A	$5.25	276,179	I	By Samsara Opportunity Fund, L.P.(2)
Common Stock								4,491,731(3)	I	By Samsara BioCapital, L.P.(4)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Represents the purchase of shares from Samsara BioCapital, L.P. ("Samsara LP") in a privately negotiated transaction.

2. Securities are directly held by Samsara Opportunity Fund, L.P. ("Samsara Opportunity Fund"). Samsara Opportunity Fund GP, LLC ("Samsara Opportunity GP") is the general partner of Samsara Opportunity Fund and may be deemed to beneficially own the securities held by Samsara Opportunity Fund. The Reporting Person has voting and investment power over the shares held by Samsara Opportunity Fund and, accordingly, may be deemed to beneficially own the shares held by Samsara Opportunity Fund. The Reporting Person disclaims beneficial ownership in these securities except to the extent of his pecuniary interest therein.

3. The shares held by Samsara LP reflects the disposition of 276,179 shares, to Samsara Opportunity Fund as described in footnote (1), in which the Reporting Person had no pecuniary interest. The transfer of such shares by Samsara LP did not involve a change in the Reporting Person's beneficial ownership of such shares and, accordingly, was exempt from reporting under Section 16.

4. Shares held by Samsara LP. The Reporting Person is a managing member of Samsara BioCapital GP, LLC, the general partner of Samsara LP. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein.

	/s/ Srinivas Akkaraju	11/17/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What insider transaction did Alumis Inc. (ALMS) disclose in this Form 4?

The filing reports that on 11/13/2025, 276,179 shares of Alumis Inc. common stock were acquired at $5.25 per share in a privately negotiated transaction involving entities affiliated with director Srinivas Akkaraju.

Who is the reporting person in the Alumis (ALMS) Form 4 and what is their role?

The reporting person is Srinivas Akkaraju, who is identified in the filing as a director of Alumis Inc. (ALMS).

How many Alumis (ALMS) shares were acquired and at what price?

The transaction shows the acquisition of 276,179 shares of Alumis common stock at a price of $5.25 per share.

Which entities hold the Alumis (ALMS) shares reported in this Form 4?

After the transaction, 276,179 shares are held by Samsara Opportunity Fund, L.P., and 4,491,731 shares are held by Samsara BioCapital, L.P., both of which are affiliated investment entities.

Did the transaction change the director’s overall beneficial ownership of Alumis (ALMS)?

The filing explains that the 276,179-share transfer from Samsara BioCapital, L.P. to Samsara Opportunity Fund, L.P. did not change the reporting person’s overall beneficial ownership and was exempt from Section 16 reporting for that reason.

Does the Alumis (ALMS) director claim full beneficial ownership of the reported shares?

No. The director disclaims beneficial ownership of the shares reported as held by the Samsara entities, except to the extent of his pecuniary interest in those securities.