Annexon, Inc. ownership disclosure: Redmile Group, LLC and affiliated persons report beneficial ownership stakes in the company's common stock as of July 8, 2026. Redmile Group and Jeremy C. Green each report 17,918,459 shares (representing 9.9% of the class) including warrants, and RedCo II Offshore SPV LLC reports 9,802,458 shares (representing 5.5%).
The filing states these totals include 3,369,563 shares issuable upon exercise of pre-funded warrants and cites 163,842,538 shares outstanding as of May 4, 2026 plus 15,521,422 shares issuable under the warrants for percentage calculation. The disclosure adds RedCo II Offshore SPV LLC as a reporting person after it crossed the 5% threshold.
Positive
None.
Negative
None.
Insights
Redmile reports near-10% stake led by shared voting/dispositive power.
Redmile Group and Jeremy C. Green report 17,918,459 shares beneficially owned, including 3,369,563 shares issuable under pre-funded warrants subject to a 9.99% Beneficial Ownership Limitation. The filing attributes voting and dispositive power to Redmile and Mr. Green in their capacity as manager and principal.
The percentage base uses 163,842,538 shares outstanding as of May 4, 2026 plus 15,521,422 warrant-issuable shares. Subsequent filings may clarify any changes; cash-flow treatment is not stated in the excerpt.
Filing adds a subsidiary reporting person after surpassing 5% ownership.
The amendment notes the addition of RedCo II Offshore SPV LLC as a reporting person following its acquisition of more than 5% of common stock. RedCo II Offshore is shown with 9,802,458 shares and shared voting/dispositive power.
Beneficial-ownership disclaimers are included: Redmile and Mr. Green disclaim beneficial ownership except for pecuniary interest. Investors should track future amendments for changes in holdings or voting arrangements.
Key Figures
Redmile beneficial ownership:17,918,459 sharesJeremy C. Green beneficial ownership:17,918,459 sharesRedCo II Offshore beneficial ownership:9,802,458 shares+3 more
6 metrics
Redmile beneficial ownership17,918,459 sharesreported as of July 8, 2026
Jeremy C. Green beneficial ownership17,918,459 sharesreported as of July 8, 2026
RedCo II Offshore beneficial ownership9,802,458 sharesreported as of July 8, 2026
Warrants issuable3,369,563 sharespre-funded warrants held by Redmile funds (included in totals)
Shares outstanding basis163,842,538 sharesoutstanding as of May 4, 2026 (used for percentage)
Warrant-issuable shares included in base15,521,422 sharesshares issued and issuable under warrants for percentage calculation
Key Terms
Beneficial Ownership Limitation, pre-funded warrants, shared dispositive power
3 terms
Beneficial Ownership Limitationregulatory
"the maximum number of shares...subject to the 9.99% beneficial ownership limitation"
A beneficial ownership limitation is a rule that caps the percentage of a company’s shares an investor can be treated as owning or controlling for voting, regulatory or tax purposes. It matters to investors because it can restrict how many shares a person or group can buy or vote, affect takeover chances, and influence share liquidity and value — like a speed limit that prevents any single driver from taking over the whole road.
pre-funded warrantsfinancial
"shares of Common Stock issuable upon exercise of the Warrants reported as beneficially owned"
Pre-funded warrants are financial instruments that give investors the right to purchase a company's stock at a set price, but with most or all of the purchase price paid upfront. They function like a coupon or gift card for stock, allowing investors to buy shares later at a fixed price, which can be beneficial if they want to avoid future price increases. This makes them important for investors seeking flexibility and certainty in their investment plans.
Redmile Group reports 17,918,459 shares, representing 9.9% of ANNX common stock, including shares issuable upon exercise of pre-funded warrants, as stated in the amendment dated July 8, 2026.
How many shares does RedCo II Offshore SPV LLC report for ANNX?
RedCo II Offshore SPV LLC reports 9,802,458 shares, representing 5.5% of the class, based on the filing's calculation using the issuer's outstanding share base and warrant-issuable shares.
What warrants are included in the reported holdings?
