[Form 4] ALUMIS INC. Insider Trading Activity

Rhea-AI Filing Summary

Alumis Inc. (ALMS) disclosed an insider stock purchase on a Form 4. Investment entities affiliated with Foresite Capital, managed by James B. Tananbaum, reported buying 72,212 shares of Alumis common stock on 11/21/2025 in an open-market transaction coded "P" at a price of $7.38 per share.

After this trade, one reporting entity, Foresite Capital Opportunity Fund V, L.P., is shown as indirectly beneficially owning 2,614,215 shares of Alumis common stock, with additional indirect holdings reported through other Foresite-managed funds. The reporting persons state that each investment vehicle and manager disclaims being part of a group and disclaims beneficial ownership of shares held by the other funds beyond their economic interest.

Insights

Equity Ownership and Governance Analyst

Large existing shareholder group indirectly acquired more ALUMIS stock, modestly increasing an already concentrated, fund-controlled ownership position.

The disclosure shows affiliated Foresite Capital entities, treated as indirect holders, acquired 72,212 shares of ALUMIS INC. common stock on 11/21/2025 at a price of $7.38 per share. The position reported in that acquiring entity rose to 2,614,215 shares held indirectly, alongside several other existing indirect blocks of 4,247,670, 5,584,889, 194,459, 1,960,337 and 1,176,470 shares held through related funds and vehicles.

Control of these positions runs through multiple limited partnerships and LLCs, with general partners and managing members such as Foresite Capital Opportunity Fund V, L.P., Foresite Capital Fund V, L.P., Foresite Capital Fund VI, L.P., and various Foresite Labs vehicles. The disclosure describes these parties as having voting and dispositive power via general partner or managing member roles, while expressly disclaiming group status under Rule 13d‑5 and beneficial ownership beyond pecuniary interests. This structure concentrates influence but also clarifies legal responsibility chains.

The key practical takeaway is that a director and reported 10% owner, through these funds, increased exposure via a relatively small incremental purchase compared with existing multi‑million‑share holdings. Attention naturally centers on any future Form 4s connected to these same entities and the referenced parallel Form 4s filed on 11/25/2025, since together they outline the pace and direction of ownership changes by this sponsor group over the near term.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Foresite Capital Management VI LLC

(Last) (First) (Middle)

900 LARKSPUR LANDING CIRCLE

SUITE 150

(Street)

LARKSPUR CA 94939

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
ALUMIS INC. [ ALMS ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
11/21/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

	Form filed by One Reporting Person
X	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	11/21/2025		P		72,212	A	$7.38	2,614,215	I	See Footnote(1)
Common Stock								4,247,670	I	See Footnote(2)
Common Stock								5,584,889	I	See Footnote(3)
Common Stock								194,459	I	See Footnote(4)
Common Stock								1,960,337	I	See Footnote(5)
Common Stock								1,176,470	I	See Footnote(6)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

1. Name and Address of Reporting Person^*

Foresite Capital Management VI LLC

(Last) (First) (Middle)

900 LARKSPUR LANDING CIRCLE

SUITE 150

(Street)

LARKSPUR CA 94939

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Foresite Capital Management V, LLC

(Last) (First) (Middle)

900 LARKSPUR LANDING CIRCLE

SUITE 150

(Street)

LARKSPUR CA 94939

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Foresite Capital Fund V, L.P.

(Last) (First) (Middle)

900 LARKSPUR LANDING CIRCLE

SUITE 150

(Street)

LARKSPUR CA 94939

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Foresite Capital Opportunity Management V, LLC

(Last) (First) (Middle)

900 LARKSPUR LANDING CIRCLE

SUITE 150

(Street)

LARKSPUR CA 94939

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Foresite Capital Opportunity Fund V, L.P.

