Alnylam director Pyott exercises 3,780 stock options

Available on EDGAR 11/12/2026 - 04:09 PM EST Accepted by SEC EDGAR 11/12/2026 - 04:07 PM EST Learn about SEC filing dates

Rhea-AI Filing Summary

Alnylam Pharmaceuticals, Inc. (ALNY) director David E. I. Pyott exercised options on November 10, 2026, to acquire 3,780 common shares at a $71.99 exercise price. His direct common-stock holdings were 5,362 shares after the exercise. Separately, the David E I Pyott Trust held 27,900 ALNY shares; Pyott is the trust’s trustee. The options were due to expire June 1, 2027.

Insider Trade Summary

3,780 shares exercised/converted

Exercise 2 txns

Insider PYOTT DAVID E I

Role Director

Type	Security	Shares	Price	Value
Exercise	Stock Option (Right to Buy) F1	3,780	$0.00	$0.00
Exercise	Common Stock F1	3,780	$71.99	$272K
Holding	Common Stock F2	--	--	--

Holdings After Transaction: Stock Option (Right to Buy) — 0 options (Direct); Common Stock — 5,362 shares (Direct); Common Stock — 27,900 shares (Indirect, by Trust)

Footnotes (2)

1. F1. The options exercised and held by the reporting person were due to expire on June 1, 2027.
2. F2. The shares of ALNY common stock were purchased by the David E I Pyott Trust, of which the reporting person is trustee.

Key Figures

Common shares acquired through option exercise: 3,780 shares Exercise price: $71.99 per share Direct common shares after exercise: 5,362 shares +2 more

5 metrics

Common shares acquired through option exercise 3,780 shares November 10, 2026

Exercise price $71.99 per share Options exercised November 10, 2026

Direct common shares after exercise 5,362 shares Reported after the November 10, 2026 exercise

Trust-held common shares 27,900 shares Held by the David E I Pyott Trust; Pyott is its trustee

Option expiration June 1, 2027 The exercised options were due to expire on this date

Key Terms

Stock Option (Right to Buy), exercise price

2 terms

Stock Option (Right to Buy) technical

"Stock Option (Right to Buy)"

exercise price financial

"at a $71.99 exercise price"

The exercise price is the fixed amount at which you can buy or sell an asset, like a stock, when using an options contract. It matters because it helps determine whether exercising the option will be profitable or not, depending on the current market price. Think of it as the set price you agree on today to buy or sell later.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many ALNY shares did director David E. I. Pyott acquire by exercising options?

David E. I. Pyott exercised options to acquire 3,780 ALNY common shares at a $71.99 exercise price on November 10, 2026. His direct holdings afterward were 5,362 common shares.

AI-generated analysis. How Rhea-AI works. Not financial advice.

Form 4 Insider Transactions: What Each Field Means →

See more from StockTitan in Google Search and AI answers. Adds StockTitan as a preferred source · opens Google

Add on Google Not now

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

PYOTT DAVID E I

(Last) (First) (Middle)

675 WEST KENDALL STREET

(Street)

CAMBRIDGE MASSACHUSETTS 02142

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
ALNYLAM PHARMACEUTICALS, INC. [ ALNY ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
11/10/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	11/10/2026		M(1)		3,780	A	$71.99	5,362	D
Common Stock								27,900	I	by Trust(2)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	$71.99	11/10/2026		M(1)			3,780	06/02/2018	06/01/2027	Common Stock	3,780	$0	0	D

Explanation of Responses:

1. The options exercised and held by the reporting person were due to expire on June 1, 2027.

2. The shares of ALNY common stock were purchased by the David E I Pyott Trust, of which the reporting person is trustee.

	Brett Budzinski, Attorney-in-Fact For: David E.I. Pyott	11/12/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)