The report states 3,369,563 shares are issuable upon exercise of pre-funded warrants held by the Redmile funds; these are included in the beneficial ownership totals subject to a 9.99% Beneficial Ownership Limitation.
What share count did the filing use to calculate percentages?
Percentages are calculated using 163,842,538 shares outstanding as of May 4, 2026 plus 15,521,422 shares issued and issuable under the warrants directly held by the Redmile funds, per the amendment.
Does the filing state who controls voting or disposition of the shares?
The filing attributes shared voting and shared dispositive power over the reported shares to Redmile Group and Jeremy C. Green, reflecting their roles as investment manager and principal respectively.
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
UNDER THE SECURITIES EXCHANGE ACT OF 1934
(Amendment No. 6)
Annexon, Inc.
(Name of Issuer)
Common Stock, par value $0.001 per share
(Title of Class of Securities)
03589W102
(CUSIP Number)
07/01/2026
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Rule 13d-1(b)
Rule 13d-1(c)
Rule 13d-1(d)
schemaVersion:
SCHEDULE 13G
CUSIP Number(s):
03589W102
1
Names of Reporting Persons
Redmile Group, LLC
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
17,918,459.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
17,918,459.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
17,918,459.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
9.9 %
12
Type of Reporting Person (See Instructions)
IA, OO
Comment for Type of Reporting Person: Reported information current as of July 8, 2026.
The information in Item 4 relating to the shares of the Issuer's common stock ("Common Stock") that are or may be deemed beneficially owned by Redmile Group, LLC ("Redmile") is incorporated herein by reference.
SCHEDULE 13G
CUSIP Number(s):
03589W102
1
Names of Reporting Persons
Jeremy C. Green
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
UNITED KINGDOM
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
17,918,459.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
17,918,459.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
17,918,459.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
9.9 %
12
Type of Reporting Person (See Instructions)
HC, IN
Comment for Type of Reporting Person: Reported information current as of July 8, 2026.
The information in Item 4 relating to the shares of Common Stock that are or may be deemed beneficially owned by Jeremy C. Green is incorporated herein by reference.
SCHEDULE 13G
CUSIP Number(s):
03589W102
1
Names of Reporting Persons
RedCo II Offshore SPV LLC
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
CAYMAN ISLANDS
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
9,802,458.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
9,802,458.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
9,802,458.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
5.5 %
12
Type of Reporting Person (See Instructions)
FI, OO
Comment for Type of Reporting Person: Reported information current as of July 8, 2026.
The information in Item 4 relating to the shares of Common Stock that are or may be deemed beneficially owned by RedCo II Offshore SPV LLC is incorporated herein by reference.
SCHEDULE 13G
Item 1.
(a)
Name of issuer:
Annexon, Inc.
(b)
Address of issuer's principal executive offices:
1400 Sierra Point Parkway, Bldg C, Suite 200, Brisbane, CA 94005
Item 2.
(a)
Name of person filing:
Redmile Group, LLC
Jeremy C. Green
RedCo II Offshore SPV LLC *
* This amendment No. 6 reports the addition of RedCo II Offshore SPV LLC as a reporting person in this jointly filed Schedule 13G following its initial acquisition of more than 5% of the Issuer's outstanding common stock as of July 1, 2026.
(b)
Address or principal business office or, if none, residence:
Redmile Group, LLC
900 Larkspur Landing Circle, Suite 270
Larkspur, California 94939
Jeremy C. Green
c/o Redmile Group, LLC (NY Office)
45 W. 27th Street, Floor 11
New York, NY 10001
RedCo II Offshore SPV LLC
c/o Redmile Group, LLC
900 Larkspur Landing Circle, Suite 270
Larkspur, California 94939
(c)
Citizenship:
Redmile Group, LLC: Delaware
Jeremy C. Green: United Kingdom
RedCo II Offshore SPV LLC: Cayman Islands
(d)
Title of class of securities:
Common Stock, par value $0.001 per share
(e)
CUSIP No.:
03589W102
Item 3.
If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)
Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)
Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)
Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)
Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)
An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)
An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)
A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)
A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)
A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
please specify the type of institution:
(k)
Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.