(Last) (First) (Middle)

900 LARKSPUR LANDING CIRCLE

SUITE 150

(Street)

LARKSPUR CA 94939

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Foresite Capital Fund VI LP

(Last) (First) (Middle)

900 LARKSPUR LANDING CIRCLE

SUITE 150

(Street)

LARKSPUR CA 94939

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Labs Co-Invest V, LLC

(Last) (First) (Middle)

900 LARKSPUR LANDING CIRCLE

SUITE 150

(Street)

LARKSPUR CA 94939

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Foresite Labs Management I, LLC

(Last) (First) (Middle)

900 LARKSPUR LANDING CIRCLE

SUITE 150

(Street)

LARKSPUR CA 94939

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Foresite Labs Fund I, L.P.

(Last) (First) (Middle)

900 LARKSPUR LANDING CIRCLE

SUITE 150

(Street)

LARKSPUR CA 94939

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

Explanation of Responses:

1. The shares are held of record by Foresite Capital Opportunity Fund V, L.P. ("Opportunity Fund V"). Foresite Capital Opportunity Management V, LLC ("FCOM V") is the general partner of Opportunity Fund V and may be deemed to have sole voting and dispositive power over such shares. James B. Tananbaum ("Tananbaum"), the managing member of FCOM V, may be deemed to have sole voting and dispositive power over such shares. Each of the Reporting Persons disclaims the existence of a "group", as defined in Rule 13d-5 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and, other than Opportunity Fund V, disclaims beneficial ownership of the shares held by Opportunity Fund V, except to the extent of such person's pecuniary interest in such securities.

2. The shares are held of record by Foresite Capital Fund VI, L.P. ("Fund VI"). Foresite Capital Management VI, LLC ("FCM VI") is the general partner of Fund VI and may be deemed to have sole voting and dispositive power over such shares. Tananbaum, the managing member of FCM VI, may be deemed to have sole voting and dispositive power over such shares. Each of the Reporting Persons disclaims the existence of a "group", as defined in Rule 13d-5 of the Exchange Act, and, other than Fund VI, disclaims beneficial ownership of the shares held by Fund VI, except to the extent of such person's pecuniary interest in such securities.

3. The shares are held of record by Foresite Capital Fund V, L.P. ("Fund V"). Foresite Capital Management V, LLC ("FCM V") is the general partner of Fund V and may be deemed to have sole voting and dispositive power over such shares. Tananbaum, the managing member of FCM V, may be deemed to have sole voting and dispositive power over such shares. Each of the Reporting Persons disclaims the existence of a "group", as defined in Rule 13d-5 of the Exchange Act, and, other than Fund V, disclaims beneficial ownership of the shares held by Fund V, except to the extent of such person's pecuniary interest in such securities.

4. The shares are held of record by Labs Co-Invest V, LLC ("Labs Co-Invest"). FCM V is the managing member of Labs Co-Invest and may be deemed to have sole voting and dispositive power over such shares. Tananbaum, the managing member of FCM V, may be deemed to have sole voting and dispositive power over such shares. Each of the Reporting Persons disclaims the existence of a "group", as defined in Rule 13d-5 of the Exchange Act, and, other than Labs Co-Invest, disclaims beneficial ownership of the shares held by Labs Co-Invest, except to the extent of such person's pecuniary interest in such securities.

5. The shares are held of record by Foresite Labs Fund I, L.P. ("Labs Fund I"). Foresite Labs Management I, LLC ("FLM I") is the general partner of Labs Fund I and may be deemed to have sole voting and dispositive power over such shares. Tananbaum, the managing member of FLM I, may be deemed to have sole voting and dispositive power over such shares. Each of the Reporting Persons disclaims the existence of a "group", as defined in Rule 13d-5 of the Exchange Act, and, other than Labs Fund I, disclaims beneficial ownership of the shares held by Labs Fund I, except to the extent of such person's pecuniary interest in such securities.

