State Street reports 5.4% stake in Apellis

State Street Corporation reported passive ownership of Apellis Pharmaceuticals common stock.

Rhea-AI Filing Summary

State Street Corporation reported passive ownership of Apellis Pharmaceuticals common stock. On 03/31/2026 State Street disclosed 6,845,031 shares beneficially owned, representing 5.4% of the class. The filing shows shared voting power of 6,603,712 and shared dispositive power of 6,845,031. The report lists multiple State Street-related entities that hold the position and was signed on 05/12/2026 by Elizabeth Schaefer, Senior Vice President and Chief Accounting Officer.

Insights

Institutional Ownership Analyst

State Street holds a passive >5% stake in Apellis as of 03/31/2026.

State Street Corporation reports beneficial ownership of 6,845,031 shares (5.4%) with shared voting power of 6,603,712. The position is held through multiple State Street affiliates named in the schedule.

The ownership is typical of asset managers and is presented as passive; governance influence depends on how voting power is exercised by the listed entities in future disclosures.

Corporate Governance Specialist

Filing clarifies power allocation across State Street entities; investors should note the allocation.

The schedule specifies no sole voting or dispositive power and lists affiliates such as SSGA Funds Management and State Street Bank and Trust Company. This indicates collective control via institutional vehicles rather than individual discretion.

Subsequent 13D/13G or Form 4 filings could show changes; this schedule is a snapshot as of 03/31/2026.

Key Figures

Filing date reference: 03/31/2026 Beneficially owned shares: 6,845,031 shares Percent of class: 5.4% +3 more

6 metrics

Filing date reference 03/31/2026 ownership reported as of this date

Beneficially owned shares 6,845,031 shares Amount beneficially owned reported on Schedule 13G

Percent of class 5.4% Percent of common stock beneficially owned

Shared voting power 6,603,712 shares Number with shared power to vote

Shared dispositive power 6,845,031 shares Number with shared power to dispose

Signees and attestation date 05/12/2026 Signature date by Elizabeth Schaefer, SVP and CAO

Key Terms

Schedule 13G, Shared dispositive power, Investment Adviser (IA), Sole voting power

4 terms

Schedule 13G regulatory

"Item 1. (a) Name of issuer: APELLIS PHARMACEUTICALS INC"

A Schedule 13G is a formal document that investors file with the government when they acquire a large ownership stake in a company, usually for investment purposes rather than control. It helps keep the public informed about who owns significant parts of a company's shares, which can influence how the company is managed and how investors make decisions. Filing this schedule is important for transparency and understanding the ownership landscape of publicly traded companies.

Shared dispositive power regulatory

"Item 4. (c)(iv) Shared power to dispose or to direct the disposition of: 6,845,031"

Investment Adviser (IA) financial

"SSGA FUNDS MANAGEMENT, INC. (IA); STATE STREET GLOBAL ADVISORS LIMITED (IA)"

An investment adviser (IA) is a person or firm that provides personalized guidance on buying, selling, or holding investments and often manages client portfolios for a fee. Investors should care because an IA has a legal duty to act in the client's best interest—think of them as a navigator who plans and steers your financial journey—so their advice, fee structure and potential conflicts can directly affect returns and financial risk.

Sole voting power regulatory

"Item 4. (c)(i) Sole power to vote or to direct the vote: 0"

Sole voting power is the exclusive right to cast votes attached to a shareholder’s stock without needing approval from anyone else. Like holding the only remote control for a TV, it lets that holder decide corporate matters such as board members, mergers, and policy changes, making it important to investors because it concentrates control and can strongly influence a company’s strategy and the value of its shares.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What stake does State Street (APLS) report owning?

State Street reports beneficial ownership of 6,845,031 shares, equal to 5.4% of Apellis common stock as of 03/31/2026. The schedule lists shared voting and dispositive power across State Street affiliates.

Does State Street have sole voting control over APLS shares?

No. The filing shows 0 shares with sole voting power and 6,603,712 shares with shared voting power, indicating voting is exercised collectively by State Street entities.

Which State Street entities are named in the 13G for APLS?

The schedule names affiliates including SSGA Funds Management, Inc., State Street Bank and Trust Company, and multiple State Street Global Advisors entities as holders of the reported position.

What is the reporting date and signature date on the Schedule 13G?

The ownership position is stated as of 03/31/2026 and the filing is signed by Elizabeth Schaefer on 05/12/2026, providing the official attestation date for the disclosed information.

Is the reported ownership classified as passive or active?

The filing is a Schedule 13G, which is used for certain passive or qualifying institutional investors; the schedule lists shared powers and does not assert activist or control intent in the provided excerpt.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Accepted by SEC EDGAR 05/12/2026 - 09:51 AM Learn about SEC filing dates

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

APELLIS PHARMACEUTICALS INC

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

03753U106

(CUSIP Number)

03/31/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 03753U106

1

Names of Reporting Persons

STATE STREET CORPORATION

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

MASSACHUSETTS

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 6,603,712.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 6,845,031.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

6,845,031.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.4 %

12

Type of Reporting Person (See Instructions)

HC

SCHEDULE 13G

Item 1.
(a)	Name of issuer: APELLIS PHARMACEUTICALS INC
(b)	Address of issuer's principal executive offices: 100 5TH AVENUE, WALTHAM, MASSACHUSETTS, 02451
Item 2.
(a)	Name of person filing: STATE STREET CORPORATION;
(b)	Address or principal business office or, if none, residence: ONE CONGRESS STREET, SUITE 1, BOSTON MA 02114, UNITED STATES
(c)	Citizenship: MA
(d)	Title of class of securities: COMMON STOCK
(e)	CUSIP Number(s): 03753U106
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 6845031.00
(b)	Percent of class: 5.4 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 0
	(ii) Shared power to vote or to direct the vote: 6,603,712
	(iii) Sole power to dispose or to direct the disposition of: 0
	(iv) Shared power to dispose or to direct the disposition of: 6,845,031
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. NOT APPLICABLE
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. SSGA FUNDS MANAGEMENT, INC. (IA);STATE STREET BANK AND TRUST COMPANY (BK);STATE STREET GLOBAL ADVISORS EUROPE LIMITED (IA);STATE STREET GLOBAL ADVISORS LIMITED (IA);STATE STREET GLOBAL ADVISORS TRUST COMPANY (IA);STATE STREET GLOBAL ADVISORS, LTD. (IA);
Item 8.	Identification and Classification of Members of the Group.
	If a group has filed this schedule pursuant to §240.13d-1(b)(1)(ii)(K), so indicate under Item 3(k) and attach an exhibit stating the identity and Item 3 classification of each member of the group. If a group has filed this schedule pursuant to §240.13d-1(c) or §240.13d-1(d), attach an exhibit stating the identity of each member of the group. NOT APPLICABLE
Item 9.	Notice of Dissolution of Group.
	Notice of dissolution of a group may be furnished as an exhibit stating the date of the dissolution and that all further filings with respect to transactions in the security reported on will be filed, if required, by members of the group, in their individual capacity. See Item 5. NOT APPLICABLE

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

STATE STREET CORPORATION

Signature:	ELIZABETH SCHAEFER
Name/Title:	SENIOR VICE PRESIDENT, CHIEF ACCOUNTING OFFICER
Date:	05/12/2026