Ownership
(a)
Amount beneficially owned:
Redmile Group, LLC - 17,918,459 (1)
Jeremy C. Green - 17,918,459 (1)
RedCo II Offshore SPV LLC - 9,802,458 (2)
(b)
Percent of class:
Redmile Group, LLC - 9.9%
Jeremy C. Green - 9.9%
RedCo II Offshore SPV LLC - 5.5%
(c)
Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote:
Redmile Group, LLC - 0
Jeremy C. Green - 0
RedCo II Offshore SPV LLC - 0
(ii) Shared power to vote or to direct the vote:
Redmile Group, LLC - 17,918,459 (1)
Jeremy C. Green - 17,918,459 (1)
RedCo II Offshore SPV LLC - 9,802,458 (2)
(iii) Sole power to dispose or to direct the disposition of:
Redmile Group, LLC - 0
Jeremy C. Green - 0
RedCo II Offshore SPV LLC - 0
(iv) Shared power to dispose or to direct the disposition of:
Redmile Group, LLC - 17,918,459 (1)
Jeremy C. Green - 17,918,459 (1)
RedCo II Offshore SPV LLC - 9,802,458 (2)
(1) As of July 8, 2026, Redmile's and Jeremy C. Green's beneficial ownership of the Issuer's Common Stock is comprised of (i) 14,548,896 shares of Common Stock and (ii) 3,369,563 shares of Common Stock issuable upon exercise of certain pre-funded warrants to purchase Common Stock (the "Warrants").
The shares of Common Stock issuable upon exercise of the Warrants reported as beneficially owned by the Reporting Persons represent the maximum number of shares of Common Stock that could be issued upon exercise of those Warrants subject to the 9.99% beneficial ownership limitation (the "Beneficial Ownership Limitation"). All of such shares of Common Stock and the Warrants are directly owned by certain investment vehicles, including RedCo II Offshore SPV LLC ("RedCo II Offshore"), for which Redmile is the investment manager (the "Redmile Funds"). Redmile may be deemed to beneficially own these securities in its capacity as their investment manager with discretion to vote and dispose of all shares of Common Stock held by the Redmile Funds. Mr. Green also may be deemed to beneficially own these securities as the principal of Redmile. Redmile and Mr. Green each disclaims beneficial ownership of these securities, except to the extent of its or his pecuniary interest in such securities, if any.
(2) As of July 8, 2026, RedCo II Offshore may be deemed to beneficially own (i) 6,432,895 shares of Common Stock, and (ii) 3,369,563 shares of Common Stock issuable upon exercise of the Warrants directly held by RedCo II Offshore.
The shares of Common Stock issuable upon exercise of the Warrants reported as beneficially owned by RedCo II Offshore represent the maximum number of shares of Common Stock that could be issued to RedCo II Offshore upon exercise of those Warrants subject to the Beneficial Ownership Limitation.
Percentage based on: (i) 163,842,538 shares of Common Stock outstanding as of May 4, 2026, as reported by the Issuer in its Form 10-Q for the quarterly period ended March 31, 2026 filed with the SEC on May 7, 2026; plus (ii) 15,521,422 shares of Common Stock issued and, under the Beneficial Ownership Limitation, issuable upon exercise of the Warrants directly held by the Redmile Funds (including RedCo II Offshore).
Item 5.
Ownership of 5 Percent or Less of a Class.
Not Applicable
Item 6.
Ownership of more than 5 Percent on Behalf of Another Person.
Not Applicable
Item 7.
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary.
See the response to Item 4.
Item 8.
Identification and Classification of Members of the Group.
Not Applicable
Item 9.
Notice of Dissolution of Group.
Not Applicable
Item 10.
Certifications:
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
Redmile Group, LLC
Signature:
/s/ Jeremy C. Green
Name/Title:
Managing Member
Date:
07/08/2026
Jeremy C. Green
Signature:
/s/ Jeremy C. Green
Name/Title:
Jeremy C. Green
Date:
07/08/2026
RedCo II Offshore SPV LLC
Signature:
/s/ Jeremy C. Green
Name/Title:
Managing Member of Redmile Group, LLC, its manager
