BlackRock, Inc. (ANNX) reports 8.0% beneficial stake in Annexon common stock

Rhea-AI Filing Summary

BlackRock, Inc. reports beneficial ownership of common stock of ANNEXON INC. BlackRock and certain of its subsidiaries and affiliates collectively hold 13,128,281 shares, representing 8.0% of Annexon’s outstanding common stock.

BlackRock has sole voting power over 12,900,823 shares and sole dispositive power over 13,128,281 shares, with no shared voting or dispositive power. Various underlying clients have the right to receive dividends or sale proceeds from these shares, but no single such person is reported to hold more than five percent of Annexon’s total outstanding common shares. The filing is signed by a Managing Director of BlackRock.

Key Figures

Beneficial ownership: 13,128,281 shares Percent of class: 8.0% Sole voting power: 12,900,823 shares +2 more

5 metrics

Beneficial ownership 13,128,281 shares Common stock of Annexon Inc. beneficially owned by BlackRock, Inc.

Percent of class 8.0% Portion of Annexon Inc. common stock class held by BlackRock, Inc.

Sole voting power 12,900,823 shares Shares over which BlackRock, Inc. has sole power to vote or direct the vote

Sole dispositive power 13,128,281 shares Shares over which BlackRock, Inc. has sole power to dispose or direct disposition

Form date 06/30/2026 Date associated with the Schedule 13G/A reporting Annexon ownership

Key Terms

beneficially owned, Sole Voting Power, Sole Dispositive Power, parent holding company, +1 more

5 terms

beneficially owned financial

"reflects the securities beneficially owned, or deemed to be beneficially owned, by certain business units"

Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.

Sole Voting Power financial

"5 | Sole Voting Power 12,900,823.00 6 | Shared Voting Power 0.00"

Sole voting power is the exclusive right to cast votes attached to a shareholder’s stock without needing approval from anyone else. Like holding the only remote control for a TV, it lets that holder decide corporate matters such as board members, mergers, and policy changes, making it important to investors because it concentrates control and can strongly influence a company’s strategy and the value of its shares.

Sole Dispositive Power financial

"7 | Sole Dispositive Power 13,128,281.00 8 | Shared Dispositive Power 0.00"

Sole dispositive power is the exclusive legal authority to decide what happens to a security — for example, whether to sell, transfer, or retain shares — without needing anyone else’s permission. Investors care because it signals who truly controls the economic outcome of an investment: like holding the only key to a safe, the holder can realize gains or losses and may trigger regulatory reporting, insider rules, or influence over corporate ownership.

parent holding company financial

"Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company"

Schedule 13G regulatory

"In accordance with SEC Release No. 34-39538 (January 12, 1998), this reflects the securities"

A Schedule 13G is a formal document that investors file with the government when they acquire a large ownership stake in a company, usually for investment purposes rather than control. It helps keep the public informed about who owns significant parts of a company's shares, which can influence how the company is managed and how investors make decisions. Filing this schedule is important for transparency and understanding the ownership landscape of publicly traded companies.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 07/27/2026 - 04:26 PM Accepted by SEC EDGAR 07/27/2026 - 04:25 PM Learn about SEC filing dates

FAQ

How many ANNX shares does BlackRock, Inc. report owning in this Schedule 13G/A?

BlackRock, Inc. reports beneficial ownership of 13,128,281 shares of Annexon Inc. common stock. This position is held through certain BlackRock business units and subsidiaries, which collectively manage these securities on behalf of underlying clients.

What percentage of Annexon Inc. (ANNX) does BlackRock, Inc. beneficially own?

BlackRock, Inc. reports beneficial ownership of 8.0% of Annexon Inc.’s outstanding common stock. This percentage reflects the aggregate holdings of specified BlackRock business units and affiliates as disclosed in the Schedule 13G/A amendment.

What voting power does BlackRock, Inc. report over ANNX shares?

BlackRock, Inc. reports sole voting power over 12,900,823 Annexon shares and no shared voting power. This means those BlackRock entities alone can vote or direct the vote on that number of shares in Annexon Inc.

What dispositive power does BlackRock, Inc. have over its Annexon (ANNX) holdings?

BlackRock, Inc. reports sole dispositive power over 13,128,281 Annexon shares and no shared dispositive power. Sole dispositive power covers the ability to dispose of or direct the disposition of these shares.

Do any individual BlackRock clients own more than 5% of Annexon Inc. (ANNX)?

No. The filing states that various persons have rights to dividends or sale proceeds from Annexon stock, but no one person’s interest exceeds five percent of Annexon’s total outstanding common shares, based on BlackRock’s knowledge.

Who is the reporting person and how is the Annexon (ANNX) stake structured?

The reporting person is BlackRock, Inc., a Delaware entity. The disclosed Annexon stake represents securities beneficially owned or deemed owned by certain BlackRock business units, with other disaggregated units excluded per SEC Release No. 34-39538.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 2)

ANNEXON INC

(Name of Issuer)

Common Stock

(Title of Class of Securities)

03589W102

(CUSIP Number)

06/30/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 03589W102

1

Names of Reporting Persons

BlackRock, Inc.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 12,900,823.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 13,128,281.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

13,128,281.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

8.0 %

12

Type of Reporting Person (See Instructions)

HC

SCHEDULE 13G

Item 1.
(a)	Name of issuer: ANNEXON INC
(b)	Address of issuer's principal executive offices: 1400 SIERRA POINT PARKWAY, BLDG C SUITE 200 Brisbane CA 94005
Item 2.
(a)	Name of person filing: BlackRock, Inc. In accordance with SEC Release No. 34-39538 (January 12, 1998), this Schedule 13G reflects the securities beneficially owned, or deemed to be beneficially owned, by certain business units (collectively, the "Reporting Business Units") of BlackRock, Inc. and its subsidiaries and affiliates. It does not include securities, if any, beneficially owned by other business units whose beneficial ownership of securities are disaggregated from that of the Reporting Business Units in accordance with such release.
(b)	Address or principal business office or, if none, residence: BlackRock, Inc., 50 Hudson Yards New York, NY 10001
(c)	Citizenship: See Item 4 of Cover Page
(d)	Title of class of securities: Common Stock
(e)	CUSIP No.: 03589W102
Item 4.	Ownership
(a)	Amount beneficially owned: 13128281
(b)	Percent of class: 8.0 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 12900823
	(ii) Shared power to vote or to direct the vote: 0
	(iii) Sole power to dispose or to direct the disposition of: 13128281
	(iv) Shared power to dispose or to direct the disposition of: 0
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. Various persons have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of the common stock of ANNEXON INC. No one person's interest in the common stock of ANNEXON INC is more than five percent of the total outstanding common shares.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. See Exhibit 99
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

BlackRock, Inc.

Signature:	Spencer Fleming
Name/Title:	Managing Director
Date:	07/27/2026

Exhibit Information

Exhibit 24: Power of Attorney Exhibit 99: Item 7