6. The shares are held of record by Foresite Labs Affiliates 2021, LLC ("Labs Affiliates"). Foresite Labs, LLC ("Labs") is the managing member of Labs Affiliates and may be deemed to have sole voting and dispositive power over such shares. Tananbaum, a manager of Labs, may be deemed to share voting and dispositive power over such shares. Each of the Reporting Persons disclaims the existence of a "group", as defined in Rule 13d-5 of the Exchange Act, and, other than Lab Affiliates, disclaims beneficial ownership of the shares held by Labs Affiliates, except to the extent of such person's pecuniary interest in such securities.

Remarks:

This Form 4 is one of three Form 4s filed on the date hereof in respect of these transactions. The Reporting Persons for the other Form 4s are Tananbaum, Labs Affiliates and Labs.

	FORESITE CAPITAL MANAGEMENT V, LLC, By: /s/ James B. Tananbaum, Managing Member	11/25/2025
	FORESITE CAPITAL FUND V, L.P., By: Foresite Capital Management V, LLC, Its: General Partner, By: /s/ James B. Tananbaum, Managing Member	11/25/2025
	FORESITE CAPITAL OPPORTUNITY MANAGEMENT V, LLC, By: /s/ James B. Tananbaum, Managing Member	11/25/2025
	FORESITE CAPITAL OPPORTUNITY FUND V, L.P., By: Foresite Capital Opportunity Management V, LLC, Its: General Partner, By: /s/ James B. Tananbaum, Managing Member	11/25/2025
	FORESITE CAPITAL MANAGEMENT VI, LLC, By: /s/ James B. Tananbaum, Managing Member	11/25/2025
	FORESITE CAPITAL FUND VI, L.P., By: Foresite Capital Management VI, LLC, Its: General Partner, By: /s/ James B. Tananbaum, Managing Member	11/25/2025
	LABS CO-INVEST V, LLC, By: Foresite Capital Management V, LLC, Its: Managing Member, By: /s/ James B. Tananbaum, Managing Member	11/25/2025
	FORESITE LABS MANAGEMENT I, LLC, By: /s/ James B. Tananbaum, Managing Member	11/25/2025
	FORESITE LABS FUND I, L.P., By: Foresite Labs Management I, LLC, Its: General Partner, By: /s/ James B. Tananbaum, Managing Member	11/25/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What insider transaction did Alumis (ALMS) report on this Form 4?

The filing reports that Foresite-affiliated entities purchased 72,212 shares of Alumis Inc. common stock on 11/21/2025 in an open-market transaction coded "P".

At what price were the Alumis (ALMS) shares purchased by the insider group?

The reported insider purchase was made at a price of $7.38 per share for Alumis common stock.

Who are the reporting persons on this Alumis (ALMS) Form 4?

The reporting persons are Foresite Capital investment entities, including Foresite Capital Opportunity Fund V, L.P., Foresite Capital Fund V, L.P., Foresite Capital Fund VI, L.P., and related Labs funds, with James B. Tananbaum serving as managing member of their general partners or managers.

How many Alumis (ALMS) shares are indirectly owned after the transaction?

Following the reported trade, Foresite Capital Opportunity Fund V, L.P. is shown as indirectly beneficially owning 2,614,215 shares of Alumis common stock, with separate additional indirect holdings shown for other Foresite-managed funds.

What is the relationship of the reporting persons to Alumis (ALMS)?

The reporting person is indicated as a director of Alumis Inc., with the Alumis relationship section marking the reporting person as a director of the issuer.

What do the Form 4 footnotes say about group status and ownership for Alumis (ALMS)?

The footnotes state that each reporting person disclaims the existence of a "group" under Rule 13d-5 and, other than the specific fund that directly holds the shares, disclaims beneficial ownership of shares held by the other funds except to the extent of their pecuniary interest.

Which entities hold the reported Alumis (ALMS) shares of record?

The shares are held of record by several Foresite-affiliated vehicles, including Foresite Capital Opportunity Fund V, L.P., Foresite Capital Fund V, L.P., Foresite Capital Fund VI, L.P., Labs Co-Invest V, LLC, Foresite Labs Fund I, L.P., and Foresite Labs Affiliates 2021, LLC, each with its own general partner or managing entity.